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Q0W4M8 (G1PDH_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol-1-phosphate dehydrogenase [NAD(P)+]
Short name=G1P dehydrogenase
Short name=G1PDH
EC=1.1.1.261
Alternative name(s):
Enantiomeric glycerophosphate synthase
sn-glycerol-1-phosphate dehydrogenase
Gene names
Name:egsA
Ordered Locus Names:UNCMA_15600
ORF Names:RCIX1388
OrganismUncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]
Taxonomic identifier351160 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol-1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea By similarity. HAMAP MF_00497_A

Catalytic activity

sn-glycerol-1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP MF_00497_A

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00497_A

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP MF_00497_A

Subcellular location

Cytoplasm Potential HAMAP MF_00497_A.

Sequence similarities

Belongs to the glycerol-1-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
NADP
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglycerol-1-phosphate dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Glycerol-1-phosphate dehydrogenase [NAD(P)+] HAMAP MF_00497_A
PRO_0000350664

Regions

Nucleotide binding91 – 955NAD By similarity
Nucleotide binding113 – 1164NAD By similarity

Sites

Metal binding1651Zinc; catalytic By similarity
Metal binding2451Zinc; catalytic By similarity
Metal binding2611Zinc; catalytic By similarity
Binding site1181Substrate By similarity
Binding site1221NAD By similarity
Binding site1651Substrate By similarity
Binding site2491Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0W4M8 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 12081D6A83A18CC1

FASTA34536,768
        10         20         30         40         50         60 
MQLPRNVIAG PGAIRSVGDL CRSMRLKGRG LIVTGKTTKQ IAGDIVADSL REAGYGADFL 

        70         80         90        100        110        120 
LVENATMENV EKAEALAREL KAEFLLGVGG GKSIDIAKIA STRLNMYYLS IPTAASHDGI 

       130        140        150        160        170        180 
ASSRASIRHD GETVSMQAEA PLCVLADTSI IVRSPYKLLA AGCGDVISNY TAVLDWKLAS 

       190        200        210        220        230        240 
RLRNIYFSEY AAALSQMTAE IVVNSAHMIR PGLEESAQEV VKALVSSSVA MSIAGSSAPA 

       250        260        270        280        290        300 
SGSEHKFSHV LDRIAPKPAL HGEQCGVGTI LMMYLHGGDW EKIRDALNTI GAPVTAREMG 

       310        320        330        340 
IEDKYILQAM TEAHKIRPER YTILGDTGIT LEAAEKVARA TGVIE

« Hide

References

[1]"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
Erkel C., Kube M., Reinhardt R., Liesack W.
Science 313:370-372(2006) [PubMed: 16857943] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM114193 Genomic DNA. Translation: CAJ36665.1.
RefSeqYP_685991.1. NC_009464.1.

3D structure databases

ProteinModelPortalQ0W4M8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0W4M8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5145747.
GenomeReviewsGene locus UNCMA_15600 in contig AM114193_GR.
KEGGrci:RCIX1388.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04488.
HOGENOMHBG672951.
OMACGVGTIM.
PhylomeDBQ0W4M8.
ProtClustDBPRK00843.

Enzyme and pathway databases

BioCycUMET351160:RCIX1388-MONOMER.

Family and domain databases

HAMAPMF_00497_A. G1P_dehydrogenase_A.
[Tree]
InterProIPR023002. G1P_dehydrogenase_arc.
IPR016205. Glycerol_DH.
[Graphical view]
KOK00096.
PIRSFPIRSF000112. Glycerol_dehydrogenase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG1PDH_UNCMA
AccessionPrimary (citable) accession number: Q0W4M8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 5, 2006
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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