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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.By similarity

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Pathway:ipeptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincBy similarity
Metal bindingi177 – 1771ZincBy similarity
Metal bindingi179 – 1791ZincBy similarity
Metal bindingi184 – 1841ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPSequence Analysis
Nucleotide bindingi133 – 1408ATPSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1610-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagK
Ordered Locus Names:YPO1629, y1788, YP_1758
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000001019 Componenti: Chromosome UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256N-acetyl-D-glucosamine kinasePRO_0000270125Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187410.y1788.

Structurei

3D structure databases

ProteinModelPortaliQ0WGE8.
SMRiQ0WGE8. Positions 1-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.Curated

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiASGHQIV.
OrthoDBiEOG61P6P0.

Family and domain databases

InterProiIPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WGE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYGFDMGGT KIELGVFDEN LQRIWHKRVP TPREDYPQLL QILRDLTEEA
60 70 80 90 100
DTYCGVQGSV GIGIPGLPNA DDGTVFTANV PSAMGQPLQA DLSRLIQREV
110 120 130 140 150
RIDNDANCFA LSEAWDPEFR TYPTVLGLIL GTGVGGGLIV NGSIVSGRNH
160 170 180 190 200
ITGEFGHFRL PVDALDILGA DIPRVPCGCG HRGCIENYIS GRGFEWMYSH
210 220 230 240 250
FYQHTLPATD IIAHYAAGEP KAVAHVERFM DVLAVCLGNL LTMLGSPFGR

GGWGVV
Length:256
Mass (Da):27,879
Last modified:September 5, 2006 - v1
Checksum:i0BCE117500ABD548
GO

Sequence cautioni

The sequence AAM85356.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS61985.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20274.1.
AE009952 Genomic DNA. Translation: AAM85356.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61985.1. Different initiation.
PIRiAH0198.
RefSeqiWP_002216175.1. NZ_KN150725.1.
YP_002346640.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85356; AAM85356; y1788.
AAS61985; AAS61985; YP_1758.
GeneIDi1174468.
KEGGiype:YPO1629.
ypj:CH55_204.
ypl:CH46_3496.
ypv:BZ15_1922.
ypw:CH59_208.
PATRICi18592707. VBIYerPes7843_2072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL20274.1.
AE009952 Genomic DNA. Translation: AAM85356.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61985.1. Different initiation.
PIRiAH0198.
RefSeqiWP_002216175.1. NZ_KN150725.1.
YP_002346640.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ0WGE8.
SMRiQ0WGE8. Positions 1-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187410.y1788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM85356; AAM85356; y1788.
AAS61985; AAS61985; YP_1758.
GeneIDi1174468.
KEGGiype:YPO1629.
ypj:CH55_204.
ypl:CH46_3496.
ypv:BZ15_1922.
ypw:CH59_208.
PATRICi18592707. VBIYerPes7843_2072.

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiASGHQIV.
OrthoDBiEOG61P6P0.

Enzyme and pathway databases

UniPathwayiUPA00544.
BioCyciYPES214092:GKDD-1610-MONOMER.

Family and domain databases

InterProiIPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiNAGK_YERPE
AccessioniPrimary (citable) accession number: Q0WGE8
Secondary accession number(s): Q74UG3, Q8D0Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 5, 2006
Last modified: July 22, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Might be inactive, since the sequence is shorter than in other family members, due to a probable natural frameshift in the C-terminus.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.