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Q0W8U9 (MCH_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methenyltetrahydromethanopterin cyclohydrolase
EC=3.5.4.27
Alternative name(s):
Methenyl-H4MPT cyclohydrolase
Gene names
Name:mch
Ordered Locus Names:UNCMA_29790
ORF Names:LRC191
OrganismUncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]
Taxonomic identifier351160 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of 5-formyl-H4MPT to methenyl-H4MPT+ By similarity. HAMAP MF_00486

Catalytic activity

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin. HAMAP MF_00486

Pathway

One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3. HAMAP MF_00486

Subcellular location

Cytoplasm By similarity HAMAP MF_00486.

Sequence similarities

Belongs to the MCH family.

Ontologies

Keywords
   Biological processMethanogenesis
One-carbon metabolism
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmethanogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

one-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmethenyltetrahydromethanopterin cyclohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Methenyltetrahydromethanopterin cyclohydrolase HAMAP MF_00486
PRO_1000014406

Sequences

Sequence LengthMass (Da)Tools
Q0W8U9 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 3659B4B755F87D28

FASTA31834,455
        10         20         30         40         50         60 
MISINEISYS IVEEMLDFAE DYRIEPHTLA NDSVVIDCGV KAKAGYEAGL LFTQVCMGGL 

        70         80         90        100        110        120 
AQTSLTHKKL KHEVFYPFIE VSTDFPAIAC LAAQKAGWRI SQDGYFAMGS GPARALALKP 

       130        140        150        160        170        180 
KHTYEVIEYE DDYDFAVIAL EADKLPNEKV MDYIASECGV DSSDVVALVA PTNSPVGSVQ 

       190        200        210        220        230        240 
IAGRVVEMAI YKLAELGFDT RHIVSAFGSA PIPPVKKDAA VAMGTTNDAS IYHGSVTLTV 

       250        260        270        280        290        300 
DGGNIKDFVP KIPSSTSKDY GKPFYTVFKE AKFDFYKLDP GIFAPAEVVV NDISTGETYI 

       310 
AGKINADVCM ESFGFKKL

« Hide

References

[1]"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
Erkel C., Kube M., Reinhardt R., Liesack W.
Science 313:370-372(2006) [PubMed: 16857943] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM114193 Genomic DNA. Translation: CAJ35194.1.
RefSeqYP_684520.1. NC_009464.1.

3D structure databases

ProteinModelPortalQ0W8U9.
SMRQ0W8U9. Positions 1-315.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0W8U9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5143584.
GenomeReviewsGene locus UNCMA_29790 in contig AM114193_GR.
KEGGrci:LRC191.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG05033.
HOGENOMHBG497176.
OMAYFAMGSG.
ProtClustDBPRK02264.

Enzyme and pathway databases

BioCycUMET351160:LRC191-MONOMER.

Family and domain databases

HAMAPMF_00486. McH.
[Tree]
InterProIPR003209. METHMP_CycHdrlase.
[Graphical view]
KOK01499.
PfamPF02289. MCH. 1 hit.
[Graphical view]
SUPFAMSSF56199. Cyclohydrolase. 1 hit.
TIGRFAMsTIGR03120. One_C_mch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCH_UNCMA
AccessionPrimary (citable) accession number: Q0W8U9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: November 16, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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