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Q0WX57

- U17LO_HUMAN

UniProt

Q0WX57 - U17LO_HUMAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

Gene

USP17L24

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Nucleophile
Active sitei334 – 3341Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
Gene namesi
Name:USP17L24
Synonyms:USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
AND
AND
AND
AND
AND
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:44453. USP17L24.
HGNC:44452. USP17L25.
HGNC:44454. USP17L26.
HGNC:44455. USP17L27.
HGNC:44456. USP17L28.
HGNC:44457. USP17L29.
HGNC:44458. USP17L30.

Subcellular locationi

Nucleusnucleolus 1 Publication. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi89 – 891C → S: Abolishes enzymatic activity. Loss of the pro-apoptotic function. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Ubiquitin carboxyl-terminal hydrolase 17-like protein 24PRO_0000331643Add
BLAST

Proteomic databases

PaxDbiQ0WX57.
PRIDEiQ0WX57.

Expressioni

Tissue specificityi

Expressed in heart, brain, liver and skeletal muscle.1 Publication

Gene expression databases

GenevestigatoriQ0WX57.

Organism-specific databases

HPAiHPA045642.

Interactioni

Protein-protein interaction databases

IntActiQ0WX57. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ0WX57.
SMRiQ0WX57. Positions 49-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 375296USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00760000119279.
HOVERGENiHBG007129.
InParanoidiQ0WX57.
KOiK11845.
OMAiQITLDQW.
OrthoDBiEOG73NG35.
PhylomeDBiQ0WX57.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WX57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY
110 120 130 140 150
TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA
160 170 180 190 200
AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY
210 220 230 240 250
WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN
260 270 280 290 300
AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC
310 320 330 340 350
LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM
510 520 530
NTGTLASLRG RARRSKGKNK HSKRALLVCQ
Length:530
Mass (Da):59,711
Last modified:April 29, 2008 - v2
Checksum:i5B0DC65280B2A098
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91R → G in AAO38845. (PubMed:17109758)Curated
Sequence conflicti9 – 91R → G in AAQ11741. (PubMed:17109758)Curated
Sequence conflicti9 – 91R → G in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti23 – 231S → P in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti262 – 2621P → S in AAQ11741. (PubMed:17109758)Curated
Sequence conflicti310 – 3101P → Q in AAQ11741. (PubMed:17109758)Curated
Sequence conflicti310 – 3101P → Q in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti360 – 3601T → I in AAO38845. (PubMed:17109758)Curated
Sequence conflicti361 – 3611S → P in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti364 – 3641S → T in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti392 – 3921R → S in AAO38845. (PubMed:17109758)Curated
Sequence conflicti398 – 3981D → A in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti430 – 4301Q → H in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti492 – 4921S → T in AAO38845. (PubMed:17109758)Curated
Sequence conflicti492 – 4921S → T in AAQ11741. (PubMed:17109758)Curated
Sequence conflicti492 – 4921S → T in AAQ11742. (PubMed:17109758)Curated
Sequence conflicti511 – 5111R → G in AAQ11742. (PubMed:17109758)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544011 mRNA. Translation: AAQ11741.1.
AF544012 mRNA. Translation: AAQ11742.1.
AY188990 mRNA. Translation: AAO38845.1.
AC116655 Genomic DNA. No translation available.
RefSeqiNP_001229255.1. NM_001242326.1.
NP_001229256.1. NM_001242327.1.
NP_001229257.1. NM_001242328.1.
NP_001229259.1. NM_001242330.1.
NP_001229260.1. NM_001242331.1.
NP_001229261.1. NM_001242332.1.
NP_001243796.1. NM_001256867.1.
UniGeneiHs.553810.
Hs.631527.
Hs.722783.
Hs.723053.
Hs.741133.

Genome annotation databases

EnsembliENST00000504104; ENSP00000422887; ENSG00000228856.
ENST00000504481; ENSP00000425375; ENSG00000232264.
ENST00000504543; ENSP00000423777; ENSG00000231051.
ENST00000509271; ENSP00000422097; ENSG00000230430.
ENST00000509660; ENSP00000427366; ENSG00000229579.
ENST00000511681; ENSP00000422969; ENSG00000231637.
ENST00000515574; ENSP00000423211; ENSG00000235780.
GeneIDi728369.
728373.
728379.
728393.
728400.
728405.
728419.
KEGGihsa:728369.
hsa:728373.
hsa:728379.
hsa:728393.
hsa:728400.
hsa:728405.
hsa:728419.
UCSCiuc021xll.1. human.

