ID   MCH_UNCMA               Reviewed;         318 AA.
AC   Q0W8U9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch; OrderedLocusNames=UNCMA_29790; ORFNames=LRC191;
OS   Uncultured methanogenic archaeon RC-I.
OC   Archaea; Euryarchaeota; environmental samples.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the
RT   rice rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-
CC       H(4)MPT to methenyl-H(4)MPT(+) (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
CC       + H(2)O = 5-formyl-5,6,7,8-tetrahydromethanopterin.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from carbone
CC       dioxide; 5,10-methenyl-H(4)MPT from CO(2): step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the MCH family.
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DR   EMBL; AM114193; CAJ35194.1; -; Genomic_DNA.
DR   RefSeq; YP_684520.1; -.
DR   GeneID; 5143584; -.
DR   GenomeReviews; AM114193_GR; UNCMA_29790.
DR   KEGG; rci:LRC191; -.
DR   OMA; Q0W8U9; YFAMGSG.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrol...; IEA:HAMAP.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   HAMAP; MF_00486; -; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   ProDom; PD011637; Cyclohydrolase; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; Methanogenesis;
KW   One-carbon metabolism.
FT   CHAIN         1    318       Methenyltetrahydromethanopterin
FT                                cyclohydrolase.
FT                                /FTId=PRO_1000014406.
SQ   SEQUENCE   318 AA;  34455 MW;  3659B4B755F87D28 CRC64;
     MISINEISYS IVEEMLDFAE DYRIEPHTLA NDSVVIDCGV KAKAGYEAGL LFTQVCMGGL
     AQTSLTHKKL KHEVFYPFIE VSTDFPAIAC LAAQKAGWRI SQDGYFAMGS GPARALALKP
     KHTYEVIEYE DDYDFAVIAL EADKLPNEKV MDYIASECGV DSSDVVALVA PTNSPVGSVQ
     IAGRVVEMAI YKLAELGFDT RHIVSAFGSA PIPPVKKDAA VAMGTTNDAS IYHGSVTLTV
     DGGNIKDFVP KIPSSTSKDY GKPFYTVFKE AKFDFYKLDP GIFAPAEVVV NDISTGETYI
     AGKINADVCM ESFGFKKL
//