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Q0W498

- MFNA_UNCMA

UniProt

Q0W498 - MFNA_UNCMA

Protein

L-tyrosine decarboxylase

Gene

mfnA

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine.UniRule annotation

    Catalytic activityi

    L-tyrosine = tyramine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: UniProtKB-HAMAP
    2. tyrosine decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. coenzyme biosynthetic process Source: UniProtKB-HAMAP
    2. tyrosine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciUMET351160:GJT4-1471-MONOMER.
    UniPathwayiUPA00080.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-tyrosine decarboxylaseUniRule annotation (EC:4.1.1.25UniRule annotation)
    Short name:
    TDCUniRule annotation
    Gene namesi
    Name:mfnAUniRule annotation
    Ordered Locus Names:UNCMA_14340
    ORF Names:RCIX1543
    OrganismiUncultured methanogenic archaeon RC-I
    Taxonomic identifieri351160 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
    ProteomesiUP000000663: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375L-tyrosine decarboxylasePRO_0000293191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei226 – 2261N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi351160.RCIX1543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0W498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000246269.
    KOiK01592.
    OMAiKLVWAEL.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_01610. Tyr_decarbox.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR020931. Tyr_deCO2ase.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0W498-1 [UniParc]FASTAAdd to Basket

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    MRERGLGEEE IFAELCEARS RDVPYGRVLS SMCTNPHPIA VKAHQEFVNT    50
    NLGDPKLFPG TADIEHRCIG LIGDLLHLPA ATGYISTGGT ESNIQALRTA 100
    IQMKHTDRRR ANIVVPESAH YSFEKASQML GIAIRRAPLD DLLRADPSEM 150
    AALIDKNTIA LVAVAGTTEF GQIDPIEEIG RLAQEHDLYL HVDAAFGGFV 200
    IPFMDRPAKF DFEIPGVQSI TIDPHKMGLS TIPSGGLLYR SESLMKVLEI 250
    NAQYLTSMVQ TSLAGTRSGA SAASAYAVLQ YLGRAGYREI VATCMENTRI 300
    LREQLEDMGM EPIIEPVLNI VTARAKDPVG LRKKLAEKNW YVSTTVHPCA 350
    LRMVVMPHVT ADVIEAFTAD LKKVI 375
    Length:375
    Mass (Da):41,138
    Last modified:September 5, 2006 - v1
    Checksum:iE8990460A4847961
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ36795.1.
    RefSeqiYP_686121.1. NC_009464.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ36795; CAJ36795; RCIX1543.
    GeneIDi5142888.
    KEGGirci:RCIX1543.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ36795.1 .
    RefSeqi YP_686121.1. NC_009464.1.

    3D structure databases

    ProteinModelPortali Q0W498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351160.RCIX1543.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ36795 ; CAJ36795 ; RCIX1543 .
    GeneIDi 5142888.
    KEGGi rci:RCIX1543.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000246269.
    KOi K01592.
    OMAi KLVWAEL.

    Enzyme and pathway databases

    UniPathwayi UPA00080 .
    BioCyci UMET351160:GJT4-1471-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_01610. Tyr_decarbox.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR020931. Tyr_deCO2ase.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03812. tyr_de_CO2_Arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
      Erkel C., Kube M., Reinhardt R., Liesack W.
      Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMFNA_UNCMA
    AccessioniPrimary (citable) accession number: Q0W498
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3