Polymorphism databases

DMDMi187663978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544011 mRNA. Translation: AAQ11741.1 .
AF544012 mRNA. Translation: AAQ11742.1 .
AY188990 mRNA. Translation: AAO38845.1 .
AC116655 Genomic DNA. No translation available.
RefSeqi NP_001229255.1. NM_001242326.1.
NP_001229256.1. NM_001242327.1.
NP_001229257.1. NM_001242328.1.
NP_001229259.1. NM_001242330.1.
NP_001229260.1. NM_001242331.1.
NP_001229261.1. NM_001242332.1.
NP_001243796.1. NM_001256867.1.
UniGenei Hs.553810.
Hs.631527.
Hs.722783.
Hs.723053.
Hs.741133.

3D structure databases

ProteinModelPortali Q0WX57.
SMRi Q0WX57. Positions 49-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q0WX57. 6 interactions.

Protein family/group databases

MEROPSi C19.023.

Polymorphism databases

DMDMi 187663978.

Proteomic databases

PaxDbi Q0WX57.
PRIDEi Q0WX57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000504104 ; ENSP00000422887 ; ENSG00000228856 .
ENST00000504481 ; ENSP00000425375 ; ENSG00000232264 .
ENST00000504543 ; ENSP00000423777 ; ENSG00000231051 .
ENST00000509271 ; ENSP00000422097 ; ENSG00000230430 .
ENST00000509660 ; ENSP00000427366 ; ENSG00000229579 .
ENST00000511681 ; ENSP00000422969 ; ENSG00000231637 .
ENST00000515574 ; ENSP00000423211 ; ENSG00000235780 .
GeneIDi 728369.
728373.
728379.
728393.
728400.
728405.
728419.
KEGGi hsa:728369.
hsa:728373.
hsa:728379.
hsa:728393.
hsa:728400.
hsa:728405.
hsa:728419.
UCSCi uc021xll.1. human.

Organism-specific databases

CTDi 728369.
728373.
728379.
728393.
728400.
728405.
728419.
GeneCardsi GC04P009327.
GC04P009333.
GC04P009338.
GC04P009347.
GC04P009352.
GC04P009357.
GC04P009372.
H-InvDB HIX0163954.
HIX0163955.
HGNCi HGNC:44453. USP17L24.
HGNC:44452. USP17L25.
HGNC:44454. USP17L26.
HGNC:44455. USP17L27.
HGNC:44456. USP17L28.
HGNC:44457. USP17L29.
HGNC:44458. USP17L30.
HPAi HPA045642.
MIMi 607011. gene.
neXtProti NX_Q0WX57.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00760000119279.
HOVERGENi HBG007129.
InParanoidi Q0WX57.
KOi K11845.
OMAi QITLDQW.
OrthoDBi EOG73NG35.
PhylomeDBi Q0WX57.

Miscellaneous databases

NextBioi 126977.
PROi Q0WX57.
SOURCEi Search...

Gene expression databases

Genevestigatori Q0WX57.

Family and domain databases

InterProi IPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter."
    Saitoh Y., Miyamoto N., Okada T., Gondo Y., Showguchi-Miyata J., Hadano S., Ikeda J.-E.
    Genomics 67:291-300(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-89.
  2. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
    Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
    BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-89.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene."
    Okada T., Gondo Y., Goto J., Kanazawa I., Hadano S., Ikeda J.E.
    Hum. Genet. 110:302-313(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
    Burrows J.F., McGrattan M.J., Johnston J.A.
    Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.
  6. "The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster."
    Burrows J.F., Scott C.J., Johnston J.A.
    BMC Genomics 11:250-250(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiU17LO_HUMAN
AccessioniPrimary (citable) accession number: Q0WX57
Secondary accession number(s): A8MRA9, Q0WX56, Q3BEM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3