Unreviewed,
UniProtKB/TrEMBL Q0ZAK1 (Q0ZAK1_HUMAN)
Last modified
January 19, 2010.
Version 26.
History...
Clusters with 100%,
90%,
50% identity |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Cellular tumor antigen p53 RuleBase RU003304V0 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) EMBL ABG49480.1 | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 155 AA. |
| Sequence status | Fragment. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity. RuleBase RU003304V0 |
| Subunit structure | Binds DNA as a homotetramer By similarity. RuleBase RU003304V0 |
| Subcellular location | Cytoplasm. Nucleus By similarity RuleBase RU003304V0. |
| Sequence similarities | Belongs to the p53 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Experimental info | ||||||||
|---|---|---|---|---|---|---|---|---|
| Non-terminal residue | 155 | 1 | EMBL ABG49480.1 | |||||
Sequences
| ||||||||||||||||||
References
| [1] | "EASI--enrichment of alternatively spliced isoforms." Venables J.P., Burn J. Nucleic Acids Res. 34:e103-e103(2006) [PubMed: 16951290] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL ABG49480.1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | DQ648884 mRNA. Translation: ABG49480.1. |
| IPI | IPI00796188. |
| UniGene | Hs.654481 |
3D structure databases | |
| SMR | Q0ZAK1. Positions 33-155. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0ZAK1. |
Organism-specific databases | |
| HGNC | HGNC:11998. TP53. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q0ZAK1. |
Family and domain databases | |
| InterPro | IPR008967. p53-like_TF_DNA-bd. IPR012346. p53/RUNT-type_TF_DNA_bd. IPR011615. p53_DNA_bd. IPR013872. p53_transactivation_domain. IPR002117. p53_tumour_Ag. IPR015551. Trp53. [Graphical view] |
| Gene3D | G3DSA:2.60.40.720. p53_RUNT_DNA_bd. 1 hit. |
| PANTHER | PTHR11447. Trp53. 1 hit. |
| Pfam | PF00870. P53. 1 hit. PF08563. P53_TAD. 1 hit. [Graphical view] |
| PRINTS | PR00386. P53SUPPRESSR. |
| ProtoNet | Search... |
Entry information
| Entry name | Q0ZAK1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q0ZAK1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Unreviewed (UniProtKB/TrEMBL) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
