Q0ZM20 (Q0ZM20_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protocadherin-15-CD3 isoform 1 EMBL ABC79276.1

Gene names

Name:

Pcdh15 MGI 1891428

Organism

Mus musculus (Mouse) EMBL ABC79276.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1682 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS020894
Cellular component	Membrane
Domain	Repeat SAAS SAAS020894 Transmembrane SAAS SAAS020894
Ligand	Calcium RuleBase RU000484 SAAS SAAS020894
Gene Ontology (GO)
Biological_process	actin filament organization Inferred from mutant phenotype PubMed 11124469. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 11124469. Source: MGI auditory receptor cell stereocilium organization Inferred from mutant phenotype PubMed 10978835PubMed 11124469PubMed 16887306. Source: MGI detection of mechanical stimulus involved in equilibrioception Inferred from mutant phenotype PubMed 16481439. Source: MGI detection of mechanical stimulus involved in sensory perception of sound Inferred from mutant phenotype PubMed 16481439. Source: MGI homophilic cell adhesion Inferred from electronic annotation. Source: InterPro morphogenesis of an epithelium Inferred from mutant phenotype PubMed 11138007. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 10978835. Source: MGI nonmotile primary cilium assembly Inferred from mutant phenotype PubMed 16481439. Source: MGI righting reflex Inferred from mutant phenotype PubMed 10978835PubMed 15811708. Source: MGI startle response Inferred from mutant phenotype PubMed 15811708. Source: MGI visual perception Inferred from mutant phenotype PubMed 16799054. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 16481439. Source: MGI integral to membrane Inferred from sequence or structural similarity PubMed 11138007. Source: MGI photoreceptor outer segment Inferred from direct assay PubMed 14570705. Source: MGI plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0ZM20 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 74FCB872A6D1CB57	FASTA	1,682	186,501
	10 20 30 40 50 60 MFLQFAVWKC LPHGILIASL LVVSWGQYDD DWQYEDCKLA RGGPPATIVA IDEESRNGTI 70 80 90 100 110 120 LVDNMLIKGT AGGPDPTIEL SLKDNVDYWV LLDPVKQMLF LNSTGRVLDR DPPMNIHSIV 130 140 150 160 170 180 VQVQCVNKKV GTVIYHEVRI VVRDRNDNSP TFKHESYYAT VNELTPVGTT IFTGFSGDNG 190 200 210 220 230 240 ATDIDDGPNG QIEYVIQYNP EDPTSNDTFE IPLMLTGNVV LRKRLNYEDK TRYYVIIQAN 250 260 270 280 290 300 DRAQNLNERR TTTTTLTVDV LDGDDLGPMF LPCVLVPNTR DCRPLTYQAA IPELRTPEEL 310 320 330 340 350 360 NPILVTPPIQ AIDQDRNIQP PSDRPGILYS ILVGTPEDYP RFFHMHPRTA ELTLLEPVNR 370 380 390 400 410 420 DFHQKFDLVI KAEQDNGHPL PAFASLHIEI LDENNQSPYF TMPSYQGYIL ESAPVGATIS 430 440 450 460 470 480 ESLNLTTPLR IVALDKDIED TKDPELHLFL NDYTSVFTVT PTGITRYLTL LQPVDREEQQ 490 500 510 520 530 540 TYTFLITAFD GVQESEPVVV NIRVMDANDN TPTFPEISYD VYVYTDMSPG DSVIQLTAVD 550 560 570 580 590 600 ADEGSNGEIS YEILVGGKGD FVINKTTGLV SIAPGVELIV GQTYALTVQA SDNAPPAERR 610 620 630 640 650 660 HSICTVYTEV LPPNNQSPPR FPQLMYSLEV SEAMRIGAIL LNLQATDREG DPITYAIENG 670 680 690 700 710 720 DPQRVFNLSE TTGILSLGKA LDRESTDRYI LIVTASDGRP DGTSTATVNI VVTDVNDNAP 730 740 750 760 770 780 VFDPYLPRNL SVVEEEANAF VGQVRATDPD AGINGQVHYS LGNFNNLFRI TSNGSIYTAV 790 800 810 820 830 840 KLNREARDHY ELVVVATDGA VHPRHSTLTL YIKVLDIDDN SPVFTNSTYT VVVEENLPAG 850 860 870 880 890 900 TSFLQIEAKD VDLGANVSYR IRSPEVKHLF ALHPFTGELS LLRSLDYEAF PDQEASITFL 910 920 930 940 950 960 AEAFDIYGTM PPGIATVTVI VKDMNDYPPV FSKRIYKGMV APDAVKGTPI TTVYAEDADP 970 980 990 1000 1010 1020 PGMPASRVRY RVDDVQFPYP ASIFDVEEDS GRVVTRVNLN EEPTTIFKLV VVAFDDGEPV 1030 1040 1050 1060 1070 1080 MSSSATVRIL VLHPGEIPRF TQEEYRPPPV SELAARGTVV GVISAAAINQ SIVYSIVAGN 1090 1100 1110 1120 1130 1140 EEDKFGINNV TGVIYVNSPL DYETRTSYVL RVQADSLEVV LANLRVPSKS NTAKVYIEIQ 1150 1160 1170 1180 1190 1200 DENDHPPVFQ KKFYIGGVSE DARMFASVLR VKATDRDTGN YSAMAYRLII PPIKEGKEGF 1210 1220 1230 1240 1250 1260 VVETYTGLIK TAMLFHNMRR SYFKFQVIAT DDYGKGLSGK ADVLVSVVNQ LDMQVIVSNV 1270 1280 1290 1300 1310 1320 PPTLVEKKIE DLTEILDRYV QEQIPGAKVV VESIGARRHG DAYSLEDYSK CDLTVYAIDP 1330 1340 1350 1360 1370 1380 QTNRAIDRNE LFKFLDGKLL DINKDFQPYY GEGGRILEIR TPEAVTSIKK RGESLGYTEG 1390 1400 1410 1420 1430 1440 ALLALAFIII LCCIPAILVV LVSYRQFKVR QAECTKTARI QSAMPAAKPA APVPAAPAPP 1450 1460 1470 1480 1490 1500 PPPPPPPPGA HLYEELGESA MHKYEMPQYG SRRRLLPPAG QEEYGEVIGE AEEEYEEEEW 1510 1520 1530 1540 1550 1560 ARKRMIKLVV DREYESSSPG EDSAPESQRS RTHKPSGRSN VNGNIYIAQN GSVVRTRRAC 1570 1580 1590 1600 1610 1620 VADNLKVPSP GLLGRHLKKL DTLAGTREEN VPLNTLFKGP FSTEKAKRTP TLVTFAPCPV 1630 1640 1650 1660 1670 1680 VAEHSAVKPS GTRLKHTAEQ ESMVDSRLSR ESMEFHGDSA PSDEEELWMG PWNSLHIPMT KL

