ID   AROE_ALCBS              Reviewed;         278 AA.
AC   Q0VTD6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=ABO_0136;
OS   Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Alcanivoracaceae; Alcanivorax.
OX   NCBI_TaxID=393595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16878126; DOI=10.1038/nbt1232;
RA   Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T.,
RA   Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M.,
RA   Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N.,
RA   Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T., Puehler A.,
RA   Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M.,
RA   Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N.;
RT   "Genome sequence of the ubiquitous hydrocarbon-degrading marine
RT   bacterium Alcanivorax borkumensis.";
RL   Nat. Biotechnol. 24:997-1004(2006).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AM286690; CAL15584.1; -; Genomic_DNA.
DR   RefSeq; YP_691856.1; -.
DR   GeneID; 4213487; -.
DR   GenomeReviews; AM286690_GR; ABO_0136.
DR   KEGG; abo:ABO_0136; -.
DR   NMPDR; fig|393595.12.peg.135; -.
DR   HOGENOM; Q0VTD6; -.
DR   OMA; Q0VTD6; YDMMYGR.
DR   BioCyc; ABOR393595:ABO_0136-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    278       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325096.
FT   NP_BIND     135    139       NADP (By similarity).
FT   ACT_SITE     74     74       Proton acceptor (Potential).
SQ   SEQUENCE   278 AA;  29554 MW;  F195E70CD6516CAB CRC64;
     MSGEKDRADT GLYCVFGNPV SHSRSPEIHH AFAAQHSDPV QYEKREAPLD DFAGAVQAFR
     EAGGLGANVT VPFKEQAFAL CDAITERADQ AGAVNTLWWD GDQLHGDNTD GAGLVKDIRN
     NQGWTIRKKR VLILGAGGAV RGVLGPILAQ EPTLLRIANR TKEKAEALAG NVMKGEGPPV
     LGGGLDNLMG QFDLVINAIS AGLHGEMPAL PDGLLAEGAV AYDMVYGSEP TPFMRWAEQQ
     GAAATADGLG MLVEQAAEAF EIWRGWRPNT APVMASLR
//