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Q0W5A8

- AMPPA_UNCMA

UniProt

Q0W5A8 - AMPPA_UNCMA

Protein

AMP phosphorylase

Gene

UNCMA_17660

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei168 – 1681AMP; via amide nitrogenUniRule annotation
    Binding sitei203 – 2031AMP; via amide nitrogenUniRule annotation
    Active sitei256 – 2561Proton donorUniRule annotation
    Binding sitei264 – 2641AMPUniRule annotation
    Binding sitei288 – 2881AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi194 – 1996AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciUMET351160:GJT4-1811-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpaseUniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylaseUniRule annotation
    Short name:
    NMP phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:UNCMA_17660
    ORF Names:RCIX1126
    OrganismiUncultured methanogenic archaeon RC-I
    Taxonomic identifieri351160 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
    ProteomesiUP000000663: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503AMP phosphorylasePRO_0000314733Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351160.RCIX1126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0W5A8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiESVPGFH.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0W5A8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLRAQPYDI EVGRYEVIIN SADAEELGVL AGDRVQVKDK DTITAVVETT    50
    DAIVSPGKIG IYREAWESIK VVPDEVVEVL PAAKPKSVSF IRKKMDKQKL 100
    TSEEMHAIIE DIVDGNLTEV ELTAFVTASY IYTMDSDEIE WMTRAMVKTG 150
    DQISFDVHPV MDHHSIGGVP GNKISLCIVP IIAAAGLLIP KTSSRAITGA 200
    GGSADLMEIL CPVSFRADEI KKMTTKVGGC LVWGGATNIA PADDKIINVE 250
    YPLSIDPKSQ LLASVMAKKF AVGADTMVLD IPCGNETKIP TVQEGRKLAR 300
    DFMELGDRLG MKIECALTYG GTPLGRAIGG GVEVREAMVM LEKFEGPRSL 350
    LEKTIAISGM MLEMGGVAPK NEGAKMAVEL VKSGKALQKF KEIIEVQGGD 400
    PKVTSDMVPI GDKVATVLSP QDGYVLEISN KRLVYMCRLA GAPHDKGVGV 450
    ILHKKKGEYV KKGDGLFTLY ADKEWKLDAA IKESLRNPIM MVEGMILEKI 500
    EVV 503
    Length:503
    Mass (Da):54,495
    Last modified:September 5, 2006 - v1
    Checksum:iFA8144704978BBBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ36435.1.
    RefSeqiYP_685761.1. NC_009464.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ36435; CAJ36435; RCIX1126.
    GeneIDi5144338.
    KEGGirci:RCIX1126.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ36435.1 .
    RefSeqi YP_685761.1. NC_009464.1.

    3D structure databases

    ProteinModelPortali Q0W5A8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351160.RCIX1126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ36435 ; CAJ36435 ; RCIX1126 .
    GeneIDi 5144338.
    KEGGi rci:RCIX1126.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi ESVPGFH.

    Enzyme and pathway databases

    BioCyci UMET351160:GJT4-1811-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
      Erkel C., Kube M., Reinhardt R., Liesack W.
      Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiAMPPA_UNCMA
    AccessioniPrimary (citable) accession number: Q0W5A8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3