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Protein

Peroxisome proliferator-activated receptor delta

Gene

PPARD

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi70 – 14576Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri74 – 9421NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13323NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-200425. Import of palmitoyl-CoA into the mitochondrial matrix.
R-CFA-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-CFA-383280. Nuclear Receptor transcription pathway.
R-CFA-5362517. Signaling by Retinoic Acid.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor delta
Short name:
PPAR-delta
Alternative name(s):
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor beta
Short name:
PPAR-beta
Gene namesi
Name:PPARD
Synonyms:NR1C2, PPARB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1932904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Peroxisome proliferator-activated receptor deltaPRO_0000250457Add
BLAST

Proteomic databases

PaxDbiQ0ZAQ8.

Interactioni

Subunit structurei

Heterodimer with the retinoid X receptor.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001880.

Chemistry

BindingDBiQ0ZAQ8.

Structurei

3D structure databases

ProteinModelPortaliQ0ZAQ8.
SMRiQ0ZAQ8. Positions 65-151, 171-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 441188Ligand-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9421NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13323NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000129707.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiQ0ZAQ8.
KOiK04504.
OMAiHDMDTLW.
OrthoDBiEOG091G05U8.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ZAQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPPGEAAE VREEEEKKEV AEAEGAPELN GGPERSLPSS SYTDLSRSSS
60 70 80 90 100
PPSLLDQLQM GGDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR
110 120 130 140 150
TIRMKLEYEK CERICKIQKK NRNKCQYCRF QKCVALGMSH NAIRFGRMPE
160 170 180 190 200
AEKRKLVAGL TANEGTQHNP QVADLKAFSK HIYNAYLKNF NMTKKKARGI
210 220 230 240 250
LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE ISVHVFYRCQ
260 270 280 290 300
CTTVETVREL TEFAKSIPSF SNLFLNDQVT LLKYGVHEAI FAMLASIVNK
310 320 330 340 350
DGLLVANGTG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL
360 370 380 390 400
FIAAIILCGD RPGLINVPQV EAIQDTILRA LEFHLQANHP YAQYLFPKLL
410 420 430 440
QKMADLRQLV TEHAQMMQRI KKTETETSLH PLLQEIYKDM Y
Length:441
Mass (Da):49,776
Last modified:August 22, 2006 - v1
Checksum:i901CA84AD41F4FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648277 mRNA. Translation: ABG36929.1.
RefSeqiNP_001041567.1. NM_001048102.1.
XP_005627131.1. XM_005627074.2.
XP_005627132.1. XM_005627075.2.
XP_005627134.1. XM_005627077.2.
UniGeneiCfa.26703.

Genome annotation databases

EnsembliENSCAFT00000002032; ENSCAFP00000001880; ENSCAFG00000001310.
GeneIDi481756.
KEGGicfa:481756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648277 mRNA. Translation: ABG36929.1.
RefSeqiNP_001041567.1. NM_001048102.1.
XP_005627131.1. XM_005627074.2.
XP_005627132.1. XM_005627075.2.
XP_005627134.1. XM_005627077.2.
UniGeneiCfa.26703.

3D structure databases

ProteinModelPortaliQ0ZAQ8.
SMRiQ0ZAQ8. Positions 65-151, 171-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001880.

Chemistry

BindingDBiQ0ZAQ8.
ChEMBLiCHEMBL1932904.

Proteomic databases

PaxDbiQ0ZAQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000002032; ENSCAFP00000001880; ENSCAFG00000001310.
GeneIDi481756.
KEGGicfa:481756.

Organism-specific databases

CTDi5467.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000129707.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiQ0ZAQ8.
KOiK04504.
OMAiHDMDTLW.
OrthoDBiEOG091G05U8.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiR-CFA-200425. Import of palmitoyl-CoA into the mitochondrial matrix.
R-CFA-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-CFA-383280. Nuclear Receptor transcription pathway.
R-CFA-5362517. Signaling by Retinoic Acid.

Miscellaneous databases

PROiQ0ZAQ8.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPARD_CANLF
AccessioniPrimary (citable) accession number: Q0ZAQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.