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Q0W7E0

- ASPD_UNCMA

UniProt

Q0W7E0 - ASPD_UNCMA

Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231NAD; via amide nitrogenUniRule annotation
    Binding sitei191 – 1911NADUniRule annotation
    Active sitei221 – 2211UniRule annotation

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP
    4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciUMET351160:GJT4-2542-MONOMER.
    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
    Gene namesi
    Name:nadXUniRule annotation
    Ordered Locus Names:UNCMA_24780
    ORF Names:RCIX226
    OrganismiUncultured methanogenic archaeon RC-I
    Taxonomic identifieri351160 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
    ProteomesiUP000000663: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Probable L-aspartate dehydrogenasePRO_1000067314Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351160.RCIX226.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0W7E0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1712.
    HOGENOMiHOG000206326.
    KOiK06989.
    OMAiECAGHSA.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01265. NadX.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsiTIGR03855. NAD_NadX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0W7E0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRIGIVGAG AIGKEIARAI DNGTVPAKLE AIYDRDTAEA TSFAASLKSK    50
    PRVLPLEELV EASNFVVEAA AQSAVREVAI AALSRSRSVM IMSVGALADK 100
    ELLETIRTMA KEHCCSIYLP SGAIGGLDAV KAASICKIDS VTITTRKPRD 150
    GLRGAPFIVR NNIDVDSMDE PTEIFSGPAA VAIKEFPANV NVAASLSLVG 200
    IGFERTLVRV VVDPTIKRNI HEISVRGEFG ELHTVVENVP ARSNPKTSFL 250
    AALSAIATLR QVCEPLKIGT 270
    Length:270
    Mass (Da):28,621
    Last modified:October 31, 2006 - v1
    Checksum:i62A6113535FAE704
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ35703.1.
    RefSeqiYP_685029.1. NC_009464.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ35703; CAJ35703; RCIX226.
    GeneIDi5143303.
    KEGGirci:RCIX226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ35703.1 .
    RefSeqi YP_685029.1. NC_009464.1.

    3D structure databases

    ProteinModelPortali Q0W7E0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351160.RCIX226.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ35703 ; CAJ35703 ; RCIX226 .
    GeneIDi 5143303.
    KEGGi rci:RCIX226.

    Phylogenomic databases

    eggNOGi COG1712.
    HOGENOMi HOG000206326.
    KOi K06989.
    OMAi ECAGHSA.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .
    BioCyci UMET351160:GJT4-2542-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01265. NadX.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR022487. Asp_DH_arc.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    TIGRFAMsi TIGR03855. NAD_NadX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
      Erkel C., Kube M., Reinhardt R., Liesack W.
      Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiASPD_UNCMA
    AccessioniPrimary (citable) accession number: Q0W7E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3