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Q0WAP4

- PEPQ_YERPE

UniProt

Q0WAP4 - PEPQ_YERPE

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Protein

Xaa-Pro dipeptidase

Gene
pepQ, YPO3765, y0465, YP_3283
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Splits dipeptides with a prolyl residue in the C-terminal position By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.UniRule annotation

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi246 – 2461Manganese 2 By similarity
Metal bindingi257 – 2571Manganese 1 By similarity
Metal bindingi257 – 2571Manganese 2 By similarity
Metal bindingi339 – 3391Manganese 1 By similarity
Metal bindingi384 – 3841Manganese 1 By similarity
Metal bindingi423 – 4231Manganese 1 By similarity
Metal bindingi423 – 4231Manganese 2 By similarity

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
  4. phosphoric triester hydrolase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3737-MONOMER.

Protein family/group databases

MEROPSiM24.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Xaa-Pro dipeptidase (EC:3.4.13.9)
Short name:
X-Pro dipeptidase
Alternative name(s):
Imidodipeptidase
Proline dipeptidase
Short name:
Prolidase
Gene namesi
Name:pepQ
Ordered Locus Names:YPO3765, y0465, YP_3283
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Xaa-Pro dipeptidaseUniRule annotationPRO_0000303879Add
BLAST

Proteomic databases

PRIDEiQ0WAP4.

Interactioni

Protein-protein interaction databases

IntActiQ0WAP4. 3 interactions.
STRINGi214092.YPO3765.

Structurei

3D structure databases

ProteinModelPortaliQ0WAP4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0006.
HOGENOMiHOG000290531.
KOiK01271.
OMAiMQDDTGT.
OrthoDBiEOG6XHC3N.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01279. X_Pro_dipeptid.
InterProiIPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
IPR022846. X_Pro_dipept.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMiSSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WAP4-1 [UniParc]FASTAAdd to Basket

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METLASLYNE HLSTLQQRTR DVLERHQLDA LLIHSGELQR LFLDDRDYPF    50
KVNPQFKAWV PVTEVPNCWL WVDGVNTPKL WFYSPVDYWH SVEPLPDSFW 100
TKNIDVQPLL NADDIAQQLP VQRERVAYIG YAQQRAQALG FSAENINPQP 150
VLDYLHYYRS YKTDYELACM REAQKTAVVG HRAAYEAFQS GMSEFDINLA 200
YLMATGHRDT DVPYDNIVAL NEHSAVLHYT ILQHQPPAEI RSFLIDAGAE 250
YNGYAADLTR TYTADRDSDF AALISDLNTE QLALIDTIKS GERYTDYHVQ 300
MHQRIAKLLR THNLVTGISE EAMVEQGITC PFLPHGLGHP LGLQVHDTAG 350
FMQDDKGTNL NAPSKYPYLR CTRVLQPRMV LTIEPGLYFI DSLLAPWRIG 400
EFSKHFNWDR IDALKPYGGI RIEDNIVIHD KRVENMTRDL KLA 443
Length:443
Mass (Da):50,912
Last modified:September 5, 2006 - v1
Checksum:i63FD90A35262F27E
GO

Sequence cautioni

The sequence AAM84054.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAS63450.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL22352.1.
AE009952 Genomic DNA. Translation: AAM84054.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS63450.1. Different initiation.
PIRiAE0458.
RefSeqiNP_667803.1. NC_004088.1.
NP_994573.1. NC_005810.1.
YP_002348644.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84054; AAM84054; y0465.
AAS63450; AAS63450; YP_3283.
GeneIDi1145412.
1176600.
2764609.
KEGGiype:YPO3765.
ypk:y0465.
ypm:YP_3283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL22352.1 .
AE009952 Genomic DNA. Translation: AAM84054.1 . Different initiation.
AE017042 Genomic DNA. Translation: AAS63450.1 . Different initiation.
PIRi AE0458.
RefSeqi NP_667803.1. NC_004088.1.
NP_994573.1. NC_005810.1.
YP_002348644.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q0WAP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q0WAP4. 3 interactions.
STRINGi 214092.YPO3765.

Protein family/group databases

MEROPSi M24.003.

Proteomic databases

PRIDEi Q0WAP4.

Protocols and materials databases

DNASUi 1145412.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM84054 ; AAM84054 ; y0465 .
AAS63450 ; AAS63450 ; YP_3283 .
GeneIDi 1145412.
1176600.
2764609.
KEGGi ype:YPO3765.
ypk:y0465.
ypm:YP_3283.

Phylogenomic databases

eggNOGi COG0006.
HOGENOMi HOG000290531.
KOi K01271.
OMAi MQDDTGT.
OrthoDBi EOG6XHC3N.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-3737-MONOMER.

Family and domain databases

Gene3Di 3.90.230.10. 1 hit.
HAMAPi MF_01279. X_Pro_dipeptid.
InterProi IPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
IPR022846. X_Pro_dipept.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
SUPFAMi SSF55920. SSF55920. 1 hit.
PROSITEi PS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPEPQ_YERPE
AccessioniPrimary (citable) accession number: Q0WAP4
Secondary accession number(s): Q74R11, Q8D1H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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