Q0W932 (ARGC_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	UNCMA_30760
ORF Names:	LRC63

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011080
Sites
	Active site	145	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0W932 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: CC7ECC08DDC1EF6D	FASTA	334	36,714
	10 20 30 40 50 60 MLKIGIVGGT GYTGGELLRL LSIHPLAEVT VVTSRKQAGQ PVDTVHPNLK SLTDLKFEDP 70 80 90 100 110 120 DPAKIAERCD VVFTAVPHGA AMAVVPELLK YGLRVIDLSA DYRLPTEKFE QVYNKKHLDP 130 140 150 160 170 180 REAVYGLPEL HPEVKDATLI ANPGCYPTGA NLACAPLIAQ GLVNRAVVDS KSGISGSGQD 190 200 210 220 230 240 PTEGTHYPNV TQNVRPYNLT THRHKAEIEQ EMLRLNNSTR IHFTPHVIPS TRGIMTTAHL 250 260 270 280 290 300 FVDEPLTTDQ VQTIYDEFYK NKPFVRLQKP SLANVRGSNF CDIAFEVEKD SDRIVVVSAI 310 320 330 DNMVKGASGQ AIQNMNLMYG FDERTGLWTS GLSP

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed: 16857943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ35094.1.
RefSeq	YP_684420.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W932.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0W932.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5144783.
GenomeReviews	Gene locus UNCMA_30760 in contig AM114193_GR.
KEGG	rci:LRC63.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05044.
HOGENOM	HBG294213.
OMA	VCRIAVH.
PhylomeDB	Q0W932.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	UMET351160:LRC63-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_UNCMA

Accession

Primary (citable) accession number: Q0W932

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program