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Protein

Ferrochelatase

Gene

At5g26030

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathway: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (At5g26030), Ferrochelatase (At5g26030), Ferrochelatase (FC2), Ferrochelatase-2, chloroplastic (At2g30390)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Heme biosynthesisUniRule annotation, Porphyrin biosynthesisUniRule annotation

Keywords - Ligandi

IronUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:At5g26030Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Organism-specific databases

TAIRiAT5G26030.

PTM / Processingi

Proteomic databases

PRIDEiQ0WW90.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G26030.1.

Structurei

3D structure databases

ProteinModelPortaliQ0WW90.
SMRiQ0WW90. Positions 89-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

KOiK01772.
OMAiVHRSPVL.
PhylomeDBiQ0WW90.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WW90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQATALSSGF NPLTKRKDHR FPRSCSQRNS LSLIQCDIKE RSFGESMTIT
60 70 80 90 100
NRGLSFKTNV FEQARSVTGD CSYDETSAKA RSHVVAEDKI GVLLLNLGGP
110 120 130 140 150
ETLNDVQPFL YNLFADPDII RLPRPFQFLQ GTIAKFISVV RAPKSKEGYA
160 170 180 190 200
AIGGGSPLRK ITDEQADAIK MSLQAKNIAA NVYVGMRYWY PFTEEAVQQI
210 220 230 240 250
KKDKITRLVV LPLYPQYSIS TTGSSIRVLQ DLFRKDPYLA GVPVAIIKSW
260 270 280 290 300
YQRRGYVNSM ADLIEKELQT FSDPKEVMIF FSAHGVPVSY VENAGDPYQK
310 320 330 340 350
QMEECIDLIM EELKARGVLN DHKLAYQSRV GPVQWLKPYT DEVLVDLGKS
360 370 380 390 400
GVKSLLAVPV SFVSEHIETL EEIDMEYREL ALESGVENWG RVPALGLTPS
410 420 430 440 450
FITDLADAVI ESLPSAEAMS NPNAVVDSED SESSDAFSYI VKMFFGSILA
460
FVLLLSPKMF HAFRNL
Length:466
Mass (Da):52,033
Last modified:September 5, 2006 - v1
Checksum:iBAB2F960A5AEBB6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK226466 mRNA. Translation: BAE98608.1.
RefSeqiNP_001031941.1. NM_001036864.1.
NP_197975.3. NM_122504.4.
UniGeneiAt.58.
At.70191.

Genome annotation databases

GeneIDi832672.
KEGGiath:AT5G26030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK226466 mRNA. Translation: BAE98608.1.
RefSeqiNP_001031941.1. NM_001036864.1.
NP_197975.3. NM_122504.4.
UniGeneiAt.58.
At.70191.

3D structure databases

ProteinModelPortaliQ0WW90.
SMRiQ0WW90. Positions 89-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G26030.1.

Proteomic databases

PRIDEiQ0WW90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi832672.
KEGGiath:AT5G26030.

Organism-specific databases

TAIRiAT5G26030.

Phylogenomic databases

KOiK01772.
OMAiVHRSPVL.
PhylomeDBiQ0WW90.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Morosawa T., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K.
    , Akiyama K., Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ0WW90_ARATH
AccessioniPrimary (citable) accession number: Q0WW90
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.