ID   Q0ZAJ5_HUMAN            Unreviewed;       184 AA.
AC   Q0ZAJ5;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=MLH1-Ex(9-10) isoform {ECO:0000313|EMBL:ABG49486.1};
DE   Flags: Fragment;
GN   Name=MLH1 {ECO:0000313|EMBL:ABG49486.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABG49486.1};
RN   [1] {ECO:0000313|EMBL:ABG49486.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:ABG49486.1};
RX   PubMed=16951290; DOI=10.1093/nar/gkl592;
RA   Venables J.P., Burn J.;
RT   "EASI--enrichment of alternatively spliced isoforms.";
RL   Nucleic Acids Res. 34:e103-e103(2006).
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DR   EMBL; DQ648891; ABG49486.1; -; mRNA.
DR   AlphaFoldDB; Q0ZAJ5; -.
DR   PeptideAtlas; Q0ZAJ5; -.
DR   ChiTaRS; MLH1; human.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.30.230.10; -; 1.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE   2: Evidence at transcript level;
KW   DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204}.
FT   DOMAIN          18..59
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|Pfam:PF01119"
FT   REGION          125..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABG49486.1"
FT   NON_TER         184
FT                   /evidence="ECO:0000313|EMBL:ABG49486.1"
SQ   SEQUENCE   184 AA;  20055 MW;  BC7D6B05427BB7CD CRC64;
     LPNASTVDNI RSIFGNAVSR LEISPQNVDV NVHPTKHEVH FLHEESIPER VQQHIESKLL
     GSNPSRMYFT QTLLPGLAGP SGEMVKSTTS LTSSSTSGSS NKVYAHQMVR TDSREQKLDA
     FLQPLSKPLS SQPQAIVTED KTDISSGRAR QQDEEMLELP APAEVAAKNQ SLEGDTTKGT
     SEMS
//