Reviewed, UniProtKB/Swiss-Prot Q0W8U9 (MCH_UNCMA)

Names and origin

Protein names

Recommended name:
    Methenyltetrahydromethanopterin cyclohydrolase
    EC=3.5.4.27
Alternative name(s):
    Methenyl-H4MPT cyclohydrolase

Gene names

Name:	mch
Ordered Locus Names:	UNCMA_29790
ORF Names:	LRC191

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible interconversion of 5-formyl-H4MPT to methenyl-H4MPT+ By similarity.
Catalytic activity	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin. HAMAP MF_00486
Pathway	One-carbon metabolism; methanogenesis from carbone dioxide; 5,10-methenyl-H(4)MPT from CO(2): step 3/3. HAMAP MF_00486
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MCH family.

Ontologies

Keywords
Biological process	Methanogenesis One-carbon metabolism
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methenyltetrahydromethanopterin cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Methenyltetrahydromethanopterin cyclohydrolase HAMAP MF_00486		PRO_1000014406

Sequences

	Sequence		Length	Mass (Da)
	Q0W8U9-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 3659B4B755F87D28	FASTA	318	34,455
	10 20 30 40 50 60 MISINEISYS IVEEMLDFAE DYRIEPHTLA NDSVVIDCGV KAKAGYEAGL LFTQVCMGGL 70 80 90 100 110 120 AQTSLTHKKL KHEVFYPFIE VSTDFPAIAC LAAQKAGWRI SQDGYFAMGS GPARALALKP 130 140 150 160 170 180 KHTYEVIEYE DDYDFAVIAL EADKLPNEKV MDYIASECGV DSSDVVALVA PTNSPVGSVQ 190 200 210 220 230 240 IAGRVVEMAI YKLAELGFDT RHIVSAFGSA PIPPVKKDAA VAMGTTNDAS IYHGSVTLTV 250 260 270 280 290 300 DGGNIKDFVP KIPSSTSKDY GKPFYTVFKE AKFDFYKLDP GIFAPAEVVV NDISTGETYI 310 AGKINADVCM ESFGFKKL

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed: 16857943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM114193 Genomic DNA. Translation: CAJ35194.1.
RefSeq	YP_684520.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5143584.
GenomeReviews	Gene locus UNCMA_29790 in contig AM114193_GR.
KEGG	rci:LRC191.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q0W8U9. YFAMGSG.
Family and domain databases
HAMAP	MF_00486. [Tree]
InterPro	IPR003209. METHMP_CycHdrlase. [Graphical view]
Pfam	PF02289. MCH. 1 hit. [Graphical view]
ProDom	PD011637. Cyclohydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03120. one_C_mch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCH_UNCMA

Accession

Primary (citable) accession number: Q0W8U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)