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Protein

Interleukin-10

Gene

IL10

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:IL10
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000025045519 – 178Interleukin-10Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 126By similarity
Disulfide bondi80 ↔ 132By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000034416

Structurei

3D structure databases

ProteinModelPortaliQ0Z972
SMRiQ0Z972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW Eukaryota
ENOG4111PXC LUCA
GeneTreeiENSGT00510000048535
HOGENOMiHOG000072692
HOVERGENiHBG004110
InParanoidiQ0Z972
KOiK05443
OMAiPHMLREL
OrthoDBiEOG091G0Y3M
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000098 IL-10
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01294 INTRLEUKIN10
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0Z972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSSALLCCL VFLTGVRASP GQGTQSENSC THFPGSLPHM LRELRVAFSR
60 70 80 90 100
VKTFFQKKDQ LDSMLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN
110 120 130 140 150
HDPDIKEHVN SLGEKLKTFR LRLRRCHRFL PCENKSKAVV QVKNAVSKLQ
160 170
EKGIYKAMSE FDIFIDYIEA YMTMKAQN
Length:178
Mass (Da):20,474
Last modified:August 22, 2006 - v1
Checksum:iC696F055FC0FC807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ658154 mRNA Translation: ABG54456.1
RefSeqiXP_002760779.1, XM_002760733.2

Genome annotation databases

EnsembliENSCJAT00000036350; ENSCJAP00000034416; ENSCJAG00000018536
GeneIDi100386149
KEGGicjc:100386149

Similar proteinsi

Entry informationi

Entry nameiIL10_CALJA
AccessioniPrimary (citable) accession number: Q0Z972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: August 22, 2006
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health