Q0ZM31 (Q0ZM31_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protocadherin-15-CD1 isoform 9 EMBL ABC79265.1

Gene names

Name:

Pcdh15 MGI 1891428

Organism

Mus musculus (Mouse) EMBL ABC79265.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1916 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS015919
Cellular component	Membrane
Domain	Repeat SAAS SAAS015919 Transmembrane SAAS SAAS002126
Ligand	Calcium SAAS SAAS015919 RuleBase RU000484
Gene Ontology (GO)
Biological_process	actin filament organization Inferred from mutant phenotype PubMed 11124469. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 11124469. Source: MGI auditory receptor cell stereocilium organization Inferred from mutant phenotype PubMed 10978835PubMed 11124469PubMed 16887306PubMed 23217710. Source: MGI detection of mechanical stimulus involved in equilibrioception Inferred from mutant phenotype PubMed 16481439. Source: MGI detection of mechanical stimulus involved in sensory perception of sound Inferred from mutant phenotype PubMed 16481439. Source: MGI homophilic cell adhesion Inferred from electronic annotation. Source: InterPro morphogenesis of an epithelium Inferred from mutant phenotype PubMed 11138007. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 10978835. Source: MGI nonmotile primary cilium assembly Inferred from mutant phenotype PubMed 16481439. Source: MGI righting reflex Inferred from mutant phenotype PubMed 10978835PubMed 15811708. Source: MGI startle response Inferred from mutant phenotype PubMed 15811708. Source: MGI visual perception Inferred from mutant phenotype PubMed 16799054. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 16481439. Source: MGI integral to membrane Inferred from sequence or structural similarity PubMed 11138007. Source: MGI photoreceptor outer segment Inferred from direct assay PubMed 14570705. Source: MGI plasma membrane Inferred from direct assay PubMed 23217710. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0ZM31 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 28173961358875CF	FASTA	1,916	211,801
	10 20 30 40 50 60 MFLQFAVWKC LPHGILIASL LVVSWGQYDD GTILVDNMLI KGTAGGPDPT IELSLKDNVD 70 80 90 100 110 120 YWVLLDPVKQ MLFLNSTGRV LDRDPPMNIH SIVVQVQCVN KKVGTVIYHE VRIVVRDRND 130 140 150 160 170 180 NSPTFKHESY YATVNELTPV GTTIFTGFSG DNGATDIDDG PNGQIEYVIQ YNPEDPTSND 190 200 210 220 230 240 TFEIPLMLTG NVVLRKRLNY EDKTRYYVII QANDRAQNLN ERRTTTTTLT VDVLDGDDLG 250 260 270 280 290 300 PMFLPCVLVP NTRDCRPLTY QAAIPELRTP EELNPILVTP PIQAIDQDRN IQPPSDRPGI 310 320 330 340 350 360 LYSILVGTPE DYPRFFHMHP RTAELTLLEP VNRDFHQKFD LVIKAEQDNG HPLPAFASLH 370 380 390 400 410 420 IEILDENNQS PYFTMPSYQG YILESAPVGA TISESLNLTT PLRIVALDKD IEDTKDPELH 430 440 450 460 470 480 LFLNDYTSVF TVTPTGITRY LTLLQPVDRE EQQTYTFLIT AFDGVQESEP VVVNIRVMDA 490 500 510 520 530 540 NDNTPTFPEI SYDVYVYTDM SPGDSVIQLT AVDADEGSNG EISYEILVGG KGDFVINKTT 550 560 570 580 590 600 GLVSIAPGVE LIVGQTYALT VQASDNAPPA ERRHSICTVY TEVLPPNNQS PPRFPQLMYS 610 620 630 640 650 660 LEVSEAMRIG AILLNLQATD REGDPITYAI ENGDPQRVFN LSETTGILSL GKALDRESTD 670 680 690 700 710 720 RYILIVTASD GRPDGTSTAT VNIVVTDVND NAPVFDPYLP RNLSVVEEEA NAFVGQVRAT 730 740 750 760 770 780 DPDAGINGQV HYSLGNFNNL FRITSNGSIY TAVKLNREAR DHYELVVVAT DGAVHPRHST 790 800 810 820 830 840 LTLYIKVLDI DDNSPVFTNS TYTVVVEENL PAGTSFLQIE AKDVDLGANV SYRIRSPEVK 850 860 870 880 890 900 HLFALHPFTG ELSLLRSLDY EAFPDQEASI TFLAEAFDIY GTMPPGIATV TVIVKDMNDY 910 920 930 940 950 960 PPVFSKRIYK GMVAPDAVKG TPITTVYAED ADPPGMPASR VRYRVDDVQF PYPASIFDVE 970 980 990 1000 1010 1020 EDSGRVVTRV NLNEEPTTIF KLVVVAFDDG EPVMSSSATV RILVLHPGEI PRFTQEEYRP 1030 1040 1050 1060 1070 1080 PPVSELAARG TVVGVISAAA INQSIVYSIV AGNEEDKFGI NNVTGVIYVN SPLDYETRTS 1090 1100 1110 1120 1130 1140 YVLRVQADSL EVVLANLRVP SKSNTAKVYI EIQDENDHPP VFQKKFYIGG VSEDARMFAS 1150 1160 1170 1180 1190 1200 VLRVKATDRD TGNYSAMAYR LIIPPIKEGK EGFVVETYTG LIKTAMLFHN MRRSYFKFQV 1210 1220 1230 1240 1250 1260 IATDDYGKGL SGKADVLVSV VNQLDMQVIV SNVPPTLVEK KIEDLTEILD RYVQEQIPGA 1270 1280 1290 1300 1310 1320 KVVVESIGAR RHGDAYSLED YSKCDLTVYA IDPQTNRAID RNELFKFLDG KLLDINKDFQ 1330 1340 1350 1360 1370 1380 PYYGEGGRIL EIRTPEAVTS IKKRGESLGY TEGALLALAF IIILCCIPAI LVVLVSYRQF 1390 1400 1410 1420 1430 1440 KVRQAECTKT ARIQSAMPAA KPAAPVPAAP APPPPPPPPP PGAHLYEELG ESAMHNLFLL 1450 1460 1470 1480 1490 1500 YHFEQSRGNN SVPEDRSSHR DGMAFSSSTT ESHEPAHVEG PLKESQPNPA RTFSFVPDED 1510 1520 1530 1540 1550 1560 NLSTHNPLYM ESIGQRSTNS DLQPRTDFEE LLAPRTQVKS QSLRGPREKI QRVWNQSVSF 1570 1580 1590 1600 1610 1620 PRRLMWKAPN RPETIDLVEW QITNQRAECE SARCHPSQRG SSNVLLATED AHESEKEGGH 1630 1640 1650 1660 1670 1680 RDTLIVQQTE QLKSLSSGSS FSSSWSHFSF STLPTISRAV ELGSEPNVVT SPADCTLELS 1690 1700 1710 1720 1730 1740 PPLRPRILNS LSSKRETPTC ASDTEPKRNS FEIAPHPPSI FAPLPHPPLP RPPIAFTTFP 1750 1760 1770 1780 1790 1800 LPLSPPNPPP PQLVTFSLPI STPPTSSLPL PPPLSLPPPP RPPAPRLFPQ PPSTSIPSTD 1810 1820 1830 1840 1850 1860 SISAPAAKCT ASATHARETT FTTQPPASNP QWGAEPHRHP KGILRHVKNL AELEKSVSNM 1870 1880 1890 1900 1910 YSHIEKNCPP ADPSKLHTFC PAEKTGMKIT HDQSQETLVR VVEGIDVQPH SQSTSL

