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Protein

BAG family molecular chaperone regulator 1

Gene

BAG1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses.By similarity

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Alternative name(s):
Bcl-2-associated athanogene 1
Gene namesi
Name:BAG1
Ordered Locus Names:At5g52060
ORF Names:MSG15.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G52060.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342BAG family molecular chaperone regulator 1PRO_0000415521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei298 – 2981PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0WUQ1.
PRIDEiQ0WUQ1.

PTM databases

iPTMnetiQ0WUQ1.

Expressioni

Gene expression databases

GenevisibleiQ0WUQ1. AT.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP70/HSC70 chaperones.By similarity

Protein-protein interaction databases

BioGridi20526. 1 interaction.
STRINGi3702.AT5G52060.1.

Structurei

Secondary structure

1
342
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 737Combined sources
Beta strandi76 – 827Combined sources
Helixi88 – 9912Combined sources
Helixi103 – 1053Combined sources
Beta strandi106 – 1105Combined sources
Turni121 – 1255Combined sources
Beta strandi130 – 1367Combined sources
Helixi157 – 18327Combined sources
Helixi190 – 20718Combined sources
Helixi214 – 24027Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWCX-ray1.80A/B/C/D/E/F157-241[»]
4HWIX-ray2.27B66-242[»]
ProteinModelPortaliQ0WUQ1.
SMRiQ0WUQ1. Positions 66-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 14177Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini160 – 23879BAGPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 4631Gly-richAdd
BLAST
Compositional biasi61 – 655Poly-Pro

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
HOGENOMiHOG000241038.
OMAiHNNEERQ.
OrthoDBiEOG09360JNK.
PhylomeDBiQ0WUQ1.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WUQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMMRNKPT NLPTAGMTNG GRGSGGGGGG GGRESGGRDL EIRPGGMLVQ
60 70 80 90 100
KRNPDLDPVG PPPPPMIRVR IKYGAVYHEI NISPQASFGE LKKMLTGPTG
110 120 130 140 150
IHHQDQKLMY KDKERDSKAF LDVSGVKDKS KMVLIEDPLS QEKRFLEMRK
160 170 180 190 200
IAKTEKASKA ISDISLEVDR LGGRVSAFEM VTKKGGKIAE KDLVTVIELL
210 220 230 240 250
MNELIKLDAI VAEGDVKLQR KMQVKRVQNY VETLDALKVK NSMANGQQKQ
260 270 280 290 300
SSTAQRLAPI QEHNNEERQE QKPIQSLMDM PIQYKEKKQE IEEEPRNSGE
310 320 330 340
GPFVLDSSAK WETFDHHPVT PLSSTTAKNN AIPPRFNWEF FD
Length:342
Mass (Da):38,191
Last modified:September 5, 2006 - v1
Checksum:iE1F103F7230D55E5
GO

Sequence cautioni

The sequence BAB11054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015478 Genomic DNA. Translation: BAB11054.1. Different initiation.
CP002688 Genomic DNA. Translation: AED96167.1.
AK227095 mRNA. Translation: BAE99147.1.
BT030041 mRNA. Translation: ABN04779.1.
RefSeqiNP_200019.2. NM_124585.3.
UniGeneiAt.29642.

Genome annotation databases

EnsemblPlantsiAT5G52060.1; AT5G52060.1; AT5G52060.
GeneIDi835281.
GrameneiAT5G52060.1; AT5G52060.1; AT5G52060.
KEGGiath:AT5G52060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015478 Genomic DNA. Translation: BAB11054.1. Different initiation.
CP002688 Genomic DNA. Translation: AED96167.1.
AK227095 mRNA. Translation: BAE99147.1.
BT030041 mRNA. Translation: ABN04779.1.
RefSeqiNP_200019.2. NM_124585.3.
UniGeneiAt.29642.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWCX-ray1.80A/B/C/D/E/F157-241[»]
4HWIX-ray2.27B66-242[»]
ProteinModelPortaliQ0WUQ1.
SMRiQ0WUQ1. Positions 66-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20526. 1 interaction.
STRINGi3702.AT5G52060.1.

PTM databases

iPTMnetiQ0WUQ1.

Proteomic databases

PaxDbiQ0WUQ1.
PRIDEiQ0WUQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G52060.1; AT5G52060.1; AT5G52060.
GeneIDi835281.
GrameneiAT5G52060.1; AT5G52060.1; AT5G52060.
KEGGiath:AT5G52060.

Organism-specific databases

TAIRiAT5G52060.

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
HOGENOMiHOG000241038.
OMAiHNNEERQ.
OrthoDBiEOG09360JNK.
PhylomeDBiQ0WUQ1.

Miscellaneous databases

PROiQ0WUQ1.

Gene expression databases

GenevisibleiQ0WUQ1. AT.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAG1_ARATH
AccessioniPrimary (citable) accession number: Q0WUQ1
Secondary accession number(s): Q9FJ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.