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Protein

Aldehyde dehydrogenase 22A1

Gene

ALDH22A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei199Transition state stabilizerBy similarity1
Active sitei298Proton acceptorPROSITE-ProRule annotation1
Active sitei332NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi276 – 281NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT3G66658-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase 22A1 (EC:1.2.1.3)
Alternative name(s):
Novel aldehyde dehydrogenase family 22 member A1
Gene namesi
Name:ALDH22A1
Ordered Locus Names:At3g66658
ORF Names:T8E24.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G66658
TAIRilocus:2103425 AT3G66658

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000025606931 – 596Aldehyde dehydrogenase 22A1Add BLAST566

Proteomic databases

PaxDbiQ0WSF1

PTM databases

iPTMnetiQ0WSF1

Expressioni

Tissue specificityi

Constituively expressed at low levels.1 Publication

Inductioni

Not induced by abscisic acid (ABA), dehydration and salt stress.1 Publication

Gene expression databases

ExpressionAtlasiQ0WSF1 baseline and differential
GenevisibleiQ0WSF1 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G66658.2

Structurei

3D structure databases

ProteinModelPortaliQ0WSF1
SMRiQ0WSF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2454 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271512
InParanoidiQ0WSF1
OMAiALVSWNY
OrthoDBiEOG093604MP
PhylomeDBiQ0WSF1

Family and domain databases

Gene3Di3.40.309.101 hit
3.40.605.102 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q0WSF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFWWPLIVL AFAYAICKFL LMLIPPNVPS IDVDASDVLA HGKDTEENSF
60 70 80 90 100
IYIPPRGRSQ QSDKKVQCYE PATMKYLGYF PALSPTEVEE RVTLSRKAQK
110 120 130 140 150
TWAQSSFKLR RQFLRILLKY IIEHQELICE VSSRDTGKTM VDASLGEIMT
160 170 180 190 200
TCEKITWLLS EGERWLKPES RSSGRAMLHK VSRVEFHPLG VIGAIVPWNY
210 220 230 240 250
PFHNIFNPML AAVFSGNGIV IKVSEHASWS GCFYFRIIQA ALAAVGAPEN
260 270 280 290 300
LVDVITGFAE TGEALVSSVD KMIFVGSTAV GKMIMRNAAE TLTPVTLELG
310 320 330 340 350
GKDAFIICED ADVSHVAQVA VRGTLQSSGQ NCAGAERFYV HKDIYTAFIG
360 370 380 390 400
QVTKIVKSVS AGPPLTGRYD MGAICLQEHS EHLQSLVNDA LDKGAEIAVR
410 420 430 440 450
GSFGHLGEDA VDQYFPPTVL INVNHNMKIM KEEAFGPIMP IMQFSTDEEV
460 470 480 490 500
IKLANDSRYA LGCAVFSGSK HRAKQIASQI QCGVAAINDF ASNYMCQSLP
510 520 530 540 550
FGGVKDSGFG RFAGIEGLRA CCLVKSVVED RFWPLIKTKI PKPIQYPVAE
560 570 580 590
NAFEFQEALV ETLYGLNIWD RLRSLIDVLK FLTDQSSNVS RTRKSH
Length:596
Mass (Da):66,003
Last modified:October 31, 2006 - v2
Checksum:i25AC39BC26E4C1A8
GO

Sequence cautioni

The sequence AAG50992 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33V → A in BAE99947 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584646 mRNA Translation: CAE48165.1
AC036106 Genomic DNA Translation: AAG50992.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE74433.1
AK227981 mRNA Translation: BAE99947.1
RefSeqiNP_974242.1, NM_202513.3 [Q0WSF1-1]
UniGeneiAt.43176

Genome annotation databases

EnsemblPlantsiAT3G66658.2; AT3G66658.2; AT3G66658 [Q0WSF1-1]
GeneIDi819849
GrameneiAT3G66658.2; AT3G66658.2; AT3G66658 [Q0WSF1-1]
KEGGiath:AT3G66658

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAL221_ARATH
AccessioniPrimary (citable) accession number: Q0WSF1
Secondary accession number(s): Q70E95, Q9C837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 25, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome