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Q0W498 (MFNA_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-tyrosine decarboxylase

Short name=TDC
EC=4.1.1.25
Gene names
Name:mfnA
Ordered Locus Names:UNCMA_14340
ORF Names:RCIX1543
OrganismUncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]
Taxonomic identifier351160 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine By similarity. HAMAP-Rule MF_01610

Catalytic activity

L-tyrosine = tyramine + CO2. HAMAP-Rule MF_01610

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01610

Pathway

Cofactor biosynthesis; methanofuran biosynthesis. HAMAP-Rule MF_01610

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01610

Sequence similarities

Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcoenzyme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375L-tyrosine decarboxylase HAMAP-Rule MF_01610
PRO_0000293191

Amino acid modifications

Modified residue2261N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0W498 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: E8990460A4847961

FASTA37541,138
        10         20         30         40         50         60 
MRERGLGEEE IFAELCEARS RDVPYGRVLS SMCTNPHPIA VKAHQEFVNT NLGDPKLFPG 

        70         80         90        100        110        120 
TADIEHRCIG LIGDLLHLPA ATGYISTGGT ESNIQALRTA IQMKHTDRRR ANIVVPESAH 

       130        140        150        160        170        180 
YSFEKASQML GIAIRRAPLD DLLRADPSEM AALIDKNTIA LVAVAGTTEF GQIDPIEEIG 

       190        200        210        220        230        240 
RLAQEHDLYL HVDAAFGGFV IPFMDRPAKF DFEIPGVQSI TIDPHKMGLS TIPSGGLLYR 

       250        260        270        280        290        300 
SESLMKVLEI NAQYLTSMVQ TSLAGTRSGA SAASAYAVLQ YLGRAGYREI VATCMENTRI 

       310        320        330        340        350        360 
LREQLEDMGM EPIIEPVLNI VTARAKDPVG LRKKLAEKNW YVSTTVHPCA LRMVVMPHVT 

       370 
ADVIEAFTAD LKKVI 

« Hide

References

[1]"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
Erkel C., Kube M., Reinhardt R., Liesack W.
Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM114193 Genomic DNA. Translation: CAJ36795.1.
RefSeqYP_686121.1. NC_009464.1.

3D structure databases

ProteinModelPortalQ0W498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351160.RCIX1543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ36795; CAJ36795; RCIX1543.
GeneID5142888.
KEGGrci:RCIX1543.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000246269.
KOK01592.
OMADPGLFKG.
ProtClustDBPRK13520.

Enzyme and pathway databases

BioCycUMET351160:GJT4-1471-MONOMER.
UniPathwayUPA00080.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_01610. Tyr_decarbox.
InterProIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR03812. tyr_de_CO2_Arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMFNA_UNCMA
AccessionPrimary (citable) accession number: Q0W498
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways