ID   NAGK_YERPE              Reviewed;         256 AA.
AC   Q0WGE8; Q74UG3; Q8D0Q4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   05-MAY-2009, entry version 30.
DE   RecName: Full=N-acetyl-D-glucosamine kinase;
DE            EC=2.7.1.59;
DE   AltName: Full=GlcNAc kinase;
GN   Name=nagK; OrderedLocusNames=YPO1629, y1788, YP_1758;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   MEDLINE=21470413; PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA   Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA   Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA   Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   MEDLINE=22137863; PubMed=12142430;
RX   DOI=10.1128/JB.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA   Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA   Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA   Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA   Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA   Yang H., Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetyl-D-glucosamine
CC       (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-
CC       D-glucosamine 6-phosphate.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling.
CC   -!- MISCELLANEOUS: Might be inactive, since the sequence is shorter
CC       than in other family members, due to a probable natural frameshift
CC       in the C-terminus.
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family. NagK subfamily.
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DR   EMBL; AL590842; CAL20274.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85356.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS61985.1; ALT_INIT; Genomic_DNA.
DR   PIR; AH0198; AH0198.
DR   RefSeq; NP_669105.2; -.
DR   RefSeq; NP_993108.2; -.
DR   RefSeq; YP_002346640.1; -.
DR   GeneID; 1146735; -.
DR   GeneID; 1174468; -.
DR   GeneID; 2765632; -.
DR   GenomeReviews; AE009952_GR; y1788.
DR   GenomeReviews; AE017042_GR; YP_1758.
DR   GenomeReviews; AL590842_GR; YPO1629.
DR   KEGG; ype:YPO1629; -.
DR   KEGG; ypk:y1788; -.
DR   KEGG; ypm:YP_1758; -.
DR   HOGENOM; Q0WGE8; -.
DR   OMA; Q0WGE8; CAETYVS.
DR   BioCyc; YPES187410:Y1788-MON; -.
DR   BioCyc; YPES229193:YP1758-MON; -.
DR   BRENDA; 2.7.1.59; 142588.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0045127; F:N-acetylglucosamine kinase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006044; P:N-acetylglucosamine metabolic process; IEA:HAMAP.
DR   GO; GO:0009254; P:peptidoglycan turnover; IEA:HAMAP.
DR   HAMAP; MF_01271; atypical; 1.
DR   InterPro; IPR000600; ROK.
DR   Pfam; PF00480; ROK; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    256       N-acetyl-D-glucosamine kinase.
FT                                /FTId=PRO_0000270125.
FT   NP_BIND       4     11       ATP (Potential).
FT   NP_BIND     133    140       ATP (Potential).
FT   METAL       157    157       Zinc (By similarity).
FT   METAL       177    177       Zinc (By similarity).
FT   METAL       179    179       Zinc (By similarity).
FT   METAL       184    184       Zinc (By similarity).
SQ   SEQUENCE   256 AA;  27879 MW;  0BCE117500ABD548 CRC64;
     MYYGFDMGGT KIELGVFDEN LQRIWHKRVP TPREDYPQLL QILRDLTEEA DTYCGVQGSV
     GIGIPGLPNA DDGTVFTANV PSAMGQPLQA DLSRLIQREV RIDNDANCFA LSEAWDPEFR
     TYPTVLGLIL GTGVGGGLIV NGSIVSGRNH ITGEFGHFRL PVDALDILGA DIPRVPCGCG
     HRGCIENYIS GRGFEWMYSH FYQHTLPATD IIAHYAAGEP KAVAHVERFM DVLAVCLGNL
     LTMLGSPFGR GGWGVV
//