References

[1]	"The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15." Ahmed Z.M., Goodyear R., Riazuddin S., Lagziel A., Legan P.K., Behra M., Burgess S.M., Lilley K.S., Wilcox E.R., Riazuddin S., Griffith A.J., Frolenkov G.I., Belyantseva I.A., Richardson G.P., Friedman T.B. J. Neurosci. 26:7022-7034(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL ABC79276.1. Tissue: Inner ear EMBL ABC79276.1.
[2]	Ahmed Z. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL ABC79276.1. Tissue: Inner ear EMBL ABC79276.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ354413 mRNA. Translation: ABC79276.1.
IPI	IPI00606668.
RefSeq	NP_001136218.1. NM_001142746.1.
UniGene	Mm.338933. Mm.490709.
3D structure databases
ProteinModelPortal	Q0ZM20.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0ZM20.
Proteomic databases
PRIDE	Q0ZM20.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	11994.
KEGG	mmu:11994.
UCSC	uc011xgg.1. mouse.
Organism-specific databases
CTD	65217.
MGI	MGI:1891428. Pcdh15.
Phylogenomic databases
HOGENOM	HOG000230919.
HOVERGEN	HBG053521.
KO	K16500.
Gene expression databases
ArrayExpress	Q0ZM20.
Genevestigator	Q0ZM20.
Family and domain databases
Gene3D	2.60.40.60. 10 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 8 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 11 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 10 hits.
PROSITE	PS00232. CADHERIN_1. 4 hits. PS50268. CADHERIN_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	280177.
SOURCE	Search...

Entry information

Entry name

Q0ZM20_MOUSE

Accession

Primary (citable) accession number: Q0ZM20

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	March 6, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)