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Q0W0X1

- DNLI_UNCMA

UniProt

Q0W0X1 - DNLI_UNCMA

Protein

DNA ligase

Gene

lig

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei249 – 2491ATPUniRule annotation
    Active sitei251 – 2511N6-AMP-lysine intermediateUniRule annotation
    Binding sitei256 – 2561ATPUniRule annotation
    Binding sitei271 – 2711ATPUniRule annotation
    Binding sitei301 – 3011ATPUniRule annotation
    Binding sitei342 – 3421ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation
    Binding sitei424 – 4241ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA recombination Source: UniProtKB-HAMAP
    4. DNA repair Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciUMET351160:GJT4-304-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:UNCMA_02940
    ORF Names:RRC227
    OrganismiUncultured methanogenic archaeon RC-I
    Taxonomic identifieri351160 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
    ProteomesiUP000000663: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568DNA ligasePRO_0000365268Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351160.RRC227.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0W0X1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiVPIVIPY.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0W0X1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFKELVSLY ESLRSTSSRL EKTAMIAAFL QQAPVDELPV IVTFLTGRIF    50
    PEWDQRKIGI ASQSMIKIIS TITHNPEDAV VESYKKTGHL GVTAEEMFQK 100
    RRQVTFFEPE DITVKEVAET FYEIARSSGA GSSAKKQKIL IGLLHRATTP 150
    KEAHYIVSLT IEYVLSGAKE GVMEDAIGQA FGATLDQVRR AHMLTSDLGE 200
    TARIAKTEGA AGLEAITIRP MRPVRPMLAQ NVSSIREALD TMGGVAEFEM 250
    KYDGARLQIH KVGKDVKLYS RRLEDLTDAL PEIVGYVRES VKSDTAILDS 300
    ECIAIDKDTG RPIPFQNILT RLRRIHKVEE TQKQFPLILR PFDVLFNQGQ 350
    STIDLPLRER RKILEEIVIA TDSVIQPARA LVTDQEEKAQ ELFEESVKSG 400
    NEGLMGKDLN ATYTPGVRGK KMVKIKSVLD TLDLAIVSAE WGHGRKAGWL 450
    TSFEVAALDE ETGDYVILGR VASGFSDEQL IEMTEKLKPL ITGEHGRIVD 500
    VRPEIIVEVK FEEIQKSPIY SSGYALRFPR LVRVRDDLSP EEVNSFTRVM 550
    NIYNVQQRYS ISENGLRK 568
    Length:568
    Mass (Da):63,701
    Last modified:September 5, 2006 - v1
    Checksum:iC2F4F34F06A1FB48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ37972.1.
    RefSeqiYP_687298.1. NC_009464.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ37972; CAJ37972; RRC227.
    GeneIDi5143728.
    KEGGirci:RRC227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ37972.1 .
    RefSeqi YP_687298.1. NC_009464.1.

    3D structure databases

    ProteinModelPortali Q0W0X1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351160.RRC227.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ37972 ; CAJ37972 ; RRC227 .
    GeneIDi 5143728.
    KEGGi rci:RRC227.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi VPIVIPY.

    Enzyme and pathway databases

    BioCyci UMET351160:GJT4-304-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
      Erkel C., Kube M., Reinhardt R., Liesack W.
      Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDNLI_UNCMA
    AccessioniPrimary (citable) accession number: Q0W0X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3