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Protein

Homeobox-leucine zipper protein ANTHOCYANINLESS 2

Gene

ANL2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in the regulation of the tissue-specific accumulation of anthocyanins and in cellular organization of the primary root.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi134 – 19360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anthocyanin accumulation in tissues in response to UV light Source: TAIR
  • cuticle development Source: TAIR
  • plant-type cell wall modification Source: TAIR
  • root development Source: TAIR
  • root hair cell differentiation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox-leucine zipper protein ANTHOCYANINLESS 2
Alternative name(s):
HD-ZIP protein ANL2
Homeodomain protein AHDP
Homeodomain transcription factor ANL2
Gene namesi
Name:ANL2
Ordered Locus Names:At4g00730
ORF Names:F6N23.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G00730.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Plants display a strong reduction of anthocyanin content on the adaxial side of rosette leaves, a slight reduction onf the abaxial side, and extra cells between cortical and epidermal layers in roots.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Homeobox-leucine zipper protein ANTHOCYANINLESS 2PRO_0000331657Add
BLAST

Proteomic databases

PaxDbiQ0WV12.
PRIDEiQ0WV12.

PTM databases

iPTMnetiQ0WV12.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and floral buds.1 Publication

Gene expression databases

ExpressionAtlasiQ0WV12. baseline and differential.
GenevisibleiQ0WV12. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G00730.1.

Structurei

3D structure databases

ProteinModelPortaliQ0WV12.
SMRiQ0WV12. Positions 141-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini315 – 546232STARTPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili182 – 22140Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 884Poly-Asn
Compositional biasi90 – 934Poly-Gly
Compositional biasi297 – 3015Poly-Gly
Compositional biasi306 – 3094Poly-Gln

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox

Phylogenomic databases

eggNOGiENOG410IIN5. Eukaryota.
ENOG411107H. LUCA.
HOGENOMiHOG000243256.
InParanoidiQ0WV12.
OMAiCLIARTS.
PhylomeDBiQ0WV12.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q0WV12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFGSLFDNT PGGGSTGARL LSGLSYGNHT AATNVLPGGA MAQAAAAASL
60 70 80 90 100
FSPPLTKSVY ASSGLSLALE QPERGTNRGE ASMRNNNNVG GGGDTFDGSV
110 120 130 140 150
NRRSREEEHE SRSGSDNVEG ISGEDQDAAD KPPRKKRYHR HTPQQIQELE
160 170 180 190 200
SMFKECPHPD EKQRLELSKR LCLETRQVKF WFQNRRTQMK TQLERHENAL
210 220 230 240 250
LRQENDKLRA ENMSIREAMR NPICTNCGGP AMLGDVSLEE HHLRIENARL
260 270 280 290 300
KDELDRVCNL TGKFLGHHHN HHYNSSLELA VGTNNNGGHF AFPPDFGGGG
310 320 330 340 350
GCLPPQQQQS TVINGIDQKS VLLELALTAM DELVKLAQSE EPLWVKSLDG
360 370 380 390 400
ERDELNQDEY MRTFSSTKPT GLATEASRTS GMVIINSLAL VETLMDSNRW
410 420 430 440 450
TEMFPCNVAR ATTTDVISGG MAGTINGALQ LMNAELQVLS PLVPVRNVNF
460 470 480 490 500
LRFCKQHAEG VWAVVDVSID PVRENSGGAP VIRRLPSGCV VQDVSNGYSK
510 520 530 540 550
VTWVEHAEYD ENQIHQLYRP LLRSGLGFGS QRWLATLQRQ CECLAILISS
560 570 580 590 600
SVTSHDNTSI TPGGRKSMLK LAQRMTFNFC SGISAPSVHN WSKLTVGNVD
610 620 630 640 650
PDVRVMTRKS VDDPGEPPGI VLSAATSVWL PAAPQRLYDF LRNERMRCEW
660 670 680 690 700
DILSNGGPMQ EMAHITKGQD QGVSLLRSNA MNANQSSMLI LQETCIDASG
710 720 730 740 750
ALVVYAPVDI PAMHVVMNGG DSSYVALLPS GFAVLPDGGI DGGGSGDGDQ
760 770 780 790 800
RPVGGGSLLT VAFQILVNNL PTAKLTVESV ETVNNLISCT VQKIRAALQC

