Q0W498 (MFNA_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-tyrosine decarboxylase
Short name=TDC
EC=4.1.1.25

Gene names

Name:	mfnA
Ordered Locus Names:	UNCMA_14340
ORF Names:	RCIX1543

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanocellales › Methanocellaceae › Methanocella › Methanocella arvoryzae

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine By similarity. HAMAP-Rule MF_01610
Catalytic activity	L-tyrosine = tyramine + CO2. HAMAP-Rule MF_01610
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Cofactor biosynthesis; methanofuran biosynthesis. HAMAP-Rule MF_01610
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme biosynthetic process Inferred from electronic annotation. Source: HAMAP tyrosine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP tyrosine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	L-tyrosine decarboxylase HAMAP-Rule MF_01610		PRO_0000293191
Amino acid modifications
	Modified residue	226	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0W498 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: E8990460A4847961	FASTA	375	41,138
	10 20 30 40 50 60 MRERGLGEEE IFAELCEARS RDVPYGRVLS SMCTNPHPIA VKAHQEFVNT NLGDPKLFPG 70 80 90 100 110 120 TADIEHRCIG LIGDLLHLPA ATGYISTGGT ESNIQALRTA IQMKHTDRRR ANIVVPESAH 130 140 150 160 170 180 YSFEKASQML GIAIRRAPLD DLLRADPSEM AALIDKNTIA LVAVAGTTEF GQIDPIEEIG 190 200 210 220 230 240 RLAQEHDLYL HVDAAFGGFV IPFMDRPAKF DFEIPGVQSI TIDPHKMGLS TIPSGGLLYR 250 260 270 280 290 300 SESLMKVLEI NAQYLTSMVQ TSLAGTRSGA SAASAYAVLQ YLGRAGYREI VATCMENTRI 310 320 330 340 350 360 LREQLEDMGM EPIIEPVLNI VTARAKDPVG LRKKLAEKNW YVSTTVHPCA LRMVVMPHVT 370 ADVIEAFTAD LKKVI

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ36795.1.
RefSeq	YP_686121.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W498.
ModBase	Search...
Protein-protein interaction databases
STRING	351160.RCIX1543.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ36795; CAJ36795; RCIX1543.
GeneID	5142888.
KEGG	rci:RCIX1543.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0076.
HOGENOM	HOG000246269.
KO	K01592.
OMA	DAPYLTE.
ProtClustDB	PRK13520.
Enzyme and pathway databases
UniPathway	UPA00080.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_01610. Tyr_decarbox.
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR020931. Tyr_deCO2ase. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MFNA_UNCMA

Accession

Primary (citable) accession number: Q0W498

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program