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Protein

L-tyrosine decarboxylase

Gene

mfnA

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: UniProtKB-HAMAP
  2. tyrosine decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme biosynthetic process Source: UniProtKB-HAMAP
  2. tyrosine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciUMET351160:GJT4-1471-MONOMER.
UniPathwayiUPA00080.

Names & Taxonomyi

Protein namesi
Recommended name:
L-tyrosine decarboxylaseUniRule annotation (EC:4.1.1.25UniRule annotation)
Short name:
TDCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:UNCMA_14340
ORF Names:RCIX1543
OrganismiUncultured methanogenic archaeon RC-I
Taxonomic identifieri351160 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
ProteomesiUP000000663 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375L-tyrosine decarboxylasePRO_0000293191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351160.RCIX1543.

Structurei

3D structure databases

ProteinModelPortaliQ0W498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000246269.
KOiK18933.
OMAiIEPVMNV.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_01610. Tyr_decarbox.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0W498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRERGLGEEE IFAELCEARS RDVPYGRVLS SMCTNPHPIA VKAHQEFVNT
60 70 80 90 100
NLGDPKLFPG TADIEHRCIG LIGDLLHLPA ATGYISTGGT ESNIQALRTA
110 120 130 140 150
IQMKHTDRRR ANIVVPESAH YSFEKASQML GIAIRRAPLD DLLRADPSEM
160 170 180 190 200
AALIDKNTIA LVAVAGTTEF GQIDPIEEIG RLAQEHDLYL HVDAAFGGFV
210 220 230 240 250
IPFMDRPAKF DFEIPGVQSI TIDPHKMGLS TIPSGGLLYR SESLMKVLEI
260 270 280 290 300
NAQYLTSMVQ TSLAGTRSGA SAASAYAVLQ YLGRAGYREI VATCMENTRI
310 320 330 340 350
LREQLEDMGM EPIIEPVLNI VTARAKDPVG LRKKLAEKNW YVSTTVHPCA
360 370
LRMVVMPHVT ADVIEAFTAD LKKVI
Length:375
Mass (Da):41,138
Last modified:September 5, 2006 - v1
Checksum:iE8990460A4847961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM114193 Genomic DNA. Translation: CAJ36795.1.
RefSeqiYP_686121.1. NC_009464.1.

Genome annotation databases

EnsemblBacteriaiCAJ36795; CAJ36795; RCIX1543.
GeneIDi5142888.
KEGGirci:RCIX1543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM114193 Genomic DNA. Translation: CAJ36795.1.
RefSeqiYP_686121.1. NC_009464.1.

3D structure databases

ProteinModelPortaliQ0W498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351160.RCIX1543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ36795; CAJ36795; RCIX1543.
GeneIDi5142888.
KEGGirci:RCIX1543.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000246269.
KOiK18933.
OMAiIEPVMNV.

Enzyme and pathway databases

UniPathwayiUPA00080.
BioCyciUMET351160:GJT4-1471-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_01610. Tyr_decarbox.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
    Erkel C., Kube M., Reinhardt R., Liesack W.
    Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMFNA_UNCMA
AccessioniPrimary (citable) accession number: Q0W498
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 5, 2006
Last modified: April 1, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.