Q0W834 (ILVC_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86

Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	UNCMA_27190
ORF Names:	LRC519

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_1000050589
Sites
	Active site	108	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0W834 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 98B3B2F68276C0DD	FASTA	332	37,000
	10 20 30 40 50 60 MATIYYEKDA DLKILKGKKI AIIGYGSQGM AQSQSLKDSG LDVVVGLRKG GASWEQAKKD 70 80 90 100 110 120 GMKVATIEEA AQQADYIQML IPDELQGKVY HEQIEPYMKK GKILGFSHGF NIHYGMIKPG 130 140 150 160 170 180 KDIDVVMIAP KSPGHLVRRM YQQGAGVPAL VAIQQDASKK ALQYALAYAA GIGCTRAGVL 190 200 210 220 230 240 ATTFKEETET DLFGEQVDLC GGCTEMVKAS FETLVNAGYQ PEIAYFETLH ELKLIVDLMY 250 260 270 280 290 300 EGGMAAMWDS VSDTAQYGGM TRGRRIINEQ SRMEMWRTLE EIQDGRFARE WVLENMAGRP 310 320 330 HFNALTQQDA EHPIEIVGKE LRSMMPWLKQ KK

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed: 16857943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ35459.1.
RefSeq	YP_684785.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W834.
SMR	Q0W834. Positions 3-328.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0W834.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5145121.
GenomeReviews	Gene locus UNCMA_27190 in contig AM114193_GR.
KEGG	rci:LRC519.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04335.
HOGENOM	HBG286525.
OMA	MAYAKGI.
PhylomeDB	Q0W834.
ProtClustDB	PRK05479.
Enzyme and pathway databases
BioCyc	UMET351160:LRC519-MONOMER.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00053.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_UNCMA

Accession

Primary (citable) accession number: Q0W834

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program