Q0W7V3 (HIS3_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	UNCMA_26380
ORF Names:	RCIX21

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000319735

Sequences

	Sequence		Length	Mass (Da)
	Q0W7V3 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 5912ED4B7EC6D05F	FASTA	119	13,773
	10 20 30 40 50 60 MIEPEFKDGL LPVIVQDYET LEVLMFAYMN REAFDLTCST GIAHYFSRSR GKLWKKGETS 70 80 90 100 110 GHYQHVKEMR IDCDRDCLLI LVEQDTGACH TGYRSCFYRT IEGDVVGEKT FEPADVYKN

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed: 16857943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ35540.1.
RefSeq	YP_684866.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W7V3.
SMR	Q0W7V3. Positions 3-113.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0W7V3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5145650.
GenomeReviews	Gene locus UNCMA_26380 in contig AM114193_GR.
KEGG	rci:RCIX21.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12274.
HOGENOM	HBG294308.
OMA	GACHVGY.
ProtClustDB	CLSK2789804.
Enzyme and pathway databases
BioCyc	UMET351160:RCIX21-MONOMER.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
KO	K01496.
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_UNCMA

Accession

Primary (citable) accession number: Q0W7V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 5, 2006
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program