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Q0W0J3

- HIS4_UNCMA

UniProt

Q0W0J3 - HIS4_UNCMA

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Uncultured methanogenic archaeon RC-I
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101Proton acceptorUniRule annotation
    Active sitei132 – 1321Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciUMET351160:GJT4-171-MONOMER.
    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:hisAUniRule annotation
    Ordered Locus Names:UNCMA_01660
    ORF Names:RRC389
    OrganismiUncultured methanogenic archaeon RC-I
    Taxonomic identifieri351160 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
    ProteomesiUP000000663: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2402401-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000290579Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351160.RRC389.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0W0J3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    OMAiQRDYGSD.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0W0J3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFNVIPAID LKGGKCVQLV QGVPGTEMVS IDDAVEVAAG WVGQGAKTLH    50
    IIDLDGAFSG SRKNAYIMED IVSKFDVDVQ VGGGIRDYET AKYLLSLGID 100
    RVILGTAAIK NPDLVRQLAD EFGSETVMVS LDSKQGEVVI EGWTESSGKT 150
    TNEMGKFFSE IGAGSILYTN VDVEGLLKGV NEDPVRSLVN SVTIPVIASG 200
    GVAKIDDLVK IKNTGAAGVV VGSALYKGLF TLREAIDKVS 240
    Length:240
    Mass (Da):25,255
    Last modified:September 5, 2006 - v1
    Checksum:i8FF98D4D0F1649B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ38100.1.
    RefSeqiYP_687426.1. NC_009464.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ38100; CAJ38100; RRC389.
    GeneIDi5144440.
    KEGGirci:RRC389.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM114193 Genomic DNA. Translation: CAJ38100.1 .
    RefSeqi YP_687426.1. NC_009464.1.

    3D structure databases

    ProteinModelPortali Q0W0J3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351160.RRC389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ38100 ; CAJ38100 ; RRC389 .
    GeneIDi 5144440.
    KEGGi rci:RRC389.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    OMAi QRDYGSD.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    BioCyci UMET351160:GJT4-171-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of rice cluster I archaea -- the key methane producers in the rice rhizosphere."
      Erkel C., Kube M., Reinhardt R., Liesack W.
      Science 313:370-372(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiHIS4_UNCMA
    AccessioniPrimary (citable) accession number: Q0W0J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3