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Q0W1L9 (THIM_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:UNCMA_05330
ORF Names:RCIX2677
OrganismUncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]
Taxonomic identifier351160 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383923

Sites

Binding site451Substrate; via amide nitrogen By similarity
Binding site1211ATP By similarity
Binding site1671ATP By similarity
Binding site1941Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0W1L9 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 1B58E2EFAAC413B6

FASTA26627,592
        10         20         30         40         50         60 
MDARSLSGIL TEVREKRPLV HHITNYVTVN DCANVTLCIG AAPVMAHAHD EVAEMVAMAG 

        70         80         90        100        110        120 
ALVLNIGTLD HRQVESMLAA GHRANELNIP IILDPVGAGA TRLRTETAKT LLHKLHVSVL 

       130        140        150        160        170        180 
KGNAGEIATL AGAEGKVRGV DSAGVSGDPA EFARGLAEKL GLVVAVSGAT DIVTDGKRLI 

       190        200        210        220        230        240 
YVDNGHEMMG KLSGTGCMAS SISGAFAAAS KDYVTSTAAA LASFGVAGEK AAKRCEGPAS 

       250        260 
FKIALLDEIY RLTADEVAHN IKVRFA 

« Hide

References

[1]"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
Erkel C., Kube M., Reinhardt R., Liesack W.
Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM114193 Genomic DNA. Translation: CAJ37724.1.
RefSeqYP_687050.1. NC_009464.1.

3D structure databases

ProteinModelPortalQ0W1L9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351160.RCIX2677.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ37724; CAJ37724; RCIX2677.
GeneID5145312.
KEGGrci:RCIX2677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.

Enzyme and pathway databases

BioCycUMET351160:GJT4-547-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_UNCMA
AccessionPrimary (citable) accession number: Q0W1L9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways