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Protein

Bacteriocin hiracin-JM79

Gene

hirJM79

Organism
Enterococcus hirae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Bacteriocin with antibacterial activity against the Gram-positive Listeria, Enterococcus, Propionibacterium, Staphylococcus and some strains of Clostridium, Lactobacillus and Pediococcus. Lacks antibacterial activity against Gram-negative bacteria.1 Publication

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-positive bacterium Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin hiracin-JM79
Alternative name(s):
Class II sec-dependent bacteriocinImported
Gene namesi
Name:hirJM791 Publication
OrganismiEnterococcus hirae
Taxonomic identifieri1354 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 7444Bacteriocin hiracin-JM79PRO_0000352779Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0Z8B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacteriocin class IIA/YGNGV family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0Z8B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKVLKHCV ILGILGTCLA GIGTGIKVDA ATYYGNGLYC NKEKCWVDWN
60 70
QAKGEIGKII VNGWVNHGPW APRR
Length:74
Mass (Da):8,157
Last modified:August 22, 2006 - v1
Checksum:iFD9F34EC5CE57211
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321T → G AA sequence (PubMed:17326750).Curated

Mass spectrometryi

Molecular mass is 5093.7 Da from positions 30 - 74. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ664500 Genomic DNA. Translation: ABG47453.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ664500 Genomic DNA. Translation: ABG47453.1.

3D structure databases

ProteinModelPortaliQ0Z8B6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Amino acid and nucleotide sequence, adjacent genes, and heterologous expression of hiracin JM79, a sec-dependent bacteriocin produced by Enterococcus hirae DCH5, isolated from Mallard ducks (Anas platyrhynchos)."
    Sanchez J., Diep D.B., Herranz C., Nes I.F., Cintas L.M., Hernandez P.E.
    FEMS Microbiol. Lett. 270:227-236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-72, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
    Strain: DCH5Imported.

Entry informationi

Entry nameiHJM79_ENTHR
AccessioniPrimary (citable) accession number: Q0Z8B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 22, 2006
Last modified: December 9, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.