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Protein

AMP phosphorylase

Gene

UNCMA_17660

Organism
Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei203AMP; via amide nitrogenUniRule annotation1
Active sitei256Proton donorUniRule annotation1
Binding sitei264AMPUniRule annotation1
Binding sitei288AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 199AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMARV351160:G1GJJ-1802-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:UNCMA_17660
ORF Names:RCIX1126
OrganismiMethanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Taxonomic identifieri351160 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147331 – 503AMP phosphorylaseAdd BLAST503

Proteomic databases

PRIDEiQ0W5A8

Interactioni

Protein-protein interaction databases

STRINGi351160.RCIX1126

Structurei

3D structure databases

ProteinModelPortaliQ0W5A8
SMRiQ0W5A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit

Sequencei

Sequence statusi: Complete.

Q0W5A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRAQPYDI EVGRYEVIIN SADAEELGVL AGDRVQVKDK DTITAVVETT
60 70 80 90 100
DAIVSPGKIG IYREAWESIK VVPDEVVEVL PAAKPKSVSF IRKKMDKQKL
110 120 130 140 150
TSEEMHAIIE DIVDGNLTEV ELTAFVTASY IYTMDSDEIE WMTRAMVKTG
160 170 180 190 200
DQISFDVHPV MDHHSIGGVP GNKISLCIVP IIAAAGLLIP KTSSRAITGA
210 220 230 240 250
GGSADLMEIL CPVSFRADEI KKMTTKVGGC LVWGGATNIA PADDKIINVE
260 270 280 290 300
YPLSIDPKSQ LLASVMAKKF AVGADTMVLD IPCGNETKIP TVQEGRKLAR
310 320 330 340 350
DFMELGDRLG MKIECALTYG GTPLGRAIGG GVEVREAMVM LEKFEGPRSL
360 370 380 390 400
LEKTIAISGM MLEMGGVAPK NEGAKMAVEL VKSGKALQKF KEIIEVQGGD
410 420 430 440 450
PKVTSDMVPI GDKVATVLSP QDGYVLEISN KRLVYMCRLA GAPHDKGVGV
460 470 480 490 500
ILHKKKGEYV KKGDGLFTLY ADKEWKLDAA IKESLRNPIM MVEGMILEKI

EVV
Length:503
Mass (Da):54,495
Last modified:September 5, 2006 - v1
Checksum:iFA8144704978BBBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM114193 Genomic DNA Translation: CAJ36435.1
RefSeqiWP_012036091.1, NC_009464.1

Genome annotation databases

EnsemblBacteriaiCAJ36435; CAJ36435; RCIX1126
GeneIDi5144338
KEGGirci:RCIX1126
PATRICifig|351160.9.peg.1803

Entry informationi

Entry nameiAMPPA_METAR
AccessioniPrimary (citable) accession number: Q0W5A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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