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Q0W5T3

- GSA_UNCMA

UniProt

Q0W5T3 - GSA_UNCMA

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciUMET351160:GJT4-1983-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:UNCMA_19330
    ORF Names:RCIX913
    OrganismiUncultured methanogenic archaeon RC-I
    Taxonomic identifieri351160 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
    ProteomesiUP000000663: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000060004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi351160.RCIX913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0W5T3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0W5T3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQDHSAQLY DEAKSLFPGG VSSPVRAIKP FPFFTKSASG SHITDVDGNE    50
    YIDCCLAYGP LILGHGHPAV KEAITKQLEN GCLYGTPSEI EVKYGKLIQK 100
    YYPGMQKLRF VNTGTEATMG AIRAARGFTG RDKIVKIEGG FHGAHDAVLV 150
    KAGSGATTIG VPDSLGVPVD VVKNTLQVPY NDIHALEETL EAHKDEIACL 200
    IMEPVMGNMG PILPKDMYLR AVRNVTRDYD VLLIFDEVIT GFRVSIFGAQ 250
    GYYGVEPDLT TLGKIAGGGL PIGIFGGRKD IMETVAPQGG VYQAGTYNGN 300
    PLSLTAGMAT VEVLEKESVH HKVNAKGKAL WQSLTDIVRG LRMEGQVTPT 350
    GIASMFQLFF GPQPENYEQA LKCDKLKFNE FWKHMLQNGV FFPPSQFETN 400
    FLSLAHSQAD MEQIVTACKK SLAAVK 426
    Length:426
    Mass (Da):46,294
    Last modified:September 5, 2006 - v1
    Checksum:iCF9D1A4949E84FE3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ36260.1.
    RefSeqiYP_685586.1. NC_009464.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ36260; CAJ36260; RCIX913.
    GeneIDi5145813.
    KEGGirci:RCIX913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ36260.1 .
    RefSeqi YP_685586.1. NC_009464.1.

    3D structure databases

    ProteinModelPortali Q0W5T3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351160.RCIX913.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ36260 ; CAJ36260 ; RCIX913 .
    GeneIDi 5145813.
    KEGGi rci:RCIX913.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci UMET351160:GJT4-1983-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
      Erkel C., Kube M., Reinhardt R., Liesack W.
      Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGSA_UNCMA
    AccessioniPrimary (citable) accession number: Q0W5T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3