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Q0WSF1

- AL221_ARATH

UniProt

Q0WSF1 - AL221_ARATH

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Protein

Aldehyde dehydrogenase 22A1

Gene

ALDH22A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei199 – 1991Transition state stabilizerBy similarity
Active sitei298 – 2981Proton acceptorPROSITE-ProRule annotation
Active sitei332 – 3321NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2816NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT3G66658-MONOMER.
ARA:GQT-2410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase 22A1 (EC:1.2.1.3)
Alternative name(s):
Novel aldehyde dehydrogenase family 22 member A1
Gene namesi
Name:ALDH22A1
Ordered Locus Names:At3g66658
ORF Names:T8E24.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G66658.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. endoplasmic reticulum Source: TAIR
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 596566Aldehyde dehydrogenase 22A1PRO_0000256069Add
BLAST

Proteomic databases

PaxDbiQ0WSF1.
PRIDEiQ0WSF1.

Expressioni

Tissue specificityi

Constituively expressed at low levels.1 Publication

Inductioni

Not induced by abscisic acid (ABA), dehydration and salt stress.1 Publication

Gene expression databases

ExpressionAtlasiQ0WSF1. baseline and differential.
GenevestigatoriQ0WSF1.

Structurei

3D structure databases

ProteinModelPortaliQ0WSF1.
SMRiQ0WSF1. Positions 62-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271512.
InParanoidiQ0WSF1.
OMAiKHITFIG.
PhylomeDBiQ0WSF1.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q0WSF1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFWWPLIVL AFAYAICKFL LMLIPPNVPS IDVDASDVLA HGKDTEENSF
60 70 80 90 100
IYIPPRGRSQ QSDKKVQCYE PATMKYLGYF PALSPTEVEE RVTLSRKAQK
110 120 130 140 150
TWAQSSFKLR RQFLRILLKY IIEHQELICE VSSRDTGKTM VDASLGEIMT
160 170 180 190 200
TCEKITWLLS EGERWLKPES RSSGRAMLHK VSRVEFHPLG VIGAIVPWNY
210 220 230 240 250
PFHNIFNPML AAVFSGNGIV IKVSEHASWS GCFYFRIIQA ALAAVGAPEN
260 270 280 290 300
LVDVITGFAE TGEALVSSVD KMIFVGSTAV GKMIMRNAAE TLTPVTLELG
310 320 330 340 350
GKDAFIICED ADVSHVAQVA VRGTLQSSGQ NCAGAERFYV HKDIYTAFIG
360 370 380 390 400
QVTKIVKSVS AGPPLTGRYD MGAICLQEHS EHLQSLVNDA LDKGAEIAVR
410 420 430 440 450
GSFGHLGEDA VDQYFPPTVL INVNHNMKIM KEEAFGPIMP IMQFSTDEEV
460 470 480 490 500
IKLANDSRYA LGCAVFSGSK HRAKQIASQI QCGVAAINDF ASNYMCQSLP
510 520 530 540 550
FGGVKDSGFG RFAGIEGLRA CCLVKSVVED RFWPLIKTKI PKPIQYPVAE
560 570 580 590
NAFEFQEALV ETLYGLNIWD RLRSLIDVLK FLTDQSSNVS RTRKSH
Length:596
Mass (Da):66,003
Last modified:October 31, 2006 - v2
Checksum:i25AC39BC26E4C1A8
GO

Sequence cautioni

The sequence AAG50992.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331V → A in BAE99947. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584646 mRNA. Translation: CAE48165.1.
AC036106 Genomic DNA. Translation: AAG50992.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE74433.1.
AK227981 mRNA. Translation: BAE99947.1.
RefSeqiNP_974242.1. NM_202513.2. [Q0WSF1-1]
UniGeneiAt.43176.

Genome annotation databases

EnsemblPlantsiAT3G66658.2; AT3G66658.2; AT3G66658. [Q0WSF1-1]
GeneIDi819849.
KEGGiath:AT3G66658.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584646 mRNA. Translation: CAE48165.1 .
AC036106 Genomic DNA. Translation: AAG50992.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE74433.1 .
AK227981 mRNA. Translation: BAE99947.1 .
RefSeqi NP_974242.1. NM_202513.2. [Q0WSF1-1 ]
UniGenei At.43176.

3D structure databases

ProteinModelPortali Q0WSF1.
SMRi Q0WSF1. Positions 62-530.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q0WSF1.
PRIDEi Q0WSF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G66658.2 ; AT3G66658.2 ; AT3G66658 . [Q0WSF1-1 ]
GeneIDi 819849.
KEGGi ath:AT3G66658.

Organism-specific databases

TAIRi AT3G66658.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271512.
InParanoidi Q0WSF1.
OMAi KHITFIG.
PhylomeDBi Q0WSF1.

Enzyme and pathway databases

BioCyci ARA:AT3G66658-MONOMER.
ARA:GQT-2410-MONOMER.

Gene expression databases

ExpressionAtlasi Q0WSF1. baseline and differential.
Genevestigatori Q0WSF1.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Detailed expression analysis of selected genes of the aldehyde dehydrogenase(ALDH) gene superfamily in Arabidopsis thaliana."
    Kirch H.-H., Schlingensiepen S., Kotchoni S., Sunkar R., Bartels D.
    Plant Mol. Biol. 57:315-332(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiAL221_ARATH
AccessioniPrimary (citable) accession number: Q0WSF1
Secondary accession number(s): Q70E95, Q9C837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3