Q0W7S4 (Q0W7S4_UNCMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL CAJ35569.1
Ordered Locus Names:	UNCMA_26090
ORF Names:	RCIX58 EMBL CAJ35569.1

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP] EMBL CAJ35569.1

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length	826 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01897
Ligand	ATP-binding HAMAP MF_01897 DNA-binding HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0W7S4 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 2D880CDF24DDBC15	FASTA	826	91,726
	10 20 30 40 50 60 MADEKQPQPQ SPQQQQTQET LLPVQIEEEM KRSYIDYAMS VIVGRALPDV RDGLKPVHRR 70 80 90 100 110 120 CLYGMYELGN THDKPYKKSA RVVGDVMGKY HPHGDAAIYD TIVRMAQDFS LRYTLVDGQG 130 140 150 160 170 180 NFGSIDGDGA AAMRYTEVRL ERIAEEILAD LDKETVDFAP NFDETLKEPV VLPARLPNLL 190 200 210 220 230 240 INGSSGIAVG MATNIPPHNL GEIVDGTIAV IDNPEIEPIE LLNYVKGPDF PTAGFIYGKE 250 260 270 280 290 300 GIKEAYLTGR GSIRMRAKAE IVDENGKMSI IVTEIPYMVN KARLIESIAD LVKDKKIEGI 310 320 330 340 350 360 SDLRDESDRD GMRIVIELKK AANANVILNQ LFKHTQMEST FGVNNIALVD NTPMTLSLKE 370 380 390 400 410 420 TIGYFIKHRQ EVVTRRSQFE LKKAQAREHI LAGLLIALTN IDDFVRIIRG SANADEAKAT 430 440 450 460 470 480 LMEKYGLSDE QSRAILDMRL ARLTALERQK IDDERADLIK EIAHLNEVLA SPQMVLDIIK 490 500 510 520 530 540 AELLDMKAKY GDERRTKIVE SAGEIVDEDL IPVENVVVTI SNTGYIKRMP VDTYRTQRRG 550 560 570 580 590 600 GVGIVGMETK EEDFVVDLFV ASTHDNILFF SNKGKVYSLK VYEIPPAASR QARGKAIINL 610 620 630 640 650 660 INIEPGEAIN AMIPIKTFDD QHFLVMCTRE GTIKKTALSA FQNIRSTGII AIGLESGDEL 670 680 690 700 710 720 ISVKMTNGSQ EVLIATRNGK CNRFSESEVR TMGRPAMGVI GIRLTENDKV IAMEIVSPGQ 730 740 750 760 770 780 SVLTICENGF GKRTPIEEYT AHHRGGQGMI NIKTTLRNGA VVAVISVMPD DQIVIASKEG 790 800 810 820 MMTRMNVTDI PEIGRNTQGV RVMKMRPEDS VVAVARLVSE KKEDEI

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed: 16857943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ35569.1.
RefSeq	YP_684895.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W7S4.
SMR	Q0W7S4. Positions 43-498.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0W7S4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5143546.
GenomeReviews	Gene locus UNCMA_26090 in contig AM114193_GR.
KEGG	rci:RCIX58.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05278.
HOGENOM	HBG635183.
OMA	TGRGRIY.
PhylomeDB	Q0W7S4.
ProtClustDB	CLSK2789793.
Enzyme and pathway databases
BioCyc	UMET351160:RCIX58-MONOMER.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0W7S4_UNCMA

Accession

Primary (citable) accession number: Q0W7S4

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)