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Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

Gene

USP17L24

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Nucleophile1
Active sitei334Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • hyaluronic acid binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of epithelial cell apoptotic process Source: UniProtKB
  • protein deubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
Gene namesi
Name:USP17L24
Synonyms:USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
AND
AND
AND
AND
AND
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000228856.3
HostDB:ENSG00000229579.4
HostDB:ENSG00000230430.4
HostDB:ENSG00000231051.3
HostDB:ENSG00000231637.3
HostDB:ENSG00000232264.4
HostDB:ENSG00000235780.3
HGNCiHGNC:44453 USP17L24
HGNC:44452 USP17L25
HGNC:44454 USP17L26
HGNC:44455 USP17L27
HGNC:44456 USP17L28
HGNC:44457 USP17L29
HGNC:44458 USP17L30
MIMi607011 gene
neXtProtiNX_Q0WX57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi89C → S: Abolishes enzymatic activity. Loss of the pro-apoptotic function. 2 Publications1

Organism-specific databases

DisGeNETi728369
728373
728379
728393
728400
728405
728419
OpenTargetsiENSG00000228856

Polymorphism and mutation databases

BioMutaiUSP17L24
DMDMi187663978

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316431 – 530Ubiquitin carboxyl-terminal hydrolase 17-like protein 24Add BLAST530

Proteomic databases

PaxDbiQ0WX57
PeptideAtlasiQ0WX57
PRIDEiQ0WX57

PTM databases

iPTMnetiQ0WX57
PhosphoSitePlusiQ0WX57

Expressioni

Tissue specificityi

Expressed in heart, brain, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000229579
ExpressionAtlasiQ0WX57 baseline

Organism-specific databases

HPAiHPA045642

Interactioni

Protein-protein interaction databases

IntActiQ0WX57, 6 interactors
STRINGi9606.ENSP00000427366

Structurei

3D structure databases

ProteinModelPortaliQ0WX57
SMRiQ0WX57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 375USPAdd BLAST296

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOVERGENiHBG007129
InParanoidiQ0WX57
KOiK11845
OMAiDAGEACE
OrthoDBiEOG091G06D5
PhylomeDBiQ0WX57

Family and domain databases

InterProiView protein in InterPro
IPR006861 HABP4_PAIRBP1-bd
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q0WX57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY
110 120 130 140 150
TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA
160 170 180 190 200
AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY
210 220 230 240 250
WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN
260 270 280 290 300
AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC
310 320 330 340 350
LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM
510 520 530
NTGTLASLRG RARRSKGKNK HSKRALLVCQ
Length:530
Mass (Da):59,711
Last modified:April 29, 2008 - v2
Checksum:i5B0DC65280B2A098
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9R → G in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti9R → G in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti9R → G in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti23S → P in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti262P → S in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti310P → Q in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti310P → Q in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti360T → I in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti361S → P in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti364S → T in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti392R → S in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti398D → A in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti430Q → H in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti511R → G in AAQ11742 (PubMed:17109758).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544011 mRNA Translation: AAQ11741.1
AF544012 mRNA Translation: AAQ11742.1
AY188990 mRNA Translation: AAO38845.1
AC116655 Genomic DNA No translation available.
CCDSiCCDS59464.1
RefSeqiNP_001229255.1, NM_001242326.1
NP_001229256.1, NM_001242327.1
NP_001229257.1, NM_001242328.1
NP_001229259.1, NM_001242330.1
NP_001229260.1, NM_001242331.1
NP_001229261.1, NM_001242332.1
NP_001243796.1, NM_001256867.1
UniGeneiHs.553810
Hs.631527
Hs.722783
Hs.723053
Hs.741133

Genome annotation databases

EnsembliENST00000504104; ENSP00000422887; ENSG00000228856
ENST00000504481; ENSP00000425375; ENSG00000232264
ENST00000504543; ENSP00000423777; ENSG00000231051
ENST00000509271; ENSP00000422097; ENSG00000230430
ENST00000509660; ENSP00000427366; ENSG00000229579
ENST00000511681; ENSP00000422969; ENSG00000231637
ENST00000515574; ENSP00000423211; ENSG00000235780
GeneIDi728369
728373
728379
728393
728400
728405
728419
KEGGihsa:728369
hsa:728373
hsa:728379
hsa:728393
hsa:728400
hsa:728405
hsa:728419
UCSCiuc021xll.1 human

Similar proteinsi

Entry informationi

Entry nameiU17LO_HUMAN
AccessioniPrimary (citable) accession number: Q0WX57
Secondary accession number(s): A8MRA9, Q0WX56, Q3BEM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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