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Q0WGE8 (NAGK_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyl-D-glucosamine kinase

EC=2.7.1.59
Alternative name(s):
GlcNAc kinase
Gene names
Name:nagK
Ordered Locus Names:YPO1629, y1788, YP_1758
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity.

Catalytic activity

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Pathway

Cell wall biogenesis; peptidoglycan recycling.

Miscellaneous

Might be inactive, since the sequence is shorter than in other family members, due to a probable natural frameshift in the C-terminus.

Sequence similarities

Belongs to the ROK (NagC/XylR) family. NagK subfamily.

Sequence caution

The sequence AAM85356.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAS61985.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpeptidoglycan turnover

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

N-acetylglucosamine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256N-acetyl-D-glucosamine kinase
PRO_0000270125

Regions

Nucleotide binding4 – 118ATP Potential
Nucleotide binding133 – 1408ATP Potential

Sites

Metal binding1571Zinc By similarity
Metal binding1771Zinc By similarity
Metal binding1791Zinc By similarity
Metal binding1841Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0WGE8 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 0BCE117500ABD548

FASTA25627,879
        10         20         30         40         50         60 
MYYGFDMGGT KIELGVFDEN LQRIWHKRVP TPREDYPQLL QILRDLTEEA DTYCGVQGSV 

        70         80         90        100        110        120 
GIGIPGLPNA DDGTVFTANV PSAMGQPLQA DLSRLIQREV RIDNDANCFA LSEAWDPEFR 

       130        140        150        160        170        180 
TYPTVLGLIL GTGVGGGLIV NGSIVSGRNH ITGEFGHFRL PVDALDILGA DIPRVPCGCG 

       190        200        210        220        230        240 
HRGCIENYIS GRGFEWMYSH FYQHTLPATD IIAHYAAGEP KAVAHVERFM DVLAVCLGNL 

       250 
LTMLGSPFGR GGWGVV 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL20274.1.
AE009952 Genomic DNA. Translation: AAM85356.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61985.1. Different initiation.
PIRAH0198.
RefSeqYP_002346640.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ0WGE8.
SMRQ0WGE8. Positions 1-244.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING214092.YPO1629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM85356; AAM85356; y1788.
AAS61985; AAS61985; YP_1758.
GeneID1174468.
KEGGype:YPO1629.
PATRIC18592707. VBIYerPes7843_2072.

Phylogenomic databases

eggNOGCOG1940.
HOGENOMHOG000150087.
KOK00884.
OMAEMPKRIP.
OrthoDBEOG61P6P0.

Enzyme and pathway databases

BioCycYPES214092:GKDD-1610-MONOMER.
UniPathwayUPA00544.

Family and domain databases

InterProIPR000600. ROK.
[Graphical view]
PfamPF00480. ROK. 1 hit.
[Graphical view]
PROSITEPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGK_YERPE
AccessionPrimary (citable) accession number: Q0WGE8
Secondary accession number(s): Q74UG3, Q8D0Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways