Reviewed, UniProtKB/Swiss-Prot Q0VTD6 (AROE_ALCBS)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	ABO_0136

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325096
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity
Sites
	Active site	74	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0VTD6-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: F195E70CD6516CAB	FASTA	278	29,554
	10 20 30 40 50 60 MSGEKDRADT GLYCVFGNPV SHSRSPEIHH AFAAQHSDPV QYEKREAPLD DFAGAVQAFR 70 80 90 100 110 120 EAGGLGANVT VPFKEQAFAL CDAITERADQ AGAVNTLWWD GDQLHGDNTD GAGLVKDIRN 130 140 150 160 170 180 NQGWTIRKKR VLILGAGGAV RGVLGPILAQ EPTLLRIANR TKEKAEALAG NVMKGEGPPV 190 200 210 220 230 240 LGGGLDNLMG QFDLVINAIS AGLHGEMPAL PDGLLAEGAV AYDMVYGSEP TPFMRWAEQQ 250 260 270 GAAATADGLG MLVEQAAEAF EIWRGWRPNT APVMASLR

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM286690 Genomic DNA. Translation: CAL15584.1.
RefSeq	YP_691856.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4213487.
GenomeReviews	Gene locus ABO_0136 in contig AM286690_GR.
KEGG	abo:ABO_0136.
NMPDR	fig|393595.12.peg.135.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0VTD6.
OMA	Q0VTD6. YDMMYGR.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_0136-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_ALCBS

Accession

Primary (citable) accession number: Q0VTD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)