Unreviewed, UniProtKB/TrEMBL Q0X0E6 (Q0X0E6_MOUSE)

Names and origin

Protein names

Submitted name:
    Tumor necrosis factor alpha EMBL BAF02300.1

Gene names

Name:	Tnf MGI 104798
Synonyms:	TNFA EMBL BAF02300.1

Organism

Mus musculus (Mouse) EMBL BAF02300.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	138 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Cellular component	Membrane Spearmint SPM008983
Molecular function	Cytokine Spearmint SPM008983
Gene Ontology (GO)
Biological process	activation of MAPK activity Inferred from electronic annotation. Source: Compara activation of caspase activity Inferred from electronic annotation. Source: Compara anti-apoptosis Inferred from electronic annotation. Source: Compara calcium-mediated signaling Inferred from electronic annotation. Source: Compara cell activation Inferred from electronic annotation. Source: Compara chronic inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara defense response to bacterium Inferred from direct assay. Source: MGI glucose metabolic process Inferred from direct assay. Source: MGI humoral immune response Inferred from mutant phenotype. Source: MGI induction of apoptosis via death domain receptors Inferred from genetic interaction. Source: MGI leukocyte tethering or rolling Inferred from electronic annotation. Source: Compara negative regulation of L-glutamate transport Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of cytokine secretion during immune response Inferred from electronic annotation. Source: Compara negative regulation of glucose import Inferred from direct assay. Source: MGI negative regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI negative regulation of viral genome replication Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from mutant phenotype. Source: MGI positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay. Source: MGI positive regulation of JNK cascade Inferred from direct assay. Source: MGI positive regulation of NF-kappaB import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of chemokine biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of chemokine production Inferred from electronic annotation. Source: Compara positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of gene-specific transcription Inferred from electronic annotation. Source: Compara positive regulation of heterotypic cell-cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of neuron apoptosis Inferred from electronic annotation. Source: Compara positive regulation of nitric oxide biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of protein amino acid phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI positive regulation of translational initiation by iron Inferred from direct assay. Source: MGI protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara receptor biosynthetic process Inferred from electronic annotation. Source: Compara regulation of immunoglobulin secretion Inferred from direct assay. Source: MGI regulation of insulin secretion Inferred from electronic annotation. Source: Compara regulation of osteoclast differentiation Inferred from direct assay. Source: MGI response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to mechanical stimulus Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara transformed cell apoptosis Traceable author statement. Source: MGI tumor necrosis factor-mediated signaling pathway Inferred from electronic annotation. Source: Compara
Cellular component	extracellular space Inferred from direct assay. Source: MGI integral to plasma membrane Traceable author statement. Source: MGI secretory granule Traceable author statement. Source: MGI
Molecular function	cytokine activity Inferred from direct assay. Source: MGI identical protein binding Inferred from electronic annotation. Source: Compara tumor necrosis factor receptor binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAF02300.1

Sequences

	Sequence		Length	Mass (Da)
	Q0X0E6-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 14FB32C50CA144BD	FASTA	138	15,394
	10 20 30 40 50 60 NHQVEEQLEW LSQRANALLA NGMDLKDNQL VVPADGLYLV YSQVLFKGQG CPDYVLLTHT 70 80 90 100 110 120 VSRFAISYQE KVNLLSAVKS PCPKDTPEGA ELKPWYEPIY LGGVFQLEKG DQLSAEVNLP 130 KYLDFAESGQ VYFGVIAL

References

[1]	"Tnfa sequences." Inoue K., Ikegami H., Fujisawa T., Noso S., Babaya N., Ogihara T. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CTS/Shi EMBL BAF02300.1 and NOD/Shi EMBL BAF02299.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB185895 Genomic DNA. Translation: BAF02299.1. AB185896 Genomic DNA. Translation: BAF02300.1.
IPI	IPI00128861.
UniGene	Mm.1293
3D structure databases
SMR	Q0X0E6. Positions 1-138.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000024401. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:104798. Tnf.
Phylogenomic databases
HOVERGEN	Q0X0E6.
Gene expression databases
ArrayExpress	Q0X0E6.
Bgee	Q0X0E6.
Family and domain databases
InterPro	IPR006053. TNF_abc. IPR002959. TNF_alpha. IPR006052. TNF_family. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00229. TNF. 1 hit. [Graphical view]
PRINTS	PR01234. TNECROSISFCT. PR01235. TNFALPHA.
ProDom	PD002012. TNF_subf. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00207. TNF. 1 hit. [Graphical view]
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q0X0E6_MOUSE

Accession

Primary (citable) accession number: Q0X0E6

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	March 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)