Reviewed,
UniProtKB/Swiss-Prot Q0WM29 (MMSA_ARATH)
Last modified
November 25, 2008.
Version 20.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial Short name=MMSDH Short name=MM-ALDH EC=1.2.1.27 Alternative name(s): Aldehyde dehydrogenase family 6 member B2 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 607 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | 2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH. |
| Subcellular location | MitochondrionPotential. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
| Caution | In contrast to other members of the family, the conserved Glu residue in position 94 is replaced by an Arg. Its activity is therefore unsure. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Coding sequence diversity | Alternative splicing |
| Domain | Transit peptide |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | methylmalonate-semialdehyde dehydrogenase (acylating) activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Notes: A number of isoforms are produced. According to EST sequences. | ||||||
| Isoform 1 (identifier: Q0WM29-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 24 | 24 | Mitochondrion Potential | ||||||
| Chain | 25 – 607 | 583 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial | PRO_0000256067 | |||||
Regions | |||||||||
| Nucleotide binding | 335 – 340 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 391 | 1 | Nucleophile By similarity | ||||||
| Site | 260 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AC007197 Genomic DNA. Translation: AAD25855.1. AK230004 mRNA. Translation: BAF01828.1. | |
| PIR | H84514. |
| RefSeq | NP_179032.1. |
| UniGene | At.43851 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BXS based on UniProtKB P51977. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 815903. |
| GenomeReviews | Gene locus AT2G14170 in contig CT485783_GR. |
| NMPDR | fig|3702.1.peg.8445. |
Organism-specific databases | |
| GeneFarm | 4385. |
| TAIR | At2g14170. |
Family and domain databases | |
| InterPro | IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR010061. MeMal-semiAld_DHase. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF27. MMSDH. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01722. MMSDH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MMSA_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q0WM29 Secondary accession number(s): Q9SI43 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


