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Protein

Atlastin-3

Gene

Atl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 74GTPBy similarity8
Nucleotide bindingi114 – 116GTPBy similarity3
Nucleotide bindingi213 – 214GTPBy similarity2
Nucleotide bindingi272 – 275GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Atlastin-3 (EC:3.6.5.-)
Gene namesi
Name:Atl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309871. Atl3.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. Localizes to endoplasmic reticulum tubular network.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 445CytoplasmicBy similarityAdd BLAST445
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467LumenalSequence analysis1
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Topological domaini489 – 541CytoplasmicBy similarityAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871111 – 541Atlastin-3Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei391N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ0ZHH6.
PRIDEiQ0ZHH6.

PTM databases

iPTMnetiQ0ZHH6.
PhosphoSitePlusiQ0ZHH6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021203.

Interactioni

Subunit structurei

Interacts with ZFYVE27.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063444.

Structurei

3D structure databases

ProteinModelPortaliQ0ZHH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 306GB1/RHD3-type GAdd BLAST250

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ0ZHH6.
KOiK17339.
PhylomeDBiQ0ZHH6.
TreeFamiTF105251.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0ZHH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPQRTAAV ASRGAGDAME NGKPGPVQVV LVHKEQHSFE LEERALASVL
60 70 80 90 100
LQDHIRDLDV VVVSVAGAFR KGKSFILDFM LRYLYSQKEH GHSNWLGDPE
110 120 130 140 150
EPLTGFSWRG GSDPETTGIQ IWSEVFTVKK PCGKEVAVVL MDTQGAFDSQ
160 170 180 190 200
STVKDCATIF ALSTMTSSVQ IYNLSQNIQE DDLQQLQLFT EYGRLAMDEI
210 220 230 240 250
FQKPFQTLMF LVRDWSFPYE YNYGLQGGMS FLDKRLQVKE HQHEEIQNVR
260 270 280 290 300
NHIHSCFSDV TCFLLPHPGL QVATSPDFDG KLKEYIASEF KEQLQTLIPY
310 320 330 340 350
VLNPSKLMEK EINGSKVTCR GLLEYFKAYI KIYQGEDLPH PKSMLQATAA
360 370 380 390 400
NNLAAAASAK DIYYSSMEEI CGGEKPYLSP DILEEKHQEF KQLALDHFKK
410 420 430 440 450
TKKMGGKDFS FRYQQELEEE ITELYENFCK HNGSKNVFST FRTPAVLFTG
460 470 480 490 500
IAVLYIASGL TGFIGLEVVA QLFNCMVGLL LIALLTWGYI RYSGQYLELG
510 520 530 540
GAIDSGAAYV LEQASSHIGN STQAAVRDAI AGRPPADKKS Q
Length:541
Mass (Da):60,586
Last modified:May 15, 2007 - v2
Checksum:iF74C6CED80221EAF
GO
Isoform 2 (identifier: Q0ZHH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MLSPQRTAAVASRGA → MDPRFQYAVT

Show »
Length:536
Mass (Da):60,298
Checksum:iEE05AA8CC91ECDD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284 – 285EY → D in ABE26990 (PubMed:14506257).Curated2
Sequence conflicti349A → AE in ABE26990 (PubMed:14506257).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253151 – 15MLSPQ…ASRGA → MDPRFQYAVT in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ450893 mRNA. Translation: ABE26990.1.
AABR03000230 Genomic DNA. No translation available.
RefSeqiNP_001037706.1. NM_001044241.1.
UniGeneiRn.202359.

Genome annotation databases

GeneIDi309187.
KEGGirno:309187.
UCSCiRGD:1309871. rat. [Q0ZHH6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ450893 mRNA. Translation: ABE26990.1.
AABR03000230 Genomic DNA. No translation available.
RefSeqiNP_001037706.1. NM_001044241.1.
UniGeneiRn.202359.

3D structure databases

ProteinModelPortaliQ0ZHH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063444.

PTM databases

iPTMnetiQ0ZHH6.
PhosphoSitePlusiQ0ZHH6.

Proteomic databases

PaxDbiQ0ZHH6.
PRIDEiQ0ZHH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309187.
KEGGirno:309187.
UCSCiRGD:1309871. rat. [Q0ZHH6-1]

Organism-specific databases

CTDi25923.
RGDi1309871. Atl3.

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ0ZHH6.
KOiK17339.
PhylomeDBiQ0ZHH6.
TreeFamiTF105251.

Miscellaneous databases

PROiQ0ZHH6.

Gene expression databases

BgeeiENSRNOG00000021203.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATLA3_RAT
AccessioniPrimary (citable) accession number: Q0ZHH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.