Ubiquitin carboxyl-terminal hydrolase 17

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase 17
    Ubiquitin-specific-processing protease 17
    Deubiquitinating enzyme 17

Gene names

Name:	USP17A
Synonyms:	USP17
AND
Name:	USP17H
Synonyms:	USP17
AND
Name:	USP17I
Synonyms:	USP17
AND
Name:	USP17J
Synonyms:	USP17
AND
Name:	USP17K
Synonyms:	USP17
AND
Name:	USP17L
Synonyms:	USP17
AND
Name:	USP17M
Synonyms:	USP17

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates. May also bind hyaluronan and RNA. Ref.1
Catalytic activity	Ubiquitin C-terminal thioester + H₂O = ubiquitin + a thiol. Ref.1 Ref.2
Subcellular location	Nucleus › nucleolus. Ref.2
Tissue specificity	Expressed in heart, brain, liver and skeletal muscle. Ref.1
Sequence similarities	Belongs to the peptidase C19 family. USP17 subfamily.
Caution	The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found both on chromosome 4 and chromosome 8.

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Ontologies

Keywords
Biological process	Apoptosis Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 530

530

Ubiquitin carboxyl-terminal hydrolase 17

PRO_0000331643

Sites

Active site

89

1

Active site

325

1

By similarity

Active site

334

1

By similarity

Experimental info

Mutagenesis

89

1

C → S: Abolishes enzymatic activity. Loss of the pro-apoptotic function. Ref.1 Ref.2

Sequence conflict

9

1

R → G in AAO38845. Ref.2

Sequence conflict

9

1

R → G in AAQ11741. Ref.2

Sequence conflict

9

1

R → G in AAQ11742. Ref.2

Sequence conflict

23

1

S → P in AAQ11742. Ref.2

Sequence conflict

262

1

P → S in AAQ11741. Ref.2

Sequence conflict

310

1

P → Q in AAQ11741. Ref.2

Sequence conflict

310

1

P → Q in AAQ11742. Ref.2

Sequence conflict

360

1

T → I in AAO38845. Ref.2

Sequence conflict

361

1

S → P in AAQ11742. Ref.2

Sequence conflict

364

1

S → T in AAQ11742. Ref.2

Sequence conflict

392

1

R → S in AAO38845. Ref.2

Sequence conflict

398

1

D → A in AAQ11742. Ref.2

Sequence conflict

430

1

Q → H in AAQ11742. Ref.2

Sequence conflict

492

1

S → T in AAO38845. Ref.2

Sequence conflict

492

1

S → T in AAQ11741. Ref.2

Sequence conflict

492

1

S → T in AAQ11742. Ref.2

Sequence conflict

511

1

R → G in AAQ11742. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

Q0WX57-1 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: 5B0DC65280B2A098
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FASTA

530

59,711

        10         20         30         40         50         60 
MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR 

        70         80         90        100        110        120 
QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY TPPLANYMLS REHSQTCHRH 

       130        140        150        160        170        180 
KGCMLCTMQA HITRALHNPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMKKACLPGH 

       190        200        210        220        230        240 
KQVDHHSKDT TLIHQIFGGY WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL 

       250        260        270        280        290        300 
VKPEELNGEN AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC 

       310        320        330        340        350        360 
LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD DAEVTASSIT 

       370        380        390        400        410        420 
SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRATQGELKR DHPCLQAPEL 

       430        440        450        460        470        480 
DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP 

       490        500        510        520        530 
EQQSSLLNLS SSTPTHQESM NTGTLASLRG RARRSKGKNK HSKRALLVCQ

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter." Saitoh Y., Miyamoto N., Okada T., Gondo Y., Showguchi-Miyata J., Hadano S., Ikeda J.-E. Genomics 67:291-300(2000) [PubMed: 10936051] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-89.
[2]	"Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability." Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H. BMC Genomics 7:292-292(2006) [PubMed: 17109758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-89.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene." Okada T., Gondo Y., Goto J., Kanazawa I., Hadano S., Ikeda J.E. Hum. Genet. 110:302-313(2002) [PubMed: 11941478] [Abstract] Cited for: IDENTIFICATION.
[5]	"The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence." Burrows J.F., McGrattan M.J., Johnston J.A. Genomics 85:524-529(2005) [PubMed: 15780755] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.

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Cross-references

Sequence databases
	AF544011 mRNA. Translation: AAQ11741.1. AF544012 mRNA. Translation: AAQ11742.1. AY188990 mRNA. Translation: AAO38845.1. AC116655 Genomic DNA. No translation available.
IPI	IPI00736155.
RefSeq	XP_001130410.1. XP_001130417.1. XP_001130428.1. XP_001130444.1. XP_001130452.1. XP_001130464.1. XP_001130476.1.
UniGene	Hs.553810 Hs.631527
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000182945. Homo sapiens. [Contig view]
GeneID	728369. 728373. 728379. 728393. 728400. 728405. 728419.
KEGG	hsa:728369. hsa:728373. hsa:728379. hsa:728393. hsa:728400. hsa:728405. hsa:728419.
UCSC	uc003glq.2. human.
Organism-specific databases
GeneCards	GC04P008935. GC04P008940. GC04P008945. GC04P008954. GC04P008959. GC04P008964. GC04P008971. GC04P008974. GC08M012032.
HGNC	HGNC:12615. USP17.
MIM	607011. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q0WX57.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	126977.
SOURCE	Search...

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Entry information

Entry name

UBP17_HUMAN

Accession

Primary (citable) accession number: Q0WX57
Secondary accession number(s): A8MRA9, Q0WX56, Q3BEM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	July 7, 2009
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other Resources

Entry information

Relevant documents