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Q0WX57

- U17LO_HUMAN

UniProt

Q0WX57 - U17LO_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

Gene

USP17L24

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Nucleophile
    Active sitei334 – 3341Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 17
    Ubiquitin thioesterase 17
    Ubiquitin-specific-processing protease 17
    Gene namesi
    Name:USP17L24
    Synonyms:USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
    AND
    AND
    AND
    AND
    AND
    AND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:44453. USP17L24.
    HGNC:44452. USP17L25.
    HGNC:44454. USP17L26.
    HGNC:44455. USP17L27.
    HGNC:44456. USP17L28.
    HGNC:44457. USP17L29.
    HGNC:44458. USP17L30.

    Subcellular locationi

    Nucleusnucleolus 1 Publication. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi89 – 891C → S: Abolishes enzymatic activity. Loss of the pro-apoptotic function. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Ubiquitin carboxyl-terminal hydrolase 17-like protein 24PRO_0000331643Add
    BLAST

    Proteomic databases

    PaxDbiQ0WX57.
    PRIDEiQ0WX57.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, liver and skeletal muscle.1 Publication

    Gene expression databases

    GenevestigatoriQ0WX57.

    Organism-specific databases

    HPAiHPA045642.

    Interactioni

    Protein-protein interaction databases

    IntActiQ0WX57. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0WX57.
    SMRiQ0WX57. Positions 49-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 375296USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP17 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOVERGENiHBG007129.
    InParanoidiQ0WX57.
    KOiK11845.
    OMAiQITLDQW.
    OrthoDBiEOG73NG35.
    PhylomeDBiQ0WX57.

    Family and domain databases

    InterProiIPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0WX57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD    50
    LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY 100
    TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA 150
    AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY 200
    WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN 250
    AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC 300
    LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD 350
    DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD 400
    RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF 450
    NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM 500
    NTGTLASLRG RARRSKGKNK HSKRALLVCQ 530
    Length:530
    Mass (Da):59,711
    Last modified:April 29, 2008 - v2
    Checksum:i5B0DC65280B2A098
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91R → G in AAO38845. (PubMed:17109758)Curated
    Sequence conflicti9 – 91R → G in AAQ11741. (PubMed:17109758)Curated
    Sequence conflicti9 – 91R → G in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti23 – 231S → P in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti262 – 2621P → S in AAQ11741. (PubMed:17109758)Curated
    Sequence conflicti310 – 3101P → Q in AAQ11741. (PubMed:17109758)Curated
    Sequence conflicti310 – 3101P → Q in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti360 – 3601T → I in AAO38845. (PubMed:17109758)Curated
    Sequence conflicti361 – 3611S → P in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti364 – 3641S → T in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti392 – 3921R → S in AAO38845. (PubMed:17109758)Curated
    Sequence conflicti398 – 3981D → A in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti430 – 4301Q → H in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti492 – 4921S → T in AAO38845. (PubMed:17109758)Curated
    Sequence conflicti492 – 4921S → T in AAQ11741. (PubMed:17109758)Curated
    Sequence conflicti492 – 4921S → T in AAQ11742. (PubMed:17109758)Curated
    Sequence conflicti511 – 5111R → G in AAQ11742. (PubMed:17109758)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF544011 mRNA. Translation: AAQ11741.1.
    AF544012 mRNA. Translation: AAQ11742.1.
    AY188990 mRNA. Translation: AAO38845.1.
    AC116655 Genomic DNA. No translation available.
    RefSeqiNP_001229255.1. NM_001242326.1.
    NP_001229256.1. NM_001242327.1.
    NP_001229257.1. NM_001242328.1.
    NP_001229259.1. NM_001242330.1.
    NP_001229260.1. NM_001242331.1.
    NP_001229261.1. NM_001242332.1.
    NP_001243796.1. NM_001256867.1.
    UniGeneiHs.553810.
    Hs.631527.
    Hs.722783.
    Hs.723053.
    Hs.741133.

