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Q0WSF1

- AL221_ARATH

UniProt

Q0WSF1 - AL221_ARATH

Protein

Aldehyde dehydrogenase 22A1

Gene

ALDH22A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei199 – 1991Transition state stabilizerBy similarity
    Active sitei298 – 2981Proton acceptorPROSITE-ProRule annotation
    Active sitei332 – 3321NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi276 – 2816NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciARA:AT3G66658-MONOMER.
    ARA:GQT-2410-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase 22A1 (EC:1.2.1.3)
    Alternative name(s):
    Novel aldehyde dehydrogenase family 22 member A1
    Gene namesi
    Name:ALDH22A1
    Ordered Locus Names:At3g66658
    ORF Names:T8E24.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G66658.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. endoplasmic reticulum Source: TAIR
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 596566Aldehyde dehydrogenase 22A1PRO_0000256069Add
    BLAST

    Proteomic databases

    PaxDbiQ0WSF1.
    PRIDEiQ0WSF1.

    Expressioni

    Tissue specificityi

    Constituively expressed at low levels.1 Publication

    Inductioni

    Not induced by abscisic acid (ABA), dehydration and salt stress.1 Publication

    Gene expression databases

    GenevestigatoriQ0WSF1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0WSF1.
    SMRiQ0WSF1. Positions 62-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271512.
    InParanoidiQ0WSF1.
    OMAiKHITFIG.
    PhylomeDBiQ0WSF1.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q0WSF1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPFWWPLIVL AFAYAICKFL LMLIPPNVPS IDVDASDVLA HGKDTEENSF    50
    IYIPPRGRSQ QSDKKVQCYE PATMKYLGYF PALSPTEVEE RVTLSRKAQK 100
    TWAQSSFKLR RQFLRILLKY IIEHQELICE VSSRDTGKTM VDASLGEIMT 150
    TCEKITWLLS EGERWLKPES RSSGRAMLHK VSRVEFHPLG VIGAIVPWNY 200
    PFHNIFNPML AAVFSGNGIV IKVSEHASWS GCFYFRIIQA ALAAVGAPEN 250
    LVDVITGFAE TGEALVSSVD KMIFVGSTAV GKMIMRNAAE TLTPVTLELG 300
    GKDAFIICED ADVSHVAQVA VRGTLQSSGQ NCAGAERFYV HKDIYTAFIG 350
    QVTKIVKSVS AGPPLTGRYD MGAICLQEHS EHLQSLVNDA LDKGAEIAVR 400
    GSFGHLGEDA VDQYFPPTVL INVNHNMKIM KEEAFGPIMP IMQFSTDEEV 450
    IKLANDSRYA LGCAVFSGSK HRAKQIASQI QCGVAAINDF ASNYMCQSLP 500
    FGGVKDSGFG RFAGIEGLRA CCLVKSVVED RFWPLIKTKI PKPIQYPVAE 550
    NAFEFQEALV ETLYGLNIWD RLRSLIDVLK FLTDQSSNVS RTRKSH 596
    Length:596
    Mass (Da):66,003
    Last modified:October 31, 2006 - v2
    Checksum:i25AC39BC26E4C1A8
    GO

    Sequence cautioni

    The sequence AAG50992.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331V → A in BAE99947. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ584646 mRNA. Translation: CAE48165.1.
    AC036106 Genomic DNA. Translation: AAG50992.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE74433.1.
    AK227981 mRNA. Translation: BAE99947.1.
    RefSeqiNP_974242.1. NM_202513.2. [Q0WSF1-1]
    UniGeneiAt.43176.

    Genome annotation databases

    EnsemblPlantsiAT3G66658.2; AT3G66658.2; AT3G66658. [Q0WSF1-1]
    GeneIDi819849.
    KEGGiath:AT3G66658.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ584646 mRNA. Translation: CAE48165.1 .
    AC036106 Genomic DNA. Translation: AAG50992.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE74433.1 .
    AK227981 mRNA. Translation: BAE99947.1 .
    RefSeqi NP_974242.1. NM_202513.2. [Q0WSF1-1 ]
    UniGenei At.43176.

    3D structure databases

    ProteinModelPortali Q0WSF1.
    SMRi Q0WSF1. Positions 62-530.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q0WSF1.
    PRIDEi Q0WSF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G66658.2 ; AT3G66658.2 ; AT3G66658 . [Q0WSF1-1 ]
    GeneIDi 819849.
    KEGGi ath:AT3G66658.

    Organism-specific databases

    TAIRi AT3G66658.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271512.
    InParanoidi Q0WSF1.
    OMAi KHITFIG.
    PhylomeDBi Q0WSF1.

    Enzyme and pathway databases

    BioCyci ARA:AT3G66658-MONOMER.
    ARA:GQT-2410-MONOMER.

    Gene expression databases

    Genevestigatori Q0WSF1.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Detailed expression analysis of selected genes of the aldehyde dehydrogenase(ALDH) gene superfamily in Arabidopsis thaliana."
      Kirch H.-H., Schlingensiepen S., Kotchoni S., Sunkar R., Bartels D.
      Plant Mol. Biol. 57:315-332(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiAL221_ARATH
    AccessioniPrimary (citable) accession number: Q0WSF1
    Secondary accession number(s): Q70E95, Q9C837
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3