ES
Length:802
Mass (Da):87,194
Last modified:September 5, 2006 - v1
Checksum:iC7BADF1697E708A8
GO

Sequence cautioni

The sequence AAB41901.1 differs from that shown. Reason: Frameshift at position 769. Curated
The sequence AAB41901.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC13617.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB80882.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861Missing in AAD47139 (PubMed:10402424).Curated
Sequence conflicti463 – 4631A → P in AAD47139 (PubMed:10402424).Curated
Sequence conflicti548 – 5481I → M in AAD47139 (PubMed:10402424).Curated
Sequence conflicti735 – 7362LP → SS in AAD47139 (PubMed:10402424).Curated
Sequence conflicti801 – 8011E → G in AAD47139 (PubMed:10402424).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85254 mRNA. Translation: AAB41901.1. Sequence problems.
AF077335 Genomic DNA. Translation: AAD47139.1.
AF058919 Genomic DNA. Translation: AAC13617.1. Sequence problems.
AL161472 Genomic DNA. Translation: CAB80882.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE81926.1.
AK226968 mRNA. Translation: BAE99036.1.
PIRiT01237.
RefSeqiNP_567183.2. NM_116298.3. [Q0WV12-1]
UniGeneiAt.24442.

Genome annotation databases

EnsemblPlantsiAT4G00730.1; AT4G00730.1; AT4G00730. [Q0WV12-1]
GeneIDi828022.
KEGGiath:AT4G00730.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85254 mRNA. Translation: AAB41901.1. Sequence problems.
AF077335 Genomic DNA. Translation: AAD47139.1.
AF058919 Genomic DNA. Translation: AAC13617.1. Sequence problems.
AL161472 Genomic DNA. Translation: CAB80882.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE81926.1.
AK226968 mRNA. Translation: BAE99036.1.
PIRiT01237.
RefSeqiNP_567183.2. NM_116298.3. [Q0WV12-1]
UniGeneiAt.24442.

3D structure databases

ProteinModelPortaliQ0WV12.
SMRiQ0WV12. Positions 141-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G00730.1.

PTM databases

iPTMnetiQ0WV12.

Proteomic databases

PaxDbiQ0WV12.
PRIDEiQ0WV12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G00730.1; AT4G00730.1; AT4G00730. [Q0WV12-1]
GeneIDi828022.
KEGGiath:AT4G00730.

Organism-specific databases

TAIRiAT4G00730.

Phylogenomic databases

eggNOGiENOG410IIN5. Eukaryota.
ENOG411107H. LUCA.
HOGENOMiHOG000243256.
InParanoidiQ0WV12.
OMAiCLIARTS.
PhylomeDBiQ0WV12.

Miscellaneous databases

PROiQ0WV12.

Gene expression databases

ExpressionAtlasiQ0WV12. baseline and differential.
GenevisibleiQ0WV12. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a meristem L1 layer-specific gene in Arabidopsis that is expressed during embryonic pattern formation and defines a new class of homeobox genes."
    Lu P., Porat R., Nadeau J.A., O'Neill S.D.
    Plant Cell 8:2155-2168(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "ANTHOCYANINLESS2, a homeobox gene affecting anthocyanin distribution and root development in Arabidopsis."
    Kubo H., Peeters A.J.M., Aarts M.G.M., Pereira A., Koornneef M.
    Plant Cell 11:1217-1226(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: cv. Landsberg erecta.
  3. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Organization and structural evolution of four multigene families in Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2."
    Tavares R., Aubourg S., Lecharny A., Kreis M.
    Plant Mol. Biol. 42:703-717(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  7. "Characterization of the class IV homeodomain-leucine zipper gene family in Arabidopsis."
    Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T., Takahashi T.
    Plant Physiol. 141:1363-1375(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiANL2_ARATH
AccessioniPrimary (citable) accession number: Q0WV12
Secondary accession number(s): O65281, P93041, Q9SWZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.