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Protein

Xaa-Pro dipeptidase

Gene

pepQ

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Splits dipeptides with a prolyl residue in the C-terminal position.UniRule annotation

Catalytic activityi

Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi246 – 2461Manganese 2UniRule annotation
Metal bindingi257 – 2571Manganese 1UniRule annotation
Metal bindingi257 – 2571Manganese 2UniRule annotation
Metal bindingi339 – 3391Manganese 1UniRule annotation
Metal bindingi384 – 3841Manganese 1UniRule annotation
Metal bindingi423 – 4231Manganese 1UniRule annotation
Metal bindingi423 – 4231Manganese 2UniRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
  4. phosphoric triester hydrolase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xaa-Pro dipeptidaseUniRule annotation (EC:3.4.13.9UniRule annotation)
Short name:
X-Pro dipeptidaseUniRule annotation
Alternative name(s):
ImidodipeptidaseUniRule annotation
Proline dipeptidaseUniRule annotation
Short name:
ProlidaseUniRule annotation
Gene namesi
Name:pepQUniRule annotation
Ordered Locus Names:YPO3765, y0465, YP_3283
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Xaa-Pro dipeptidasePRO_0000303879Add
BLAST

Proteomic databases

PRIDEiQ0WAP4.

Interactioni

Protein-protein interaction databases

IntActiQ0WAP4. 3 interactions.
STRINGi214092.YPO3765.

Structurei

3D structure databases

ProteinModelPortaliQ0WAP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0006.
HOGENOMiHOG000290531.
KOiK01271.
OMAiMQDDTGT.
OrthoDBiEOG6XHC3N.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01279. X_Pro_dipeptid.
InterProiIPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
IPR022846. X_Pro_dipept.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMiSSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0WAP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLASLYNE HLSTLQQRTR DVLERHQLDA LLIHSGELQR LFLDDRDYPF
60 70 80 90 100
KVNPQFKAWV PVTEVPNCWL WVDGVNTPKL WFYSPVDYWH SVEPLPDSFW
110 120 130 140 150
TKNIDVQPLL NADDIAQQLP VQRERVAYIG YAQQRAQALG FSAENINPQP
160 170 180 190 200
VLDYLHYYRS YKTDYELACM REAQKTAVVG HRAAYEAFQS GMSEFDINLA
210 220 230 240 250
YLMATGHRDT DVPYDNIVAL NEHSAVLHYT ILQHQPPAEI RSFLIDAGAE
260 270 280 290 300
YNGYAADLTR TYTADRDSDF AALISDLNTE QLALIDTIKS GERYTDYHVQ
310 320 330 340 350
MHQRIAKLLR THNLVTGISE EAMVEQGITC PFLPHGLGHP LGLQVHDTAG
360 370 380 390 400
FMQDDKGTNL NAPSKYPYLR CTRVLQPRMV LTIEPGLYFI DSLLAPWRIG
410 420 430 440
EFSKHFNWDR IDALKPYGGI RIEDNIVIHD KRVENMTRDL KLA
Length:443
Mass (Da):50,912
Last modified:September 5, 2006 - v1
Checksum:i63FD90A35262F27E
GO

Sequence cautioni

The sequence AAM84054.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS63450.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22352.1.
AE009952 Genomic DNA. Translation: AAM84054.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS63450.1. Different initiation.
PIRiAE0458.
RefSeqiNP_667803.1. NC_004088.1.
NP_994573.1. NC_005810.1.
WP_002211547.1. NZ_KN150726.1.
YP_002348644.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM84054; AAM84054; y0465.
AAS63450; AAS63450; YP_3283.
GeneIDi1145412.
1176600.
2764609.
KEGGiype:YPO3765.
ypk:y0465.
ypm:YP_3283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22352.1.
AE009952 Genomic DNA. Translation: AAM84054.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS63450.1. Different initiation.
PIRiAE0458.
RefSeqiNP_667803.1. NC_004088.1.
NP_994573.1. NC_005810.1.
WP_002211547.1. NZ_KN150726.1.
YP_002348644.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ0WAP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0WAP4. 3 interactions.
STRINGi214092.YPO3765.

Proteomic databases

PRIDEiQ0WAP4.

Protocols and materials databases

DNASUi1145412.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM84054; AAM84054; y0465.
AAS63450; AAS63450; YP_3283.
GeneIDi1145412.
1176600.
2764609.
KEGGiype:YPO3765.
ypk:y0465.
ypm:YP_3283.

Phylogenomic databases

eggNOGiCOG0006.
HOGENOMiHOG000290531.
KOiK01271.
OMAiMQDDTGT.
OrthoDBiEOG6XHC3N.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3737-MONOMER.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01279. X_Pro_dipeptid.
InterProiIPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
IPR022846. X_Pro_dipept.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMiSSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPEPQ_YERPE
AccessioniPrimary (citable) accession number: Q0WAP4
Secondary accession number(s): Q74R11, Q8D1H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.