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Q0WRB2

- P2C73_ARATH

UniProt

Q0WRB2 - P2C73_ARATH

Protein

Probable protein phosphatase 2C 73

Gene

PPC6-7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi97 – 971Manganese 1By similarity
    Metal bindingi97 – 971Manganese 2By similarity
    Metal bindingi98 – 981Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi299 – 2991Manganese 2By similarity
    Metal bindingi345 – 3451Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G27930-MONOMER.
    ARA:GQT-1455-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 73 (EC:3.1.3.16)
    Short name:
    AtPP2C73
    Alternative name(s):
    AtPPC6;7
    Gene namesi
    Name:PPC6-7
    Ordered Locus Names:At5g27930
    ORF Names:F14I23.90, F15F15.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G27930.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Probable protein phosphatase 2C 73PRO_0000367993Add
    BLAST

    Proteomic databases

    PaxDbiQ0WRB2.
    PRIDEiQ0WRB2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ0WRB2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0WRB2.
    SMRiQ0WRB2. Positions 83-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini175 – 333159PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi356 – 3638Poly-Ser

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233897.
    InParanoidiQ0WRB2.
    OMAiCATVDQE.
    PhylomeDBiQ0WRB2.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0WRB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGHFSSMFNG LARSFSIKKV KNNNGNCDAK EAADEMASEA KKKELILKSS    50
    GYVNVQGSNN LASLFSKRGE KGVNQDCALV WEGFGCQEDM IFCGIFDGHG 100
    PWGHYVAKQV RNSMPLSLLC NWQKILAQAT LEPELDLEGS NKKISRFDIW 150
    KQSYLKTCAT VDQELEHHRK IDSYYSGTTA LTIVRQGEVI YVANVGDSRA 200
    VLAMESDEGS LVAVQLTLDF KPNLPQEKER IIGCKGRVFC LDDEPGVHRV 250
    WQPDAETPGL AMSRAFGDYC IKEYGLVSVP EVTQRHISTK DHFIILASDG 300
    IWDVISNQEA IEIVSSTAER PKAAKRLVEQ AVRAWKKKRR GYSMDDMSVV 350
    CLFLHSSSSS SLSQHHHAMT ILK 373
    Length:373
    Mass (Da):41,583
    Last modified:September 5, 2006 - v1
    Checksum:iA062E30C4169A9F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561Q → H in BAC43045. (PubMed:11910074)Curated
    Sequence conflicti144 – 1441I → V in BAC43045. (PubMed:11910074)Curated
    Sequence conflicti242 – 2421D → N in BAB84697. 1 PublicationCurated
    Sequence conflicti328 – 3281V → L in AAM64353. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007627 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED93745.1.
    CP002688 Genomic DNA. Translation: AED93746.1.
    AK118436 mRNA. Translation: BAC43045.1.
    AK229967 mRNA. Translation: BAF01792.1.
    AK228402 mRNA. Translation: BAF00337.1.
    BT026463 mRNA. Translation: ABH04570.1.
    AY086281 mRNA. Translation: AAM64353.1.
    AB079668 mRNA. Translation: BAB84697.1.
    RefSeqiNP_568503.1. NM_122675.3.
    NP_851086.1. NM_180755.1.
    UniGeneiAt.20140.

    Genome annotation databases

    EnsemblPlantsiAT5G27930.1; AT5G27930.1; AT5G27930.
    AT5G27930.2; AT5G27930.2; AT5G27930.
    GeneIDi832860.
    KEGGiath:AT5G27930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007627 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED93745.1 .
    CP002688 Genomic DNA. Translation: AED93746.1 .
    AK118436 mRNA. Translation: BAC43045.1 .
    AK229967 mRNA. Translation: BAF01792.1 .
    AK228402 mRNA. Translation: BAF00337.1 .
    BT026463 mRNA. Translation: ABH04570.1 .
    AY086281 mRNA. Translation: AAM64353.1 .
    AB079668 mRNA. Translation: BAB84697.1 .
    RefSeqi NP_568503.1. NM_122675.3.
    NP_851086.1. NM_180755.1.
    UniGenei At.20140.

    3D structure databases

    ProteinModelPortali Q0WRB2.
    SMRi Q0WRB2. Positions 83-350.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q0WRB2.
    PRIDEi Q0WRB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G27930.1 ; AT5G27930.1 ; AT5G27930 .
    AT5G27930.2 ; AT5G27930.2 ; AT5G27930 .
    GeneIDi 832860.
    KEGGi ath:AT5G27930.

    Organism-specific databases

    TAIRi AT5G27930.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233897.
    InParanoidi Q0WRB2.
    OMAi CATVDQE.
    PhylomeDBi Q0WRB2.

    Enzyme and pathway databases

    BioCyci ARA:AT5G27930-MONOMER.
    ARA:GQT-1455-MONOMER.

    Gene expression databases

    Genevestigatori Q0WRB2.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Arabidopsis ORF Clones."
      Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Substrate specificity of type 2C protein phosphatases (PP2C) in Arabidopsis thaliana."
      Izumi S., Yamada M., Ohsato H., Miyazaki S., Bohnert H.J., Fukuhara T.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-373.
    8. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C73_ARATH
    AccessioniPrimary (citable) accession number: Q0WRB2
    Secondary accession number(s): Q0WM64
    , Q8GX49, Q8LD08, Q8SBC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3