Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

Gene

USP17L24

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Nucleophile1
Active sitei334Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:G66-33259-MONOMER.
ReactomeiR-HSA-5689880. Ub-specific processing proteases.

Protein family/group databases

MEROPSiC19.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
Gene namesi
Name:USP17L24
Synonyms:USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
AND
AND
AND
AND
AND
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:44453. USP17L24.
HGNC:44452. USP17L25.
HGNC:44454. USP17L26.
HGNC:44455. USP17L27.
HGNC:44456. USP17L28.
HGNC:44457. USP17L29.
HGNC:44458. USP17L30.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi89C → S: Abolishes enzymatic activity. Loss of the pro-apoptotic function. 2 Publications1

Organism-specific databases

DisGeNETi728369.
728373.
728379.
728393.
728400.
728405.
728419.
OpenTargetsiENSG00000228856.
ENSG00000229579.
ENSG00000230430.
ENSG00000231051.
ENSG00000231637.
ENSG00000232264.
ENSG00000235780.

Polymorphism and mutation databases

BioMutaiUSP17L24.
DMDMi187663978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316431 – 530Ubiquitin carboxyl-terminal hydrolase 17-like protein 24Add BLAST530

Proteomic databases

PaxDbiQ0WX57.
PeptideAtlasiQ0WX57.
PRIDEiQ0WX57.

PTM databases

iPTMnetiQ0WX57.
PhosphoSitePlusiQ0WX57.

Expressioni

Tissue specificityi

Expressed in heart, brain, liver and skeletal muscle.1 Publication

Gene expression databases

ExpressionAtlasiQ0WX57. differential.

Organism-specific databases

HPAiHPA045642.

Interactioni

Protein-protein interaction databases

IntActiQ0WX57. 6 interactors.
STRINGi9606.ENSP00000427366.

Structurei

3D structure databases

ProteinModelPortaliQ0WX57.
SMRiQ0WX57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 375USPAdd BLAST296

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiKOG1865. Eukaryota.
ENOG410XQ92. LUCA.
GeneTreeiENSGT00860000133708.
HOVERGENiHBG007129.
InParanoidiQ0WX57.
KOiK11845.
OrthoDBiEOG091G06D5.
PhylomeDBiQ0WX57.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WX57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY
110 120 130 140 150
TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA
160 170 180 190 200
AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY
210 220 230 240 250
WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN
260 270 280 290 300
AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC
310 320 330 340 350
LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM
510 520 530
NTGTLASLRG RARRSKGKNK HSKRALLVCQ
Length:530
Mass (Da):59,711
Last modified:April 29, 2008 - v2
Checksum:i5B0DC65280B2A098
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9R → G in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti9R → G in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti9R → G in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti23S → P in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti262P → S in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti310P → Q in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti310P → Q in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti360T → I in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti361S → P in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti364S → T in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti392R → S in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti398D → A in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti430Q → H in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti511R → G in AAQ11742 (PubMed:17109758).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544011 mRNA. Translation: AAQ11741.1.
AF544012 mRNA. Translation: AAQ11742.1.
AY188990 mRNA. Translation: AAO38845.1.
AC116655 Genomic DNA. No translation available.
RefSeqiNP_001229255.1. NM_001242326.1.
NP_001229256.1. NM_001242327.1.
NP_001229257.1. NM_001242328.1.
NP_001229259.1. NM_001242330.1.
NP_001229260.1. NM_001242331.1.
NP_001229261.1. NM_001242332.1.
NP_001243796.1. NM_001256867.1.
UniGeneiHs.553810.
Hs.631527.
Hs.722783.
Hs.723053.
Hs.741133.

