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Protein

BAG family molecular chaperone regulator 1

Gene

BAG1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses.By similarity

GO - Molecular functioni

GO - Biological processi

  • cytoplasm protein quality control by the ubiquitin-proteasome system Source: TAIR

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Alternative name(s):
Bcl-2-associated athanogene 1
Gene namesi
Name:BAG1
Ordered Locus Names:At5g52060
ORF Names:MSG15.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G52060
TAIRilocus:2173108 AT5G52060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004155211 – 342BAG family molecular chaperone regulator 1Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0WUQ1

PTM databases

iPTMnetiQ0WUQ1

Expressioni

Gene expression databases

ExpressionAtlasiQ0WUQ1 baseline and differential
GenevisibleiQ0WUQ1 AT

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP70/HSC70 chaperones.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi20526, 1 interactor
STRINGi3702.AT5G52060.1

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 73Combined sources7
Beta strandi76 – 82Combined sources7
Helixi88 – 99Combined sources12
Helixi103 – 105Combined sources3
Beta strandi106 – 110Combined sources5
Turni121 – 125Combined sources5
Beta strandi130 – 136Combined sources7
Helixi157 – 183Combined sources27
Helixi190 – 207Combined sources18
Helixi214 – 240Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HWCX-ray1.80A/B/C/D/E/F157-241[»]
4HWIX-ray2.27B66-242[»]
ProteinModelPortaliQ0WUQ1
SMRiQ0WUQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 141Ubiquitin-likePROSITE-ProRule annotationAdd BLAST77
Domaini160 – 238BAGPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 46Gly-richAdd BLAST31
Compositional biasi61 – 65Poly-Pro5

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
HOGENOMiHOG000241038
OMAiHNNEERQ
OrthoDBiEOG09360JNK
PhylomeDBiQ0WUQ1

Family and domain databases

Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF02179 BAG, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0WUQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMMRNKPT NLPTAGMTNG GRGSGGGGGG GGRESGGRDL EIRPGGMLVQ
60 70 80 90 100
KRNPDLDPVG PPPPPMIRVR IKYGAVYHEI NISPQASFGE LKKMLTGPTG
110 120 130 140 150
IHHQDQKLMY KDKERDSKAF LDVSGVKDKS KMVLIEDPLS QEKRFLEMRK
160 170 180 190 200
IAKTEKASKA ISDISLEVDR LGGRVSAFEM VTKKGGKIAE KDLVTVIELL
210 220 230 240 250
MNELIKLDAI VAEGDVKLQR KMQVKRVQNY VETLDALKVK NSMANGQQKQ
260 270 280 290 300
SSTAQRLAPI QEHNNEERQE QKPIQSLMDM PIQYKEKKQE IEEEPRNSGE
310 320 330 340
GPFVLDSSAK WETFDHHPVT PLSSTTAKNN AIPPRFNWEF FD
Length:342
Mass (Da):38,191
Last modified:September 5, 2006 - v1
Checksum:iE1F103F7230D55E5
GO

Sequence cautioni

The sequence BAB11054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015478 Genomic DNA Translation: BAB11054.1 Different initiation.
CP002688 Genomic DNA Translation: AED96167.1
AK227095 mRNA Translation: BAE99147.1
BT030041 mRNA Translation: ABN04779.1
RefSeqiNP_200019.2, NM_124585.4
UniGeneiAt.29642

Genome annotation databases

EnsemblPlantsiAT5G52060.1; AT5G52060.1; AT5G52060
GeneIDi835281
GrameneiAT5G52060.1; AT5G52060.1; AT5G52060
KEGGiath:AT5G52060

Similar proteinsi

Entry informationi

Entry nameiBAG1_ARATH
AccessioniPrimary (citable) accession number: Q0WUQ1
Secondary accession number(s): Q9FJ86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: September 5, 2006
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health