Q0ZM35 (Q0ZM35_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protocadherin-15-CD1 isoform 4 EMBL ABC79261.1

Gene names

Name:

Pcdh15 MGI 1891428

Organism

Mus musculus (Mouse) EMBL ABC79261.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1936 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS020894
Cellular component	Membrane
Domain	Repeat SAAS SAAS020894 Transmembrane SAAS SAAS020894
Ligand	Calcium RuleBase RU000484 SAAS SAAS020894
Gene Ontology (GO)
Biological_process	actin filament organization Inferred from mutant phenotype PubMed 11124469. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 11124469. Source: MGI auditory receptor cell stereocilium organization Inferred from mutant phenotype PubMed 10978835PubMed 11124469PubMed 16887306. Source: MGI detection of mechanical stimulus involved in equilibrioception Inferred from mutant phenotype PubMed 16481439. Source: MGI detection of mechanical stimulus involved in sensory perception of sound Inferred from mutant phenotype PubMed 16481439. Source: MGI homophilic cell adhesion Inferred from electronic annotation. Source: InterPro morphogenesis of an epithelium Inferred from mutant phenotype PubMed 11138007. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 10978835. Source: MGI nonmotile primary cilium assembly Inferred from mutant phenotype PubMed 16481439. Source: MGI righting reflex Inferred from mutant phenotype PubMed 10978835PubMed 15811708. Source: MGI startle response Inferred from mutant phenotype PubMed 15811708. Source: MGI visual perception Inferred from mutant phenotype PubMed 16799054. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 16481439. Source: MGI integral to membrane Inferred from sequence or structural similarity PubMed 11138007. Source: MGI photoreceptor outer segment Inferred from direct assay PubMed 14570705. Source: MGI plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0ZM35 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 62B5BCE5FA8C07FD	FASTA	1,936	213,827
	10 20 30 40 50 60 MFLQFAVWKC LPHGILIASL LVVSWGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM 70 80 90 100 110 120 LIKGTAGGPD PTIELSLKDN VDYWVLLDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC 130 140 150 160 170 180 VNKKVGTVIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID 190 200 210 220 230 240 DGPNGQIEYV IQYNPEDPTS NDTFEIPLML TGNVVLRKRL NYEDKTRYYV IIQANDRAQN 250 260 270 280 290 300 LNERRTTTTT LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPILV 310 320 330 340 350 360 TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELTLL EPVNRDFHQK 370 380 390 400 410 420 FDLVIKAEQD NGHPLPAFAS LHIEILDENN QSPYFTMPSY QGYILESAPV GATISESLNL 430 440 450 460 470 480 TTPLRIVALD KDIEDTKDPE LHLFLNDYTS VFTVTPTGIT RYLTLLQPVD REEQQTYTFL 490 500 510 520 530 540 ITAFDGVQES EPVVVNIRVM DANDNTPTFP EISYDVYVYT DMSPGDSVIQ LTAVDADEGS 550 560 570 580 590 600 NGEISYEILV GGKGDFVINK TTGLVSIAPG VELIVGQTYA LTVQASDNAP PAERRHSICT 610 620 630 640 650 660 VYTEVLPPNN QSPPRFPQLM YSLEVSEAMR IGAILLNLQA TDREGDPITY AIENGDPQRV 670 680 690 700 710 720 FNLSETTGIL SLGKALDRES TDRYILIVTA SDGRPDGTST ATVNIVVTDV NDNAPVFDPY 730 740 750 760 770 780 LPRNLSVVEE EANAFVGQVR ATDPDAGING QVHYSLGNFN NLFRITSNGS IYTAVKLNRE 790 800 810 820 830 840 ARDHYELVVV ATDGAVHPRH STLTLYIKVL DIDDNSPVFT NSTYTVVVEE NLPAGTSFLQ 850 860 870 880 890 900 IEAKDVDLGA NVSYRIRSPE VKHLFALHPF TGELSLLRSL DYEAFPDQEA SITFLAEAFD 910 920 930 940 950 960 IYGTMPPGIA TVTVIVKDMN DYPPVFSKRI YKGMVAPDAV KGTPITTVYA EDADPPGMPA 970 980 990 1000 1010 1020 SRVRYRVDDV QFPYPASIFD VEEDSGRVVT RVNLNEEPTT IFKLVVVAFD DGEPVMSSSA 1030 1040 1050 1060 1070 1080 TVRILVLHPG EIPRFTQEEY RPPPVSELAA RGTVVGVISA AAINQSIVYS IVAGNEEDKF 1090 1100 1110 1120 1130 1140 GINNVTGVIY VNSPLDYETR TSYVLRVQAD SLEVVLANLR VPSKSNTAKV YIEIQDENDH 1150 1160 1170 1180 1190 1200 PPVFQKKFYI GGVSEDARMF ASVLRVKATD RDTGNYSAMA YRLIIPPIKE GKEGFVVETY 1210 1220 1230 1240 1250 1260 TGLIKTAMLF HNMRRSYFKF QVIATDDYGK GLSGKADVLV SVVNQLDMQV IVSNVPPTLV 1270 1280 1290 1300 1310 1320 EKKIEDLTEI LDRYVQEQIP GAKVVVESIG ARRHGDAYSL EDYSKCDLTV YAIDPQTNRA 1330 1340 1350 1360 1370 1380 IDRNELFKFL DGKLLDINKD FQPYYGEGGR ILEIRTPEAV TSIKKRGESL GYTEGALLAL 1390 1400 1410 1420 1430 1440 AFIIILCCIP AILVVLVSYR QFKVRQAECT KTARIQSAMP AAKPAAPVPA APAPPPPPPP 1450 1460 1470 1480 1490 1500 PPPGAHLYEE LGESAILFLL YHFEQSRGNN SVPEDRSSHR DGMAFSSSTT ESHEPAHVEG 1510 1520 1530 1540 1550 1560 PLKESQPNPA RTFSFVPDED NLSTHNPLYM ESIGQRSTNS DLQPRTDFEE LLAPRTQVKS 1570 1580 1590 1600 1610 1620 QSLRGPREKI QRVWNQSVSF PRRLMWKAPN RPETIDLVEW QITNQRAECE SARCHPSQRG 1630 1640 1650 1660 1670 1680 SSNVLLATED AHESEKEGGH RDTLIVQQTE QLKSLSSGSS FSSSWSHFSF STLPTISRAV 1690 1700 1710 1720 1730 1740 ELGSEPNVVT SPADCTLELS PPLRPRILNS LSSKRETPTC ASDTEPKRNS FEIAPHPPSI 1750 1760 1770 1780 1790 1800 FAPLPHPPLP RPPIAFTTFP LPLSPPNPPP PQLVTFSLPI STPPTSSLPL PPPLSLPPPP 1810 1820 1830 1840 1850 1860 RPPAPRLFPQ PPSTSIPSTD SISAPAAKCT ASATHARETT FTTQPPASNP QWGAEPHRHP 1870 1880 1890 1900 1910 1920 KGILRHVKNL AELEKSVSNM YSHIEKNCPP ADPSKLHTFC PAEKTGMKIT HDQSQETLVR 1930 VVEGIDVQPH SQSTSL

