Q0ZM16 (Q0ZM16_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protocadherin-15 Ensembl ENSMUSP00000120056

Submitted name:
Protocadherin-15-secreted isoform 2 EMBL ABC79280.1

Gene names

Name:

Pcdh15 MGI 1891428 Ensembl ENSMUSP00000120056

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1171 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS020894
Cellular component	Membrane
Domain	Repeat SAAS SAAS020894 Transmembrane SAAS SAAS020894
Ligand	Calcium SAAS SAAS020894 RuleBase RU000484
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament organization Inferred from mutant phenotype PubMed 11124469. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 11124469. Source: MGI auditory receptor cell stereocilium organization Inferred from mutant phenotype PubMed 10978835PubMed 11124469PubMed 16887306. Source: MGI detection of mechanical stimulus involved in equilibrioception Inferred from mutant phenotype PubMed 16481439. Source: MGI detection of mechanical stimulus involved in sensory perception of sound Inferred from mutant phenotype PubMed 16481439. Source: MGI homophilic cell adhesion Inferred from electronic annotation. Source: InterPro morphogenesis of an epithelium Inferred from mutant phenotype PubMed 11138007. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 10978835. Source: MGI nonmotile primary cilium assembly Inferred from mutant phenotype PubMed 16481439. Source: MGI righting reflex Inferred from mutant phenotype PubMed 10978835PubMed 15811708. Source: MGI startle response Inferred from mutant phenotype PubMed 15811708. Source: MGI visual perception Inferred from mutant phenotype PubMed 16799054. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 16481439. Source: MGI integral to membrane Inferred from sequence or structural similarity PubMed 11138007. Source: MGI photoreceptor outer segment Inferred from direct assay PubMed 14570705. Source: MGI plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0ZM16 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: F1F9A2CAA115DEA2	FASTA	1,171	129,132
	10 20 30 40 50 60 MFLQFAVWKC LPHGILIASL LVVSWGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM 70 80 90 100 110 120 LIKGTAGGPD PTIELSLKDN VDYWVLLDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC 130 140 150 160 170 180 VNKKVGTVIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID 190 200 210 220 230 240 DGPNGQIEYV IQYNPEDPTS NDTFEIPLML TGNVVLRKRL NYEDKTRYYV IIQANDRAQN 250 260 270 280 290 300 LNERRTTTTT LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPILV 310 320 330 340 350 360 TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELTLL EPVNRDFHQK 370 380 390 400 410 420 FDLVIKAEQD NGHPLPAFAS LHIEILDENN QSPYFTMPSY QGYILESAPV GATISESLNL 430 440 450 460 470 480 TTPLRIVALD KDIEDTKDPE LHLFLNDYTS VFTVTPTGIT RYLTLLQPVD REEQQTYTFL 490 500 510 520 530 540 ITAFDGVQES EPVVVNIRVM DANDNTPTFP EISYDVYVYT DMSPGDSVIQ LTAVDADEGS 550 560 570 580 590 600 NGEISYEILV GGKGDFVINK TTGLVSIAPG VELIVGQTYA LTVQASDNAP PAERRHSICT 610 620 630 640 650 660 VYIEVLPPNN QSPPRFPQLM YSLEVSEAMR IGAILLNLQA TDREGDPITY AIENGDPQRV 670 680 690 700 710 720 FNLSETTGIL SLGKALDRES TDRYILIVTA SDGRPDGTST ATVNIVVTDV NDNAPVFDPY 730 740 750 760 770 780 LPRNLSVVEE EANAFVGQVR ATDPDAGING QVHYSLGNFN NLFRITSNGS IYTAVKLNRE 790 800 810 820 830 840 ARDHYELVVV ATDGAVHPRH STLTLYIKVL DIDDNSPVFT NSTYTVVVEE NLPAGTSFLQ 850 860 870 880 890 900 IEAKDVDLGA NVSYRIRSPE VKHLFALHPF TGELSLLRSL DYEAFPDQEA SITFLVEAFD 910 920 930 940 950 960 IYGTMPPGIA TVTVIVKDMN DYPPVFSKRI YKGMVAPDAV KGTPITTVYA EDADPPGMPA 970 980 990 1000 1010 1020 SRVRYRVDDV QFPYPASIFD VEEDSGRVVT RVNLNEEPTT IFKLVVVAFD DGEPVMSSSA 1030 1040 1050 1060 1070 1080 TVRILVLHPG EIPRFTQEEY RPPPVSELAA RGTVVGVISA AAINQSIVYS IVAGNEEDKF 1090 1100 1110 1120 1130 1140 GINNVTGVIY VNSPLDYETR TSYVLRVQAD SLEVVLANLR VPSKSLSVIP CSWRTQVSKS 1150 1160 1170 LGLELGVPVS HSVESGTRTG SSTRAASVPI H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15." Ahmed Z.M., Goodyear R., Riazuddin S., Lagziel A., Legan P.K., Behra M., Burgess S.M., Lilley K.S., Wilcox E.R., Riazuddin S., Griffith A.J., Frolenkov G.I., Belyantseva I.A., Richardson G.P., Friedman T.B. J. Neurosci. 26:7022-7034(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL ABC79280.1. Tissue: Inner ear EMBL ABC79280.1.
[2]	Ahmed Z. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL ABC79280.1. Tissue: Inner ear EMBL ABC79280.1.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000120056.
[4]	Ensembl Submitted (JUN-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000120056.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC108392 Genomic DNA. No translation available. AC119894 Genomic DNA. No translation available. AC121142 Genomic DNA. No translation available. AC121602 Genomic DNA. No translation available. AC121832 Genomic DNA. No translation available. AC123032 Genomic DNA. No translation available. AC123809 Genomic DNA. No translation available. AC144802 Genomic DNA. No translation available. AC147721 Genomic DNA. No translation available. AC153858 Genomic DNA. No translation available. AC158800 Genomic DNA. No translation available. AC159477 Genomic DNA. No translation available. AC186813 Genomic DNA. No translation available. AC188091 Genomic DNA. No translation available. CAAA01110489 Genomic DNA. No translation available. DQ354417 mRNA. Translation: ABC79280.1.
IPI	IPI00830651.
RefSeq	NP_001136220.1. NM_001142748.1.
UniGene	Mm.338933. Mm.490709.
3D structure databases
SMR	Q0ZM16. Positions 27-1125.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000125006; ENSMUSP00000120056; ENSMUSG00000052613.
GeneID	11994.
KEGG	mmu:11994.
UCSC	uc007fpg.2. mouse.
Organism-specific databases
CTD	65217.
MGI	MGI:1891428. Pcdh15.
Phylogenomic databases
GeneTree	ENSGT00700000104156.
HOVERGEN	HBG053521.
KO	K16500.
Gene expression databases
Genevestigator	Q0ZM16.
Family and domain databases
Gene3D	2.60.40.60. 9 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 8 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 10 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 9 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	280177.
SOURCE	Search...

Entry information

Entry name

Q0ZM16_MOUSE

Accession

Primary (citable) accession number: Q0ZM16
Secondary accession number(s): F6XPA1

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)