Genome annotation databases

EnsembliENST00000504104; ENSP00000422887; ENSG00000228856.
ENST00000504481; ENSP00000425375; ENSG00000232264.
ENST00000504543; ENSP00000423777; ENSG00000231051.
ENST00000509271; ENSP00000422097; ENSG00000230430.
ENST00000509660; ENSP00000427366; ENSG00000229579.
ENST00000511681; ENSP00000422969; ENSG00000231637.
ENST00000515574; ENSP00000423211; ENSG00000235780.
GeneIDi728369.
728373.
728379.
728393.
728400.
728405.
728419.
KEGGihsa:728369.
hsa:728373.
hsa:728379.
hsa:728393.
hsa:728400.
hsa:728405.
hsa:728419.
UCSCiuc021xll.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544011 mRNA. Translation: AAQ11741.1.
AF544012 mRNA. Translation: AAQ11742.1.
AY188990 mRNA. Translation: AAO38845.1.
AC116655 Genomic DNA. No translation available.
RefSeqiNP_001229255.1. NM_001242326.1.
NP_001229256.1. NM_001242327.1.
NP_001229257.1. NM_001242328.1.
NP_001229259.1. NM_001242330.1.
NP_001229260.1. NM_001242331.1.
NP_001229261.1. NM_001242332.1.
NP_001243796.1. NM_001256867.1.
UniGeneiHs.553810.
Hs.631527.
Hs.722783.
Hs.723053.
Hs.741133.

3D structure databases

ProteinModelPortaliQ0WX57.
SMRiQ0WX57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0WX57. 6 interactors.
STRINGi9606.ENSP00000427366.

Protein family/group databases

MEROPSiC19.023.

PTM databases

iPTMnetiQ0WX57.
PhosphoSitePlusiQ0WX57.

Polymorphism and mutation databases

BioMutaiUSP17L24.
DMDMi187663978.

Proteomic databases

PaxDbiQ0WX57.
PeptideAtlasiQ0WX57.
PRIDEiQ0WX57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504104; ENSP00000422887; ENSG00000228856.
ENST00000504481; ENSP00000425375; ENSG00000232264.
ENST00000504543; ENSP00000423777; ENSG00000231051.
ENST00000509271; ENSP00000422097; ENSG00000230430.
ENST00000509660; ENSP00000427366; ENSG00000229579.
ENST00000511681; ENSP00000422969; ENSG00000231637.
ENST00000515574; ENSP00000423211; ENSG00000235780.
GeneIDi728369.
728373.
728379.
728393.
728400.
728405.
728419.
KEGGihsa:728369.
hsa:728373.
hsa:728379.
hsa:728393.
hsa:728400.
hsa:728405.
hsa:728419.
UCSCiuc021xll.1. human.

Organism-specific databases

CTDi728369.
728373.
728379.
728393.
728400.
728405.
728419.
DisGeNETi728369.
728373.
728379.
728393.
728400.
728405.
728419.
GeneCardsiUSP17L24.
USP17L25.
USP17L26.
USP17L27.
USP17L28.
USP17L29.
USP17L30.
H-InvDBHIX0163954.
HIX0163955.
HGNCiHGNC:44453. USP17L24.
HGNC:44452. USP17L25.
HGNC:44454. USP17L26.
HGNC:44455. USP17L27.
HGNC:44456. USP17L28.
HGNC:44457. USP17L29.
HGNC:44458. USP17L30.
HPAiHPA045642.
MIMi607011. gene.
neXtProtiNX_Q0WX57.
OpenTargetsiENSG00000228856.
ENSG00000229579.
ENSG00000230430.
ENSG00000231051.
ENSG00000231637.
ENSG00000232264.
ENSG00000235780.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1865. Eukaryota.
ENOG410XQ92. LUCA.
GeneTreeiENSGT00860000133708.
HOVERGENiHBG007129.
InParanoidiQ0WX57.
KOiK11845.
OrthoDBiEOG091G06D5.
PhylomeDBiQ0WX57.

Enzyme and pathway databases

BioCyciZFISH:G66-33259-MONOMER.
ReactomeiR-HSA-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiQ0WX57.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ0WX57. differential.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiU17LO_HUMAN
AccessioniPrimary (citable) accession number: Q0WX57
Secondary accession number(s): A8MRA9, Q0WX56, Q3BEM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.