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Protein

Xaa-Pro dipeptidase

Gene

pepQ

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Splits dipeptides with a prolyl residue in the C-terminal position.UniRule annotation

Catalytic activityi

Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi246Manganese 2UniRule annotation1
Metal bindingi257Manganese 1UniRule annotation1
Metal bindingi257Manganese 2UniRule annotation1
Metal bindingi339Manganese 1UniRule annotation1
Metal bindingi384Manganese 1UniRule annotation1
Metal bindingi423Manganese 1UniRule annotation1
Metal bindingi423Manganese 2UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xaa-Pro dipeptidaseUniRule annotation (EC:3.4.13.9UniRule annotation)
Short name:
X-Pro dipeptidaseUniRule annotation
Alternative name(s):
ImidodipeptidaseUniRule annotation
Proline dipeptidaseUniRule annotation
Short name:
ProlidaseUniRule annotation
Gene namesi
Name:pepQUniRule annotation
Ordered Locus Names:YPO3765, y0465, YP_3283
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003038791 – 443Xaa-Pro dipeptidaseAdd BLAST443

Proteomic databases

PaxDbiQ0WAP4

Interactioni

Protein-protein interaction databases

IntActiQ0WAP4, 3 interactors
STRINGi187410.y0465

Structurei

3D structure databases

ProteinModelPortaliQ0WAP4
SMRiQ0WAP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Y Bacteria
COG0006 LUCA
HOGENOMiHOG000290531
KOiK01271
OMAiMQDDTGT

Family and domain databases

Gene3Di3.40.350.10, 1 hit
HAMAPiMF_01279 X_Pro_dipeptid, 1 hit
InterProiView protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001131 Peptidase_M24B_aminopep-P_CS
IPR022846 X_Pro_dipept
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
SUPFAMiSSF55920 SSF55920, 1 hit
PROSITEiView protein in PROSITE
PS00491 PROLINE_PEPTIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0WAP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLASLYNE HLSTLQQRTR DVLERHQLDA LLIHSGELQR LFLDDRDYPF
60 70 80 90 100
KVNPQFKAWV PVTEVPNCWL WVDGVNTPKL WFYSPVDYWH SVEPLPDSFW
110 120 130 140 150
TKNIDVQPLL NADDIAQQLP VQRERVAYIG YAQQRAQALG FSAENINPQP
160 170 180 190 200
VLDYLHYYRS YKTDYELACM REAQKTAVVG HRAAYEAFQS GMSEFDINLA
210 220 230 240 250
YLMATGHRDT DVPYDNIVAL NEHSAVLHYT ILQHQPPAEI RSFLIDAGAE
260 270 280 290 300
YNGYAADLTR TYTADRDSDF AALISDLNTE QLALIDTIKS GERYTDYHVQ
310 320 330 340 350
MHQRIAKLLR THNLVTGISE EAMVEQGITC PFLPHGLGHP LGLQVHDTAG
360 370 380 390 400
FMQDDKGTNL NAPSKYPYLR CTRVLQPRMV LTIEPGLYFI DSLLAPWRIG
410 420 430 440
EFSKHFNWDR IDALKPYGGI RIEDNIVIHD KRVENMTRDL KLA
Length:443
Mass (Da):50,912
Last modified:September 5, 2006 - v1
Checksum:i63FD90A35262F27E
GO

Sequence cautioni

The sequence AAM84054 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS63450 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL22352.1
AE009952 Genomic DNA Translation: AAM84054.1 Different initiation.
AE017042 Genomic DNA Translation: AAS63450.1 Different initiation.
PIRiAE0458
RefSeqiWP_002211547.1, NZ_PDBR01000100.1
YP_002348644.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM84054; AAM84054; y0465
AAS63450; AAS63450; YP_3283
GeneIDi1176600
KEGGiype:YPO3765
ypk:y0465
ypm:YP_3283
PATRICifig|214092.21.peg.4287

Similar proteinsi

Entry informationi

Entry nameiPEPQ_YERPE
AccessioniPrimary (citable) accession number: Q0WAP4
Secondary accession number(s): Q74R11, Q8D1H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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