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Protein

DNA ligase

Gene

lig

Organism
Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei249ATPUniRule annotation1
Active sitei251N6-AMP-lysine intermediateUniRule annotation1
Binding sitei256ATPUniRule annotation1
Binding sitei271ATPUniRule annotation1
Binding sitei301ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1
Binding sitei424ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMARV351160:G1GJJ-309-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:UNCMA_02940
ORF Names:RRC227
OrganismiMethanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Taxonomic identifieri351160 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
Proteomesi
  • UP000000663 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652681 – 568DNA ligaseAdd BLAST568

Proteomic databases

PRIDEiQ0W0X1

Interactioni

Protein-protein interaction databases

STRINGi351160.RRC227

Structurei

3D structure databases

ProteinModelPortaliQ0W0X1
SMRiQ0W0X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q0W0X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFKELVSLY ESLRSTSSRL EKTAMIAAFL QQAPVDELPV IVTFLTGRIF
60 70 80 90 100
PEWDQRKIGI ASQSMIKIIS TITHNPEDAV VESYKKTGHL GVTAEEMFQK
110 120 130 140 150
RRQVTFFEPE DITVKEVAET FYEIARSSGA GSSAKKQKIL IGLLHRATTP
160 170 180 190 200
KEAHYIVSLT IEYVLSGAKE GVMEDAIGQA FGATLDQVRR AHMLTSDLGE
210 220 230 240 250
TARIAKTEGA AGLEAITIRP MRPVRPMLAQ NVSSIREALD TMGGVAEFEM
260 270 280 290 300
KYDGARLQIH KVGKDVKLYS RRLEDLTDAL PEIVGYVRES VKSDTAILDS
310 320 330 340 350
ECIAIDKDTG RPIPFQNILT RLRRIHKVEE TQKQFPLILR PFDVLFNQGQ
360 370 380 390 400
STIDLPLRER RKILEEIVIA TDSVIQPARA LVTDQEEKAQ ELFEESVKSG
410 420 430 440 450
NEGLMGKDLN ATYTPGVRGK KMVKIKSVLD TLDLAIVSAE WGHGRKAGWL
460 470 480 490 500
TSFEVAALDE ETGDYVILGR VASGFSDEQL IEMTEKLKPL ITGEHGRIVD
510 520 530 540 550
VRPEIIVEVK FEEIQKSPIY SSGYALRFPR LVRVRDDLSP EEVNSFTRVM
560
NIYNVQQRYS ISENGLRK
Length:568
Mass (Da):63,701
Last modified:September 5, 2006 - v1
Checksum:iC2F4F34F06A1FB48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM114193 Genomic DNA Translation: CAJ37972.1
RefSeqiWP_012034623.1, NC_009464.1

Genome annotation databases

EnsemblBacteriaiCAJ37972; CAJ37972; RRC227
GeneIDi5143728
KEGGirci:RRC227
PATRICifig|351160.9.peg.310

Similar proteinsi

Entry informationi

Entry nameiDNLI_METAR
AccessioniPrimary (citable) accession number: Q0W0X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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