    Genome annotation databases

    EnsembliENST00000504104; ENSP00000422887; ENSG00000228856.
    ENST00000504481; ENSP00000425375; ENSG00000232264.
    ENST00000504543; ENSP00000423777; ENSG00000231051.
    ENST00000509271; ENSP00000422097; ENSG00000230430.
    ENST00000509660; ENSP00000427366; ENSG00000229579.
    ENST00000511681; ENSP00000422969; ENSG00000231637.
    ENST00000515574; ENSP00000423211; ENSG00000235780.
    GeneIDi728369.
    728373.
    728379.
    728393.
    728400.
    728405.
    728419.
    KEGGihsa:728369.
    hsa:728373.
    hsa:728379.
    hsa:728393.
    hsa:728400.
    hsa:728405.
    hsa:728419.
    UCSCiuc021xll.1. human.

    Polymorphism databases

    DMDMi187663978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF544011 mRNA. Translation: AAQ11741.1 .
    AF544012 mRNA. Translation: AAQ11742.1 .
    AY188990 mRNA. Translation: AAO38845.1 .
    AC116655 Genomic DNA. No translation available.
    RefSeqi NP_001229255.1. NM_001242326.1.
    NP_001229256.1. NM_001242327.1.
    NP_001229257.1. NM_001242328.1.
    NP_001229259.1. NM_001242330.1.
    NP_001229260.1. NM_001242331.1.
    NP_001229261.1. NM_001242332.1.
    NP_001243796.1. NM_001256867.1.
    UniGenei Hs.553810.
    Hs.631527.
    Hs.722783.
    Hs.723053.
    Hs.741133.

    3D structure databases

    ProteinModelPortali Q0WX57.
    SMRi Q0WX57. Positions 49-372.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q0WX57. 6 interactions.

    Protein family/group databases

    MEROPSi C19.023.

    Polymorphism databases

    DMDMi 187663978.

    Proteomic databases

    PaxDbi Q0WX57.
    PRIDEi Q0WX57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000504104 ; ENSP00000422887 ; ENSG00000228856 .
    ENST00000504481 ; ENSP00000425375 ; ENSG00000232264 .
    ENST00000504543 ; ENSP00000423777 ; ENSG00000231051 .
    ENST00000509271 ; ENSP00000422097 ; ENSG00000230430 .
    ENST00000509660 ; ENSP00000427366 ; ENSG00000229579 .
    ENST00000511681 ; ENSP00000422969 ; ENSG00000231637 .
    ENST00000515574 ; ENSP00000423211 ; ENSG00000235780 .
    GeneIDi 728369.
    728373.
    728379.
    728393.
    728400.
    728405.
    728419.
    KEGGi hsa:728369.
    hsa:728373.
    hsa:728379.
    hsa:728393.
    hsa:728400.
    hsa:728405.
    hsa:728419.
    UCSCi uc021xll.1. human.

    Organism-specific databases

    CTDi 728369.
    728373.
    728379.
    728393.
    728400.
    728405.
    728419.
    GeneCardsi GC04P009327.
    GC04P009333.
    GC04P009338.
    GC04P009347.
    GC04P009352.
    GC04P009357.
    GC04P009372.
    H-InvDB HIX0163954.
    HIX0163955.
    HGNCi HGNC:44453. USP17L24.
    HGNC:44452. USP17L25.
    HGNC:44454. USP17L26.
    HGNC:44455. USP17L27.
    HGNC:44456. USP17L28.
    HGNC:44457. USP17L29.
    HGNC:44458. USP17L30.
    HPAi HPA045642.
    MIMi 607011. gene.
    neXtProti NX_Q0WX57.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5533.
    HOVERGENi HBG007129.
    InParanoidi Q0WX57.
    KOi K11845.
    OMAi QITLDQW.
    OrthoDBi EOG73NG35.
    PhylomeDBi Q0WX57.

    Miscellaneous databases

    NextBioi 126977.
    PROi Q0WX57.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q0WX57.

    Family and domain databases

    InterProi IPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter."
      Saitoh Y., Miyamoto N., Okada T., Gondo Y., Showguchi-Miyata J., Hadano S., Ikeda J.-E.
      Genomics 67:291-300(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-89.
    2. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
      Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
      BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-89.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene."
      Okada T., Gondo Y., Goto J., Kanazawa I., Hadano S., Ikeda J.E.
      Hum. Genet. 110:302-313(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
      Burrows J.F., McGrattan M.J., Johnston J.A.
      Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.
    6. "The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster."
      Burrows J.F., Scott C.J., Johnston J.A.
      BMC Genomics 11:250-250(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiU17LO_HUMAN
    AccessioniPrimary (citable) accession number: Q0WX57
    Secondary accession number(s): A8MRA9, Q0WX56, Q3BEM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3