Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0WAP4

- PEPQ_YERPE

UniProt

Q0WAP4 - PEPQ_YERPE

Protein

Xaa-Pro dipeptidase

Gene

pepQ

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Splits dipeptides with a prolyl residue in the C-terminal position.UniRule annotation

    Catalytic activityi

    Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi246 – 2461Manganese 2UniRule annotation
    Metal bindingi257 – 2571Manganese 1UniRule annotation
    Metal bindingi257 – 2571Manganese 2UniRule annotation
    Metal bindingi339 – 3391Manganese 1UniRule annotation
    Metal bindingi384 – 3841Manganese 1UniRule annotation
    Metal bindingi423 – 4231Manganese 1UniRule annotation
    Metal bindingi423 – 4231Manganese 2UniRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP
    4. phosphoric triester hydrolase activity Source: InterPro

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-3737-MONOMER.

    Protein family/group databases

    MEROPSiM24.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xaa-Pro dipeptidaseUniRule annotation (EC:3.4.13.9UniRule annotation)
    Short name:
    X-Pro dipeptidaseUniRule annotation
    Alternative name(s):
    ImidodipeptidaseUniRule annotation
    Proline dipeptidaseUniRule annotation
    Short name:
    ProlidaseUniRule annotation
    Gene namesi
    Name:pepQUniRule annotation
    Ordered Locus Names:YPO3765, y0465, YP_3283
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Xaa-Pro dipeptidasePRO_0000303879Add
    BLAST

    Proteomic databases

    PRIDEiQ0WAP4.

    Interactioni

    Protein-protein interaction databases

    IntActiQ0WAP4. 3 interactions.
    STRINGi214092.YPO3765.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0WAP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0006.
    HOGENOMiHOG000290531.
    KOiK01271.
    OMAiMQDDTGT.
    OrthoDBiEOG6XHC3N.

    Family and domain databases

    Gene3Di3.90.230.10. 1 hit.
    HAMAPiMF_01279. X_Pro_dipeptid.
    InterProiIPR000994. Pept_M24_structural-domain.
    IPR001131. Peptidase_M24B_aminopep-P_CS.
    IPR022846. X_Pro_dipept.
    [Graphical view]
    PfamiPF00557. Peptidase_M24. 1 hit.
    [Graphical view]
    SUPFAMiSSF55920. SSF55920. 1 hit.
    PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0WAP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    METLASLYNE HLSTLQQRTR DVLERHQLDA LLIHSGELQR LFLDDRDYPF    50
    KVNPQFKAWV PVTEVPNCWL WVDGVNTPKL WFYSPVDYWH SVEPLPDSFW 100
    TKNIDVQPLL NADDIAQQLP VQRERVAYIG YAQQRAQALG FSAENINPQP 150
    VLDYLHYYRS YKTDYELACM REAQKTAVVG HRAAYEAFQS GMSEFDINLA 200
    YLMATGHRDT DVPYDNIVAL NEHSAVLHYT ILQHQPPAEI RSFLIDAGAE 250
    YNGYAADLTR TYTADRDSDF AALISDLNTE QLALIDTIKS GERYTDYHVQ 300
    MHQRIAKLLR THNLVTGISE EAMVEQGITC PFLPHGLGHP LGLQVHDTAG 350
    FMQDDKGTNL NAPSKYPYLR CTRVLQPRMV LTIEPGLYFI DSLLAPWRIG 400
    EFSKHFNWDR IDALKPYGGI RIEDNIVIHD KRVENMTRDL KLA 443
    Length:443
    Mass (Da):50,912
    Last modified:September 5, 2006 - v1
    Checksum:i63FD90A35262F27E
    GO

    Sequence cautioni

    The sequence AAM84054.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAS63450.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL22352.1.
    AE009952 Genomic DNA. Translation: AAM84054.1. Different initiation.
    AE017042 Genomic DNA. Translation: AAS63450.1. Different initiation.
    PIRiAE0458.
    RefSeqiNP_667803.1. NC_004088.1.
    NP_994573.1. NC_005810.1.
    YP_002348644.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM84054; AAM84054; y0465.
    AAS63450; AAS63450; YP_3283.
    GeneIDi1145412.
    1176600.
    2764609.
    KEGGiype:YPO3765.
    ypk:y0465.
    ypm:YP_3283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. Translation: CAL22352.1 .
    AE009952 Genomic DNA. Translation: AAM84054.1 . Different initiation.
    AE017042 Genomic DNA. Translation: AAS63450.1 . Different initiation.
    PIRi AE0458.
    RefSeqi NP_667803.1. NC_004088.1.
    NP_994573.1. NC_005810.1.
    YP_002348644.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali Q0WAP4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q0WAP4. 3 interactions.
    STRINGi 214092.YPO3765.

    Protein family/group databases

    MEROPSi M24.003.

    Proteomic databases

    PRIDEi Q0WAP4.

    Protocols and materials databases

    DNASUi 1145412.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM84054 ; AAM84054 ; y0465 .
    AAS63450 ; AAS63450 ; YP_3283 .
    GeneIDi 1145412.
    1176600.
    2764609.
    KEGGi ype:YPO3765.
    ypk:y0465.
    ypm:YP_3283.

    Phylogenomic databases

    eggNOGi COG0006.
    HOGENOMi HOG000290531.
    KOi K01271.
    OMAi MQDDTGT.
    OrthoDBi EOG6XHC3N.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-3737-MONOMER.

    Family and domain databases

    Gene3Di 3.90.230.10. 1 hit.
    HAMAPi MF_01279. X_Pro_dipeptid.
    InterProi IPR000994. Pept_M24_structural-domain.
    IPR001131. Peptidase_M24B_aminopep-P_CS.
    IPR022846. X_Pro_dipept.
    [Graphical view ]
    Pfami PF00557. Peptidase_M24. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55920. SSF55920. 1 hit.
    PROSITEi PS00491. PROLINE_PEPTIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiPEPQ_YERPE
    AccessioniPrimary (citable) accession number: Q0WAP4
    Secondary accession number(s): Q74R11, Q8D1H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3