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Protein

Fatty acid-binding protein 9

Gene

FABP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31545-MONOMER.
ReactomeiR-HSA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein 9
Alternative name(s):
Testis lipid-binding protein
Short name:
TLBP
Testis-type fatty acid-binding protein
Short name:
T-FABP
Gene namesi
Name:FABP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:3563. FABP9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi646480.
OpenTargetsiENSG00000205186.
PharmGKBiPA27964.

Polymorphism and mutation databases

BioMutaiFABP9.
DMDMi121948152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172921 – 132Fatty acid-binding protein 9Add BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei91PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0Z7S8.
PeptideAtlasiQ0Z7S8.
PRIDEiQ0Z7S8.

PTM databases

iPTMnetiQ0Z7S8.
PhosphoSitePlusiQ0Z7S8.

Expressioni

Gene expression databases

CleanExiHS_FABP9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368362.

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi7 – 16Combined sources10
Helixi17 – 24Combined sources8
Helixi28 – 34Combined sources7
Beta strandi40 – 46Combined sources7
Beta strandi49 – 56Combined sources8
Beta strandi59 – 65Combined sources7
Beta strandi71 – 74Combined sources4
Beta strandi80 – 88Combined sources9
Beta strandi91 – 98Combined sources8
Beta strandi101 – 110Combined sources10
Beta strandi113 – 120Combined sources8
Beta strandi123 – 130Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A60X-ray1.53A1-132[»]
ProteinModelPortaliQ0Z7S8.
SMRiQ0Z7S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ0Z7S8.
OMAiMNNIVST.
OrthoDBiEOG091G0QSV.
PhylomeDBiQ0Z7S8.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0Z7S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEPFLGTWK LVSSENFEDY MKELGVNFAA RNMAGLVKPT VTISVDGKMM
60 70 80 90 100
TIRTESSFQD TKISFKLGEE FDETTADNRK VKSTITLENG SMIHVQKWLG
110 120 130
KETTIKRKIV DEKMVVECKM NNIVSTRIYE KV
Length:132
Mass (Da):15,093
Last modified:August 22, 2006 - v1
Checksum:iB189DA5EB0B234FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ821473 Genomic DNA. Translation: ABG49443.1.
CH471068 Genomic DNA. Translation: EAW87091.1.
RefSeqiNP_001073995.1. NM_001080526.1.
UniGeneiHs.653176.

Genome annotation databases

EnsembliENST00000379071; ENSP00000368362; ENSG00000205186.
GeneIDi646480.
KEGGihsa:646480.
UCSCiuc011lfo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ821473 Genomic DNA. Translation: ABG49443.1.
CH471068 Genomic DNA. Translation: EAW87091.1.
RefSeqiNP_001073995.1. NM_001080526.1.
UniGeneiHs.653176.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A60X-ray1.53A1-132[»]
ProteinModelPortaliQ0Z7S8.
SMRiQ0Z7S8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368362.

PTM databases

iPTMnetiQ0Z7S8.
PhosphoSitePlusiQ0Z7S8.

Polymorphism and mutation databases

BioMutaiFABP9.
DMDMi121948152.

Proteomic databases

PaxDbiQ0Z7S8.
PeptideAtlasiQ0Z7S8.
PRIDEiQ0Z7S8.

Protocols and materials databases

DNASUi646480.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379071; ENSP00000368362; ENSG00000205186.
GeneIDi646480.
KEGGihsa:646480.
UCSCiuc011lfo.3. human.

Organism-specific databases

CTDi646480.
DisGeNETi646480.
GeneCardsiFABP9.
HGNCiHGNC:3563. FABP9.
neXtProtiNX_Q0Z7S8.
OpenTargetsiENSG00000205186.
PharmGKBiPA27964.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ0Z7S8.
OMAiMNNIVST.
OrthoDBiEOG091G0QSV.
PhylomeDBiQ0Z7S8.
TreeFamiTF316894.

Enzyme and pathway databases

BioCyciZFISH:G66-31545-MONOMER.
ReactomeiR-HSA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

GenomeRNAii646480.
PROiQ0Z7S8.

Gene expression databases

CleanExiHS_FABP9.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABP9_HUMAN
AccessioniPrimary (citable) accession number: Q0Z7S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.