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Q0WX57 (U17LO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
Gene names
Name:USP17L24
Synonyms:USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
AND
Name:USP17L25
AND
Name:USP17L26
AND
Name:USP17L27
AND
Name:USP17L28
AND
Name:USP17L29
AND
Name:USP17L30
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Ref.1

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.1 Ref.2

Subcellular location

Nucleusnucleolus. Endoplasmic reticulum By similarity Ref.2.

Tissue specificity

Expressed in heart, brain, liver and skeletal muscle. Ref.1

Sequence similarities

Belongs to the peptidase C19 family. USP17 subfamily.

Contains 1 USP domain.

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.

Ontologies

Keywords
   Biological processApoptosis
Ubl conjugation pathway
   Cellular componentEndoplasmic reticulum
Nucleus
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Ubiquitin carboxyl-terminal hydrolase 17-like protein 24
PRO_0000331643

Regions

Domain80 – 375296USP

Sites

Active site891Nucleophile
Active site3341Proton acceptor By similarity

Experimental info

Mutagenesis891C → S: Abolishes enzymatic activity. Loss of the pro-apoptotic function. Ref.1 Ref.2
Sequence conflict91R → G in AAO38845. Ref.2
Sequence conflict91R → G in AAQ11741. Ref.2
Sequence conflict91R → G in AAQ11742. Ref.2
Sequence conflict231S → P in AAQ11742. Ref.2
Sequence conflict2621P → S in AAQ11741. Ref.2
Sequence conflict3101P → Q in AAQ11741. Ref.2
Sequence conflict3101P → Q in AAQ11742. Ref.2
Sequence conflict3601T → I in AAO38845. Ref.2
Sequence conflict3611S → P in AAQ11742. Ref.2
Sequence conflict3641S → T in AAQ11742. Ref.2
Sequence conflict3921R → S in AAO38845. Ref.2
Sequence conflict3981D → A in AAQ11742. Ref.2
Sequence conflict4301Q → H in AAQ11742. Ref.2
Sequence conflict4921S → T in AAO38845. Ref.2
Sequence conflict4921S → T in AAQ11741. Ref.2
Sequence conflict4921S → T in AAQ11742. Ref.2
Sequence conflict5111R → G in AAQ11742. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q0WX57 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: 5B0DC65280B2A098

FASTA53059,711
        10         20         30         40         50         60 
MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR 

        70         80         90        100        110        120 
QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY TPPLANYMLS REHSQTCHRH 

       130        140        150        160        170        180 
KGCMLCTMQA HITRALHNPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMKKACLPGH 

       190        200        210        220        230        240 
KQVDHHSKDT TLIHQIFGGY WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL 

       250        260        270        280        290        300 
VKPEELNGEN AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC 

       310        320        330        340        350        360 
LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD DAEVTASSIT 

       370        380        390        400        410        420 
SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRATQGELKR DHPCLQAPEL 

       430        440        450        460        470        480 
DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP 

       490        500        510        520        530 
EQQSSLLNLS SSTPTHQESM NTGTLASLRG RARRSKGKNK HSKRALLVCQ 

« Hide

References

« Hide 'large scale' references
[1]"The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter."
Saitoh Y., Miyamoto N., Okada T., Gondo Y., Showguchi-Miyata J., Hadano S., Ikeda J.-E.
Genomics 67:291-300(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-89.
[2]"Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-89.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene."
Okada T., Gondo Y., Goto J., Kanazawa I., Hadano S., Ikeda J.E.
Hum. Genet. 110:302-313(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
Burrows J.F., McGrattan M.J., Johnston J.A.
Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, NOMENCLATURE.
[6]"The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster."
Burrows J.F., Scott C.J., Johnston J.A.
BMC Genomics 11:250-250(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF544011 mRNA. Translation: AAQ11741.1.
AF544012 mRNA. Translation: AAQ11742.1.
AY188990 mRNA. Translation: AAO38845.1.
AC116655 Genomic DNA. No translation available.
RefSeqNP_001229255.1. NM_001242326.1.
NP_001229256.1. NM_001242327.1.
NP_001229257.1. NM_001242328.1.
NP_001229259.1. NM_001242330.1.
NP_001229260.1. NM_001242331.1.
NP_001229261.1. NM_001242332.1.
NP_001243796.1. NM_001256867.1.
UniGeneHs.553810.
Hs.631527.
Hs.722783.
Hs.723053.
Hs.741133.

3D structure databases

ProteinModelPortalQ0WX57.
SMRQ0WX57. Positions 49-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ0WX57. 6 interactions.

Protein family/group databases

MEROPSC19.023.

Polymorphism databases

DMDM187663978.

Proteomic databases

PaxDbQ0WX57.
PRIDEQ0WX57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000504104; ENSP00000422887; ENSG00000228856.
ENST00000504481; ENSP00000425375; ENSG00000232264.
ENST00000504543; ENSP00000423777; ENSG00000231051.
ENST00000509271; ENSP00000422097; ENSG00000230430.
ENST00000509660; ENSP00000427366; ENSG00000229579.
ENST00000511681; ENSP00000422969; ENSG00000231637.
ENST00000515574; ENSP00000423211; ENSG00000235780.
GeneID728369.
728373.
728379.
728393.
728400.
728405.
728419.
KEGGhsa:728369.
hsa:728373.
hsa:728379.
hsa:728393.
hsa:728400.
hsa:728405.
hsa:728419.
UCSCuc021xll.1. human.

Organism-specific databases

CTD728369.
728373.
728379.
728393.
728400.
728405.
728419.
GeneCardsGC04P009327.
GC04P009333.
GC04P009338.
GC04P009347.
GC04P009352.
GC04P009357.
GC04P009372.
H-InvDBHIX0163954.
HIX0163955.
HGNCHGNC:44453. USP17L24.
HGNC:44452. USP17L25.
HGNC:44454. USP17L26.
HGNC:44455. USP17L27.
HGNC:44456. USP17L28.
HGNC:44457. USP17L29.
HGNC:44458. USP17L30.
HPAHPA045642.
MIM607011. gene.
neXtProtNX_Q0WX57.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5533.
HOVERGENHBG007129.
InParanoidQ0WX57.
KOK11845.
OMAQITLDQW.
OrthoDBEOG73NG35.

Gene expression databases

GenevestigatorQ0WX57.

Family and domain databases

InterProIPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio126977.
PROQ0WX57.
SOURCESearch...

Entry information

Entry nameU17LO_HUMAN
AccessionPrimary (citable) accession number: Q0WX57
Secondary accession number(s): A8MRA9, Q0WX56, Q3BEM1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM