Q0W5A8 (TYPH_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:	UNCMA_17660
ORF Names:	RCIX1126

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanocellales › Methanocellaceae › Methanocella › Methanocella arvoryzae

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314733

Sequences

	Sequence		Length	Mass (Da)
	Q0W5A8 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: FA8144704978BBBC	FASTA	503	54,495
	10 20 30 40 50 60 MKLRAQPYDI EVGRYEVIIN SADAEELGVL AGDRVQVKDK DTITAVVETT DAIVSPGKIG 70 80 90 100 110 120 IYREAWESIK VVPDEVVEVL PAAKPKSVSF IRKKMDKQKL TSEEMHAIIE DIVDGNLTEV 130 140 150 160 170 180 ELTAFVTASY IYTMDSDEIE WMTRAMVKTG DQISFDVHPV MDHHSIGGVP GNKISLCIVP 190 200 210 220 230 240 IIAAAGLLIP KTSSRAITGA GGSADLMEIL CPVSFRADEI KKMTTKVGGC LVWGGATNIA 250 260 270 280 290 300 PADDKIINVE YPLSIDPKSQ LLASVMAKKF AVGADTMVLD IPCGNETKIP TVQEGRKLAR 310 320 330 340 350 360 DFMELGDRLG MKIECALTYG GTPLGRAIGG GVEVREAMVM LEKFEGPRSL LEKTIAISGM 370 380 390 400 410 420 MLEMGGVAPK NEGAKMAVEL VKSGKALQKF KEIIEVQGGD PKVTSDMVPI GDKVATVLSP 430 440 450 460 470 480 QDGYVLEISN KRLVYMCRLA GAPHDKGVGV ILHKKKGEYV KKGDGLFTLY ADKEWKLDAA 490 500 IKESLRNPIM MVEGMILEKI EVV

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ36435.1.
RefSeq	YP_685761.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W5A8.
ModBase	Search...
Protein-protein interaction databases
STRING	351160.RCIX1126.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ36435; CAJ36435; RCIX1126.
GeneID	5144338.
KEGG	rci:RCIX1126.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Family and domain databases
Gene3D	2.40.40.20. 1 hit. 3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR009010. Asp_de-COase-like_dom. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_UNCMA

Accession

Primary (citable) accession number: Q0W5A8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program