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Q0WGE8

- NAGK_YERPE

UniProt

Q0WGE8 - NAGK_YERPE

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.By similarity

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincBy similarity
    Metal bindingi177 – 1771ZincBy similarity
    Metal bindingi179 – 1791ZincBy similarity
    Metal bindingi184 – 1841ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPSequence Analysis
    Nucleotide bindingi133 – 1408ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. N-acetylglucosamine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidoglycan turnover Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-1610-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
    Alternative name(s):
    GlcNAc kinase
    Gene namesi
    Name:nagK
    Ordered Locus Names:YPO1629, y1788, YP_1758
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256N-acetyl-D-glucosamine kinasePRO_0000270125Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi214092.YPO1629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0WGE8.
    SMRiQ0WGE8. Positions 1-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00884.
    OMAiEMPKRIP.
    OrthoDBiEOG61P6P0.

    Family and domain databases

    InterProiIPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0WGE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDMGGT KIELGVFDEN LQRIWHKRVP TPREDYPQLL QILRDLTEEA    50
    DTYCGVQGSV GIGIPGLPNA DDGTVFTANV PSAMGQPLQA DLSRLIQREV 100
    RIDNDANCFA LSEAWDPEFR TYPTVLGLIL GTGVGGGLIV NGSIVSGRNH 150
    ITGEFGHFRL PVDALDILGA DIPRVPCGCG HRGCIENYIS GRGFEWMYSH 200
    FYQHTLPATD IIAHYAAGEP KAVAHVERFM DVLAVCLGNL LTMLGSPFGR 250
    GGWGVV 256
    Length:256
    Mass (Da):27,879
    Last modified:September 5, 2006 - v1
    Checksum:i0BCE117500ABD548
    GO

    Sequence cautioni

    The sequence AAM85356.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAS61985.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20274.1.
    AE009952 Genomic DNA. Translation: AAM85356.1. Different initiation.
    AE017042 Genomic DNA. Translation: AAS61985.1. Different initiation.
    PIRiAH0198.
    RefSeqiYP_002346640.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM85356; AAM85356; y1788.
    AAS61985; AAS61985; YP_1758.
    GeneIDi1174468.
    KEGGiype:YPO1629.
    PATRICi18592707. VBIYerPes7843_2072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL20274.1 .
    AE009952 Genomic DNA. Translation: AAM85356.1 . Different initiation.
    AE017042 Genomic DNA. Translation: AAS61985.1 . Different initiation.
    PIRi AH0198.
    RefSeqi YP_002346640.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q0WGE8.
    SMRi Q0WGE8. Positions 1-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO1629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM85356 ; AAM85356 ; y1788 .
    AAS61985 ; AAS61985 ; YP_1758 .
    GeneIDi 1174468.
    KEGGi ype:YPO1629.
    PATRICi 18592707. VBIYerPes7843_2072.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00884.
    OMAi EMPKRIP.
    OrthoDBi EOG61P6P0.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci YPES214092:GKDD-1610-MONOMER.

    Family and domain databases

    InterProi IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiNAGK_YERPE
    AccessioniPrimary (citable) accession number: Q0WGE8
    Secondary accession number(s): Q74UG3, Q8D0Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Might be inactive, since the sequence is shorter than in other family members, due to a probable natural frameshift in the C-terminus.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3