References

[1]

"The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15." Ahmed Z.M., Goodyear R., Riazuddin S., Lagziel A., Legan P.K., Behra M., Burgess S.M., Lilley K.S., Wilcox E.R., Riazuddin S., Griffith A.J., Frolenkov G.I., Belyantseva I.A., Richardson G.P., Friedman T.B. J. Neurosci. 26:7022-7034(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL ABC79261.1. Tissue: Inner ear EMBL ABC79261.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ354398 mRNA. Translation: ABC79261.1.
IPI	IPI00121093.
RefSeq	NP_001136208.1. NM_001142736.1.
UniGene	Mm.338933. Mm.490709.
3D structure databases
ProteinModelPortal	Q0ZM35.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0ZM35.
Proteomic databases
PRIDE	Q0ZM35.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	11994.
KEGG	mmu:11994.
UCSC	uc007fpl.2. mouse.
Organism-specific databases
CTD	65217.
MGI	MGI:1891428. Pcdh15.
Phylogenomic databases
HOGENOM	HOG000230919.
HOVERGEN	HBG053521.
KO	K16500.
Gene expression databases
ArrayExpress	Q0ZM35.
Genevestigator	Q0ZM35.
Family and domain databases
Gene3D	2.60.40.60. 10 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 8 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 11 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 10 hits.
PROSITE	PS00232. CADHERIN_1. 4 hits. PS50268. CADHERIN_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	280177.
SOURCE	Search...

Entry information

Entry name

Q0ZM35_MOUSE

Accession

Primary (citable) accession number: Q0ZM35

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)