Q0W6K3 (HIS1_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP phosphoribosyltransferase
Short name=ATP-PRT
Short name=ATP-PRTase
EC=2.4.2.17

Gene names

Name:	hisG
Ordered Locus Names:	UNCMA_21950
ORF Names:	RCIX583

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP MF_00079
Catalytic activity	1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079
Cofactor	Magnesium By similarity. HAMAP MF_00079
Enzyme regulation	Feedback inhibited by histidine By similarity. HAMAP MF_00079
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079
Subcellular location	Cytoplasm By similarity HAMAP MF_00079.
Sequence similarities	Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	ATP phosphoribosyltransferase HAMAP MF_00079		PRO_1000004511

Sequences

	Sequence		Length	Mass (Da)
	Q0W6K3 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 641850CF8C975C34	FASTA	285	30,828
	10 20 30 40 50 60 MVRIALPNKG RVYEPIMSLF EGAGLHVIEH SQRSLFAKTV DENITMLFAR SRDIPGYVEN 70 80 90 100 110 120 GAADLGITGE DFIQEAGADV EVLLDLGMGK AELVLAVPEA SAIERPEQLA GKKVATEFPE 130 140 150 160 170 180 ITKKYFATRG ISVHVVEVCG ATEITPHIGV ADAIVDLTST GTSLSMNRLK IIGRVLRTSQ 190 200 210 220 230 240 RLIASKASLA QDGRKISEIT LALQSVIEAR GKRYLMMNVP EGALEAVKKK LPGLAGPTVL 250 260 270 280 KVEADSPMCA VHAVVPENEI YRVINDLKEV GARDILIVPI ERIVR

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed: 16857943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ35990.1.
RefSeq	YP_685316.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W6K3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0W6K3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5144288.
GenomeReviews	Gene locus UNCMA_21950 in contig AM114193_GR.
KEGG	rci:RCIX583.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04876.
HOGENOM	HBG391868.
OMA	IMLHAPS.
PhylomeDB	Q0W6K3.
ProtClustDB	CLSK2789668.
Enzyme and pathway databases
BioCyc	UMET351160:RCIX583-MONOMER.
Family and domain databases
HAMAP	MF_00079. HisG_Long. [Tree]
InterPro	IPR013820. ATP_PRibTrfase_cat. IPR001348. ATP_PRibTrfase_HisG. IPR020621. ATP_PRibTrfase_HisG_long. IPR013115. HisG_C. IPR011322. N-reg_PII-like_a/b. IPR015867. N-reg_PII/ATP_PRibTrfase_C. [Graphical view]
Gene3D	G3DSA:3.30.70.120. PII_glnB. 1 hit.
KO	K00765.
PANTHER	PTHR21403. ATP_phspho_trans. 1 hit.
Pfam	PF01634. HisG. 1 hit. PF08029. HisG_C. 1 hit. [Graphical view]
SUPFAM	SSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMs	TIGR00070. HisG. 1 hit. TIGR03455. HisG_C-term. 1 hit.
PROSITE	PS01316. ATP_P_PHORIBOSYLTR. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS1_UNCMA

Accession

Primary (citable) accession number: Q0W6K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program