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Protein

Presenilin

Gene

At2g29900

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, ProteaseUniRule annotation
Biological processNotch signaling pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
PresenilinUniRule annotation (EC:3.4.23.-UniRule annotation)
Gene namesi
Ordered Locus Names:At2g29900Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 97HelicalUniRule annotationAdd BLAST25
Transmembranei109 – 127HelicalUniRule annotationAdd BLAST19
Transmembranei133 – 155HelicalUniRule annotationAdd BLAST23
Transmembranei162 – 182HelicalUniRule annotationAdd BLAST21
Transmembranei188 – 209HelicalUniRule annotationAdd BLAST22
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21
Transmembranei364 – 383HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Golgi apparatusUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ0WT05.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domaini

The PAL motif is required for normal active site conformation.UniRule annotation

Sequence similaritiesi

Belongs to the peptidase A22A family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2736. Eukaryota.
ENOG410XPZD. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
PANTHERiPTHR10202. PTHR10202. 2 hits.
PfamiView protein in Pfam
PF01080. Presenilin. 1 hit.
PRINTSiPR01072. PRESENILIN.
SMARTiView protein in SMART
SM00730. PSN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0WT05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRNQRPRSI LDSLGEELIA ILTPVSICSF TVVLLVCILN SDPSSSSASF
60 70 80 90 100
SSIATAAYSE SDSDSSWDKF VGALLNSVVF VAAITVATFV LVLLFYLRCV
110 120 130 140 150
KFLKFYMGFS AFIVLGNLGG EILVLLIDRF RFPIDSITFL ILLFNFSVVG
160 170 180 190 200
VFAVFMSKFS ILITQGYLVW IGVLVAYFFT LLPEWTTWVL LVALALYDIA
210 220 230 240 250
AVLLPVGPLR LLVEMAISRD EDIPALVYEA RPVIRNDSRS VQRRVWREQR
260 270 280 290 300
SSQNNANRNE VRVVESAEVE EEHVGSSERA EISVPLIDRR PEQAENSETF
310 320 330 340 350
LEGIGLGSSG AIKLGLGDFI FYSVLVGRAA MYDLMTVYAC YLAIIAGLGI
360 370 380 390
TLMLLSVYQK ALPALPVSIM LGVVFYFLAR LLLEVFVVQC SSNLVMF
Length:397
Mass (Da):43,968
Last modified:September 5, 2006 - v1
Checksum:iDC7561BB79386AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK227760 mRNA. Translation: BAE99743.1.

Similar proteinsi

Entry informationi

Entry nameiQ0WT05_ARATH
AccessioniPrimary (citable) accession number: Q0WT05
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 22, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)