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Protein

Homeobox-leucine zipper protein ANTHOCYANINLESS 2

Gene

ANL2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in the regulation of the tissue-specific accumulation of anthocyanins and in cellular organization of the primary root.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi134 – 193HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • lipid binding Source: InterPro
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • anthocyanin accumulation in tissues in response to UV light Source: TAIR
  • cuticle development Source: TAIR
  • plant-type cell wall modification Source: TAIR
  • root development Source: TAIR
  • root hair cell differentiation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox-leucine zipper protein ANTHOCYANINLESS 2
Alternative name(s):
HD-ZIP protein ANL2
Homeodomain protein AHDP
Homeodomain transcription factor ANL2
Gene namesi
Name:ANL2
Ordered Locus Names:At4g00730
ORF Names:F6N23.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G00730
TAIRilocus:2127008 AT4G00730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Plants display a strong reduction of anthocyanin content on the adaxial side of rosette leaves, a slight reduction onf the abaxial side, and extra cells between cortical and epidermal layers in roots.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316571 – 802Homeobox-leucine zipper protein ANTHOCYANINLESS 2Add BLAST802

Proteomic databases

PaxDbiQ0WV12

PTM databases

iPTMnetiQ0WV12

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and floral buds.1 Publication

Gene expression databases

ExpressionAtlasiQ0WV12 baseline and differential
GenevisibleiQ0WV12 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G00730.1

Structurei

3D structure databases

ProteinModelPortaliQ0WV12
SMRiQ0WV12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 546STARTPROSITE-ProRule annotationAdd BLAST232

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili182 – 221Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 88Poly-Asn4
Compositional biasi90 – 93Poly-Gly4
Compositional biasi297 – 301Poly-Gly5
Compositional biasi306 – 309Poly-Gln4

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Homeobox

Phylogenomic databases

eggNOGiENOG410IIN5 Eukaryota
ENOG411107H LUCA
HOGENOMiHOG000243256
InParanoidiQ0WV12
KOiK09338
OMAiNVKCRRL
OrthoDBiEOG093602MZ
PhylomeDBiQ0WV12

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR002913 START_lipid-bd_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50848 START, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q0WV12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFGSLFDNT PGGGSTGARL LSGLSYGNHT AATNVLPGGA MAQAAAAASL
60 70 80 90 100
FSPPLTKSVY ASSGLSLALE QPERGTNRGE ASMRNNNNVG GGGDTFDGSV
110 120 130 140 150
NRRSREEEHE SRSGSDNVEG ISGEDQDAAD KPPRKKRYHR HTPQQIQELE
160 170 180 190 200
SMFKECPHPD EKQRLELSKR LCLETRQVKF WFQNRRTQMK TQLERHENAL
210 220 230 240 250
LRQENDKLRA ENMSIREAMR NPICTNCGGP AMLGDVSLEE HHLRIENARL
260 270 280 290 300
KDELDRVCNL TGKFLGHHHN HHYNSSLELA VGTNNNGGHF AFPPDFGGGG
310 320 330 340 350
GCLPPQQQQS TVINGIDQKS VLLELALTAM DELVKLAQSE EPLWVKSLDG
360 370 380 390 400
ERDELNQDEY MRTFSSTKPT GLATEASRTS GMVIINSLAL VETLMDSNRW
410 420 430 440 450
TEMFPCNVAR ATTTDVISGG MAGTINGALQ LMNAELQVLS PLVPVRNVNF
460 470 480 490 500
LRFCKQHAEG VWAVVDVSID PVRENSGGAP VIRRLPSGCV VQDVSNGYSK
510 520 530 540 550
VTWVEHAEYD ENQIHQLYRP LLRSGLGFGS QRWLATLQRQ CECLAILISS
560 570 580 590 600
SVTSHDNTSI TPGGRKSMLK LAQRMTFNFC SGISAPSVHN WSKLTVGNVD
610 620 630 640 650
PDVRVMTRKS VDDPGEPPGI VLSAATSVWL PAAPQRLYDF LRNERMRCEW
660 670 680 690 700
DILSNGGPMQ EMAHITKGQD QGVSLLRSNA MNANQSSMLI LQETCIDASG
710 720 730 740 750
ALVVYAPVDI PAMHVVMNGG DSSYVALLPS GFAVLPDGGI DGGGSGDGDQ
760 770 780 790 800
RPVGGGSLLT VAFQILVNNL PTAKLTVESV ETVNNLISCT VQKIRAALQC

ES
Length:802
Mass (Da):87,194
Last modified:September 5, 2006 - v1
Checksum:iC7BADF1697E708A8
GO

Sequence cautioni

The sequence AAB41901 differs from that shown. Reason: Frameshift at position 769.Curated
The sequence AAB41901 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC13617 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80882 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286Missing in AAD47139 (PubMed:10402424).Curated1
Sequence conflicti463A → P in AAD47139 (PubMed:10402424).Curated1
Sequence conflicti548I → M in AAD47139 (PubMed:10402424).Curated1
Sequence conflicti735 – 736LP → SS in AAD47139 (PubMed:10402424).Curated2
Sequence conflicti801E → G in AAD47139 (PubMed:10402424).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85254 mRNA Translation: AAB41901.1 Sequence problems.
AF077335 Genomic DNA Translation: AAD47139.1
AF058919 Genomic DNA Translation: AAC13617.1 Sequence problems.
AL161472 Genomic DNA Translation: CAB80882.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE81926.1
AK226968 mRNA Translation: BAE99036.1
PIRiT01237
RefSeqiNP_567183.2, NM_116298.4 [Q0WV12-1]
UniGeneiAt.24442

Genome annotation databases

EnsemblPlantsiAT4G00730.1; AT4G00730.1; AT4G00730 [Q0WV12-1]
GeneIDi828022
GrameneiAT4G00730.1; AT4G00730.1; AT4G00730 [Q0WV12-1]
KEGGiath:AT4G00730

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANL2_ARATH
AccessioniPrimary (citable) accession number: Q0WV12
Secondary accession number(s): O65281, P93041, Q9SWZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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