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Protein

Peroxisome proliferator-activated receptor delta

Gene

PPARD

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 145Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri74 – 94NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri111 – 133NR C4-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-CFA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-CFA-383280 Nuclear Receptor transcription pathway
R-CFA-5362517 Signaling by Retinoic Acid

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor delta
Short name:
PPAR-delta
Alternative name(s):
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor beta
Short name:
PPAR-beta
Gene namesi
Name:PPARD
Synonyms:NR1C2, PPARB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:44835 PPARD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1932904

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504571 – 441Peroxisome proliferator-activated receptor deltaAdd BLAST441

Proteomic databases

PaxDbiQ0ZAQ8
PRIDEiQ0ZAQ8

Expressioni

Gene expression databases

BgeeiENSCAFG00000001310

Interactioni

Subunit structurei

Heterodimer with the retinoid X receptor.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001880

Chemistry databases

BindingDBiQ0ZAQ8

Structurei

3D structure databases

ProteinModelPortaliQ0ZAQ8
SMRiQ0ZAQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 439NR LBDPROSITE-ProRule annotationAdd BLAST229

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 94NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri111 – 133NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000261626
HOVERGENiHBG106004
InParanoidiQ0ZAQ8
KOiK04504
OMAiSLGMSHN
OrthoDBiEOG091G05U8
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR003075 1Cnucl_rcpt_B
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01290 PROXISOMPABR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0ZAQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPPGEAAE VREEEEKKEV AEAEGAPELN GGPERSLPSS SYTDLSRSSS
60 70 80 90 100
PPSLLDQLQM GGDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR
110 120 130 140 150
TIRMKLEYEK CERICKIQKK NRNKCQYCRF QKCVALGMSH NAIRFGRMPE
160 170 180 190 200
AEKRKLVAGL TANEGTQHNP QVADLKAFSK HIYNAYLKNF NMTKKKARGI
210 220 230 240 250
LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE ISVHVFYRCQ
260 270 280 290 300
CTTVETVREL TEFAKSIPSF SNLFLNDQVT LLKYGVHEAI FAMLASIVNK
310 320 330 340 350
DGLLVANGTG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL
360 370 380 390 400
FIAAIILCGD RPGLINVPQV EAIQDTILRA LEFHLQANHP YAQYLFPKLL
410 420 430 440
QKMADLRQLV TEHAQMMQRI KKTETETSLH PLLQEIYKDM Y
Length:441
Mass (Da):49,776
Last modified:August 22, 2006 - v1
Checksum:i901CA84AD41F4FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648277 mRNA Translation: ABG36929.1
RefSeqiNP_001041567.1, NM_001048102.1
XP_005627131.1, XM_005627074.2
XP_005627132.1, XM_005627075.2
XP_005627134.1, XM_005627077.2
UniGeneiCfa.26703

Genome annotation databases

EnsembliENSCAFT00000002032; ENSCAFP00000001880; ENSCAFG00000001310
GeneIDi481756
KEGGicfa:481756

Similar proteinsi

Entry informationi

Entry nameiPPARD_CANLF
AccessioniPrimary (citable) accession number: Q0ZAQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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