ID   PYRB_ALCBS              Reviewed;         337 AA.
AC   Q0VTM5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=ABO_0035;
OS   Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Alcanivoracaceae; Alcanivorax.
OX   NCBI_TaxID=393595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16878126; DOI=10.1038/nbt1232;
RA   Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T.,
RA   Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M.,
RA   Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N.,
RA   Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T., Puehler A.,
RA   Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M.,
RA   Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N.;
RT   "Genome sequence of the ubiquitous hydrocarbon-degrading marine
RT   bacterium Alcanivorax borkumensis.";
RL   Nat. Biotechnol. 24:997-1004(2006).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; AM286690; CAL15483.1; -; Genomic_DNA.
DR   RefSeq; YP_691755.1; -.
DR   GeneID; 4211154; -.
DR   GenomeReviews; AM286690_GR; ABO_0035.
DR   KEGG; abo:ABO_0035; -.
DR   NMPDR; fig|393595.12.peg.34; -.
DR   HOGENOM; Q0VTM5; -.
DR   OMA; Q0VTM5; YFAGPEE.
DR   BioCyc; ABOR393595:ABO_0035-MON; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    337       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000321065.
SQ   SEQUENCE   337 AA;  36423 MW;  DCC0DC0B2C9D3311 CRC64;
     MTPTLAPSSR VQLTDSGKLR HFLTTEHLPR SLLEDILDTA ASFVDVGGRA IKKVPLLRGK
     TVVNLFFESS TRTRSTFELA AQRLSADVLN LDIAKSATSK GETLLDTLRN LEAMAADMFV
     VRHQDSGAPF FIANEVTPNV AVINAGDGRH AHPTQAMLDM YTIRHYKGGF EGLKVAIVGD
     ILHSRVARSQ VHALNILGAD EVRLIGPKTL LPVDAEALGA TVFTDMAQGL KDVDVVIMLR
     LQKERMDSAL LPSEAEFFRL YGLNNDKLLF AKEDAIVMHP GPINRGVEIA SEVADGPRSV
     ILNQVTFGIA VRMAVMSMAI SGQDSDMSAA GGAHGQR
//