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Q0W8L2

- SYE_UNCMA

UniProt

Q0W8L2 - SYE_UNCMA

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUMET351160:GJT4-2973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:UNCMA_28940
ORF Names:LRC306
OrganismiUncultured methanogenic archaeon RC-I
Taxonomic identifieri351160 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
ProteomesiUP000000663: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Glutamate--tRNA ligasePRO_0000367807Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351160.LRC306.

Structurei

3D structure databases

ProteinModelPortaliQ0W8L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi112 – 12211"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiYLGWDDP.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0W8L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METKDIEILI QKFALQNAYK HGSVPQAGAV TGKLLGTHPE LRPHAKELMP
60 70 80 90 100
IVQKVLADIG QMSQDEIKAK LSEIAPELIE ELSVKKEVRR GLPPLDTSML
110 120 130 140 150
KPGQKVTLRI APNPNGPPSL GNARGIIVNH EYARMYDGVF IMRFDDTDPS
160 170 180 190 200
IKKPMIEAYT WYVEHAKWLG CPPDKVVAAS DRLPLYYEQA EKLIDLGKAY
210 220 230 240 250
VCTCDNEVFH DLKEAGKPCP HRETPPAENM EKWKKMLAGG YGGKEAVLRI
260 270 280 290 300
KTDIAHKDPA MRDWVAFRIV TEPHPKTGTK YMVWPMLDFE SAMEDHFLGV
310 320 330 340 350
THIIRGKDLM KTADKQKYIY RYLGWEYPHV SHWGRVRLLG FGKFSTSVMK
360 370 380 390 400
KGIEAGEYRG WDDPQLPTVV ALKRRGIEPE AIRNVMINMG VTETDIEFSM
410 420 430 440 450
DTLYAENRKI VDPKANRYFF VPDPVVLKVN GAPFTTAKAP LHPQDHKRGF
460 470 480 490 500
REMCVAENPE ILIPKSDADN ARPGDILRLK DLYNVRITGS DPLTGDYIGN
510 520 530 540 550
DLSVLKQGAK IVQWVTREGG VPTRVIGPDG EFHGIAECDI RNELNNVVQF
560 570
ERFAFVRIDT INGVVLAYYT HP
Length:572
Mass (Da):64,577
Last modified:September 5, 2006 - v1
Checksum:i286BE9D8D32127DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM114193 Genomic DNA. Translation: CAJ35281.1.
RefSeqiYP_684607.1. NC_009464.1.

Genome annotation databases

EnsemblBacteriaiCAJ35281; CAJ35281; LRC306.
GeneIDi5143841.
KEGGirci:LRC306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM114193 Genomic DNA. Translation: CAJ35281.1 .
RefSeqi YP_684607.1. NC_009464.1.

3D structure databases

ProteinModelPortali Q0W8L2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351160.LRC306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ35281 ; CAJ35281 ; LRC306 .
GeneIDi 5143841.
KEGGi rci:LRC306.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi YLGWDDP.

Enzyme and pathway databases

BioCyci UMET351160:GJT4-2973-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
    Erkel C., Kube M., Reinhardt R., Liesack W.
    Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYE_UNCMA
AccessioniPrimary (citable) accession number: Q0W8L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3