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Q0W0X1 (DNLI_UNCMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:UNCMA_02940
ORF Names:RRC227
OrganismUncultured methanogenic archaeon RC-I [Complete proteome] [HAMAP]
Taxonomic identifier351160 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568DNA ligase HAMAP-Rule MF_00407
PRO_0000365268

Sites

Active site2511N6-AMP-lysine intermediate By similarity
Binding site2491ATP By similarity
Binding site2561ATP By similarity
Binding site2711ATP By similarity
Binding site3011ATP By similarity
Binding site3421ATP By similarity
Binding site4181ATP By similarity
Binding site4241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0W0X1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: C2F4F34F06A1FB48

FASTA56863,701
        10         20         30         40         50         60 
MLFKELVSLY ESLRSTSSRL EKTAMIAAFL QQAPVDELPV IVTFLTGRIF PEWDQRKIGI 

        70         80         90        100        110        120 
ASQSMIKIIS TITHNPEDAV VESYKKTGHL GVTAEEMFQK RRQVTFFEPE DITVKEVAET 

       130        140        150        160        170        180 
FYEIARSSGA GSSAKKQKIL IGLLHRATTP KEAHYIVSLT IEYVLSGAKE GVMEDAIGQA 

       190        200        210        220        230        240 
FGATLDQVRR AHMLTSDLGE TARIAKTEGA AGLEAITIRP MRPVRPMLAQ NVSSIREALD 

       250        260        270        280        290        300 
TMGGVAEFEM KYDGARLQIH KVGKDVKLYS RRLEDLTDAL PEIVGYVRES VKSDTAILDS 

       310        320        330        340        350        360 
ECIAIDKDTG RPIPFQNILT RLRRIHKVEE TQKQFPLILR PFDVLFNQGQ STIDLPLRER 

       370        380        390        400        410        420 
RKILEEIVIA TDSVIQPARA LVTDQEEKAQ ELFEESVKSG NEGLMGKDLN ATYTPGVRGK 

       430        440        450        460        470        480 
KMVKIKSVLD TLDLAIVSAE WGHGRKAGWL TSFEVAALDE ETGDYVILGR VASGFSDEQL 

       490        500        510        520        530        540 
IEMTEKLKPL ITGEHGRIVD VRPEIIVEVK FEEIQKSPIY SSGYALRFPR LVRVRDDLSP 

       550        560 
EEVNSFTRVM NIYNVQQRYS ISENGLRK 

« Hide

References

[1]"Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
Erkel C., Kube M., Reinhardt R., Liesack W.
Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM114193 Genomic DNA. Translation: CAJ37972.1.
RefSeqYP_687298.1. NC_009464.1.

3D structure databases

ProteinModelPortalQ0W0X1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351160.RRC227.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ37972; CAJ37972; RRC227.
GeneID5143728.
KEGGrci:RRC227.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMANPVESRY.
ProtClustDBCLSK2788994.

Enzyme and pathway databases

BioCycUMET351160:GJT4-304-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_UNCMA
AccessionPrimary (citable) accession number: Q0W0X1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families