Q0W2Q3 (SURE_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	UNCMA_09120
ORF Names:	RCIX2221

Organism

Uncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]

Taxonomic identifier

351160 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › environmental samples

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW tubulin-tyrosine ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	5'-nucleotidase surE HAMAP MF_00060		PRO_0000335300
Sites
	Metal binding	10	1	Divalent metal cation By similarity
	Metal binding	11	1	Divalent metal cation By similarity
	Metal binding	41	1	Divalent metal cation By similarity
	Metal binding	97	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0W2Q3 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 509CFEA9721072F0	FASTA	266	28,805
	10 20 30 40 50 60 MTYRILITND DGVASPGLMA VYEAVRSLGE AVIVAPASQQ SAVGRSMTLF EPLRIEKMNL 70 80 90 100 110 120 QGTMAYAVNG TPTDSVIMGM YVVMADRKPD LVISGINIGE NLSAEAVTTS GTIGAAMEAA 130 140 150 160 170 180 NQGVPAIAVS MHVLEEADKF ATAAMAQDYA VAQRLIGKLA RQVLENGLPE GVDLLNVNIP 190 200 210 220 230 240 AGATPETPVV VTRLARRMYD TIVHHRMDPR GRSYYWVDGT IVADAPEGTD LHTVHQRRQV 250 260 SITPLRLDMT ACEQTVEIER IIRDNW

References

[1]	"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere." Erkel C., Kube M., Reinhardt R., Liesack W. Science 313:370-372(2006) [PubMed: 16857943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM114193 Genomic DNA. Translation: CAJ37340.1.
RefSeq	YP_686666.1. NC_009464.1.
3D structure databases
ProteinModelPortal	Q0W2Q3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0W2Q3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5144265.
GenomeReviews	Gene locus UNCMA_09120 in contig AM114193_GR.
KEGG	rci:RCIX2221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05083.
HOGENOM	HBG600532.
OMA	NGFYYVN.
PhylomeDB	Q0W2Q3.
ProtClustDB	CLSK2789241.
Enzyme and pathway databases
BioCyc	UMET351160:RCIX2221-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. IPR004344. Tub_tyr_ligase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
PANTHER	PTHR12241. Tub_tyr_ligase. 1 hit.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_UNCMA

Accession

Primary (citable) accession number: Q0W2Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program