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Protein

1-aminocyclopropane-1-carboxylate oxidase 5

Gene

At1g77330

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme involved in the ethylene biosynthesis.By similarity

Catalytic activityi

1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethylene + cyanide + dehydroascorbate + CO2 + 2 H2O.

Cofactori

Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation

Pathwayi: ethylene biosynthesis via S-adenosyl-L-methionine

This protein is involved in step 2 of the subpathway that synthesizes ethylene from S-adenosyl-L-methionine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1-aminocyclopropane-1-carboxylate synthase 8 (ACS8), 1-aminocyclopropane-1-carboxylate synthase 4 (ACS4), 1-aminocyclopropane-1-carboxylate synthase 2 (ACS2), 1-aminocyclopropane-1-carboxylate synthase 7 (ACS7), 1-aminocyclopropane-1-carboxylate synthase 11 (ACS11), 1-aminocyclopropane-1-carboxylate synthase 9 (ACS9), 1-aminocyclopropane-1-carboxylate synthase 6 (ACS6), 1-aminocyclopropane-1-carboxylate synthase 5 (ACS5)
  2. 1-aminocyclopropane-1-carboxylate oxidase 2 (ACO2), 1-aminocyclopropane-1-carboxylate oxidase 3 (At1g12010), 1-aminocyclopropane-1-carboxylate oxidase 4 (ACO4), 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1), 1-aminocyclopropane-1-carboxylate oxidase 5 (At1g77330)
This subpathway is part of the pathway ethylene biosynthesis via S-adenosyl-L-methionine, which is itself part of Alkene biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ethylene from S-adenosyl-L-methionine, the pathway ethylene biosynthesis via S-adenosyl-L-methionine and in Alkene biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi180 – 1801IronPROSITE-ProRule annotation
Metal bindingi182 – 1821IronPROSITE-ProRule annotation
Metal bindingi237 – 2371IronPROSITE-ProRule annotation
Binding sitei247 – 24712-oxoglutaratePROSITE-ProRule annotation

GO - Molecular functioni

  • 1-aminocyclopropane-1-carboxylate oxidase activity Source: TAIR
  • L-ascorbic acid binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • ethylene biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ethylene biosynthesis, Plant defense

Keywords - Ligandi

Iron, Metal-binding, Vitamin C

Enzyme and pathway databases

BioCyciARA:AT1G77330-MONOMER.
UniPathwayiUPA00384; UER00563.

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate oxidase 5 (EC:1.14.17.4)
Short name:
ACC oxidase 5
Short name:
AtACO5
Gene namesi
Ordered Locus Names:At1g77330
ORF Names:F2P24.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G77330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3073071-aminocyclopropane-1-carboxylate oxidase 5PRO_0000408300Add
BLAST

Proteomic databases

PaxDbiQ0WPW4.
PRIDEiQ0WPW4.

Expressioni

Gene expression databases

GenevisibleiQ0WPW4. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G77330.1.

Structurei

3D structure databases

ProteinModelPortaliQ0WPW4.
SMRiQ0WPW4. Positions 4-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini152 – 256105Fe2OG dioxygenasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili106 – 13429Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 Fe2OG dioxygenase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0143. Eukaryota.
COG3491. LUCA.
HOGENOMiHOG000276735.
InParanoidiQ0WPW4.
KOiK05933.
OMAiGMEEGHI.
PhylomeDBiQ0WPW4.

Family and domain databases

Gene3Di2.60.120.330. 1 hit.
InterProiIPR026992. DIOX_N.
IPR027443. IPNS-like.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
[Graphical view]
PfamiPF03171. 2OG-FeII_Oxy. 1 hit.
PF14226. DIOX_N. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WPW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPVIDFSK LNGEEREKTL SEIARACEEW GFFQLVNHGI PLELLNKVKK
60 70 80 90 100
LSSDCYKTER EEAFKTSNPV KLLNELVQKN SGEKLENVDW EDVFTLLDHN
110 120 130 140 150
QNEWPSNIKE TMGEYREEVR KLASKMMEVM DENLGLPKGY IKKAFNEGME
160 170 180 190 200
DGEETAFFGT KVSHYPPCPH PELVNGLRAH TDAGGVVLLF QDDEYDGLQV
210 220 230 240 250
LKDGEWIDVQ PLPNAIVINT GDQIEVLSNG RYKSAWHRVL AREEGNRRSI
260 270 280 290 300
ASFYNPSYKA AIGPAAVAEE EGSEKKYPKF VFGDYMDVYA NQKFMPKEPR

FLAVKSL
Length:307
Mass (Da):34,947
Last modified:September 5, 2006 - v1
Checksum:iF1B751D7F35E612A
GO

Sequence cautioni

The sequence AAG29196.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071N → K in AAM63764 (Ref. 5) Curated
Sequence conflicti240 – 2401L → V in AAM63764 (Ref. 5) Curated
Sequence conflicti266 – 2661A → T in AAM63764 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078898 Genomic DNA. Translation: AAG29196.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE35965.1.
BT026444 mRNA. Translation: ABH04551.1.
AK228946 mRNA. Translation: BAF00835.1.
AY086710 mRNA. Translation: AAM63764.1.
PIRiC96802.
RefSeqiNP_565154.1. NM_106382.2.
UniGeneiAt.27802.

Genome annotation databases

EnsemblPlantsiAT1G77330.1; AT1G77330.1; AT1G77330.
GeneIDi844069.
GrameneiAT1G77330.1; AT1G77330.1; AT1G77330.
KEGGiath:AT1G77330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078898 Genomic DNA. Translation: AAG29196.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE35965.1.
BT026444 mRNA. Translation: ABH04551.1.
AK228946 mRNA. Translation: BAF00835.1.
AY086710 mRNA. Translation: AAM63764.1.
PIRiC96802.
RefSeqiNP_565154.1. NM_106382.2.
UniGeneiAt.27802.

3D structure databases

ProteinModelPortaliQ0WPW4.
SMRiQ0WPW4. Positions 4-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G77330.1.

Proteomic databases

PaxDbiQ0WPW4.
PRIDEiQ0WPW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G77330.1; AT1G77330.1; AT1G77330.
GeneIDi844069.
GrameneiAT1G77330.1; AT1G77330.1; AT1G77330.
KEGGiath:AT1G77330.

Organism-specific databases

TAIRiAT1G77330.

Phylogenomic databases

eggNOGiKOG0143. Eukaryota.
COG3491. LUCA.
HOGENOMiHOG000276735.
InParanoidiQ0WPW4.
KOiK05933.
OMAiGMEEGHI.
PhylomeDBiQ0WPW4.

Enzyme and pathway databases

UniPathwayiUPA00384; UER00563.
BioCyciARA:AT1G77330-MONOMER.

Miscellaneous databases

PROiQ0WPW4.

Gene expression databases

GenevisibleiQ0WPW4. AT.

Family and domain databases

Gene3Di2.60.120.330. 1 hit.
InterProiIPR026992. DIOX_N.
IPR027443. IPNS-like.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
[Graphical view]
PfamiPF03171. 2OG-FeII_Oxy. 1 hit.
PF14226. DIOX_N. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis ORF Clones."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiACCO5_ARATH
AccessioniPrimary (citable) accession number: Q0WPW4
Secondary accession number(s): Q8LCA2, Q9FVX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 5, 2006
Last modified: February 17, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.