ID   Q0X0E6_MOUSE            Unreviewed;       138 AA.
AC   Q0X0E6;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   03-MAR-2009, entry version 24.
DE   SubName: Full=Tumor necrosis factor alpha;
DE   Flags: Fragment;
GN   Name=Tnf; Synonyms=TNFA;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CTS/Shi, and NOD/Shi;
RA   Inoue K., Ikegami H., Fujisawa T., Noso S., Babaya N., Ogihara T.;
RT   "Tnfa sequences.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AB185895; BAF02299.1; -; Genomic_DNA.
DR   EMBL; AB185896; BAF02300.1; -; Genomic_DNA.
DR   IPI; IPI00128861; -.
DR   UniGene; Mm.1293; -.
DR   SMR; Q0X0E6; 1-138.
DR   Ensembl; ENSMUSG00000024401; Mus musculus.
DR   MGI; MGI:104798; Tnf.
DR   HOVERGEN; Q0X0E6; -.
DR   ArrayExpress; Q0X0E6; -.
DR   Bgee; Q0X0E6; -.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:MGI.
DR   GO; GO:0030141; C:secretory granule; TAS:MGI.
DR   GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR   GO; GO:0042802; F:identical protein binding; IEA:Compara.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IDA:MGI.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IPI:MGI.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; TAS:MGI.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Compara.
DR   GO; GO:0006916; P:anti-apoptosis; IEA:Compara.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Compara.
DR   GO; GO:0006919; P:activation of caspase activity; IEA:Compara.
DR   GO; GO:0001775; P:cell activation; IEA:Compara.
DR   GO; GO:0002439; P:chronic inflammatory response to antigenic ...; IEA:Compara.
DR   GO; GO:0042742; P:defense response to bacterium; IDA:MGI.
DR   GO; GO:0006006; P:glucose metabolic process; IDA:MGI.
DR   GO; GO:0006959; P:humoral immune response; IMP:MGI.
DR   GO; GO:0008625; P:induction of apoptosis via death domain rec...; IGI:MGI.
DR   GO; GO:0050901; P:leukocyte tethering or rolling; IEA:Compara.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
DR   GO; GO:0002740; P:negative regulation of cytokine secretion d...; IEA:Compara.
DR   GO; GO:0046325; P:negative regulation of glucose import; IDA:MGI.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 produc...; IEA:Compara.
DR   GO; GO:0002037; P:negative regulation of L-glutamate transport; IEA:Compara.
DR   GO; GO:0000122; P:negative regulation of transcription from R...; IDA:MGI.
DR   GO; GO:0045071; P:negative regulation of viral genome replica...; IEA:Compara.
DR   GO; GO:0009887; P:organ morphogenesis; IMP:MGI.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthet...; IEA:Compara.
DR   GO; GO:0032722; P:positive regulation of chemokine production; IEA:Compara.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Compara.
DR   GO; GO:0043193; P:positive regulation of gene-specific transc...; IEA:Compara.
DR   GO; GO:0034116; P:positive regulation of heterotypic cell-cel...; IEA:Compara.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; IDA:MGI.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IDA:MGI.
DR   GO; GO:0045840; P:positive regulation of mitosis; IEA:Compara.
DR   GO; GO:0043525; P:positive regulation of neuron apoptosis; IEA:Compara.
DR   GO; GO:0042346; P:positive regulation of NF-kappaB import int...; IEA:Compara.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcript...; IEA:Compara.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynt...; IEA:Compara.
DR   GO; GO:0001934; P:positive regulation of protein amino acid p...; IEA:Compara.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell p...; IEA:Compara.
DR   GO; GO:0050806; P:positive regulation of synaptic transmission; IEA:Compara.
DR   GO; GO:0045944; P:positive regulation of transcription from R...; IDA:MGI.
DR   GO; GO:0045994; P:positive regulation of translational initia...; IDA:MGI.
DR   GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Compara.
DR   GO; GO:0032800; P:receptor biosynthetic process; IEA:Compara.
DR   GO; GO:0051023; P:regulation of immunoglobulin secretion; IDA:MGI.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Compara.
DR   GO; GO:0045670; P:regulation of osteoclast differentiation; IDA:MGI.
DR   GO; GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
DR   GO; GO:0009612; P:response to mechanical stimulus; IEA:Compara.
DR   GO; GO:0009615; P:response to virus; IEA:Compara.
DR   GO; GO:0006927; P:transformed cell apoptosis; TAS:MGI.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pa...; IEA:Compara.
DR   InterPro; IPR006053; TNF_abc.
DR   InterPro; IPR002959; TNF_alpha.
DR   InterPro; IPR006052; TNF_family.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like.
DR   Gene3D; G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   PRINTS; PR01235; TNFALPHA.
DR   ProDom; PD002012; TNF_subf; 1.
DR   SMART; SM00207; TNF; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Membrane.
FT   NON_TER       1      1
SQ   SEQUENCE   138 AA;  15394 MW;  14FB32C50CA144BD CRC64;
     NHQVEEQLEW LSQRANALLA NGMDLKDNQL VVPADGLYLV YSQVLFKGQG CPDYVLLTHT
     VSRFAISYQE KVNLLSAVKS PCPKDTPEGA ELKPWYEPIY LGGVFQLEKG DQLSAEVNLP
     KYLDFAESGQ VYFGVIAL
//