References

[1]

"The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15." Ahmed Z.M., Goodyear R., Riazuddin S., Lagziel A., Legan P.K., Behra M., Burgess S.M., Lilley K.S., Wilcox E.R., Riazuddin S., Griffith A.J., Frolenkov G.I., Belyantseva I.A., Richardson G.P., Friedman T.B. J. Neurosci. 26:7022-7034(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL ABC79265.1. Tissue: Inner ear EMBL ABC79265.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ354402 mRNA. Translation: ABC79265.1.
IPI	IPI00121093.
RefSeq	NP_001136211.1. NM_001142739.1.
UniGene	Mm.338933. Mm.490709.
3D structure databases
ProteinModelPortal	Q0ZM31.
ModBase	Search...
Proteomic databases
PRIDE	Q0ZM31.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	11994.
KEGG	mmu:11994.
Organism-specific databases
CTD	65217.
MGI	MGI:1891428. Pcdh15.
Phylogenomic databases
HOVERGEN	HBG053521.
InParanoid	Q0ZM31.
KO	K16500.
Gene expression databases
ArrayExpress	Q0ZM31.
Genevestigator	Q0ZM31.
Family and domain databases
Gene3D	2.60.40.60. 10 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 8 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 11 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 10 hits.
PROSITE	PS00232. CADHERIN_1. 4 hits. PS50268. CADHERIN_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	280177.
SOURCE	Search...

Entry information

Entry name

Q0ZM31_MOUSE

Accession

Primary (citable) accession number: Q0ZM31

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	May 29, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)