ID   HEMH_ALCBS              Reviewed;         341 AA.
AC   Q0VSV6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Ferrochelatase;
DE            EC=4.99.1.1;
DE   AltName: Full=Protoheme ferro-lyase;
DE   AltName: Full=Heme synthetase;
GN   Name=hemH; OrderedLocusNames=ABO_0294;
OS   Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Alcanivoracaceae; Alcanivorax.
OX   NCBI_TaxID=393595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16878126; DOI=10.1038/nbt1232;
RA   Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T.,
RA   Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M.,
RA   Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N.,
RA   Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T., Puehler A.,
RA   Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M.,
RA   Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N.;
RT   "Genome sequence of the ubiquitous hydrocarbon-degrading marine
RT   bacterium Alcanivorax borkumensis.";
RL   Nat. Biotechnol. 24:997-1004(2006).
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX.
CC   -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
CC   -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme
CC       from protoporphyrin-IX: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
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DR   EMBL; AM286690; CAL15742.1; -; Genomic_DNA.
DR   RefSeq; YP_692014.1; -.
DR   GeneID; 4212187; -.
DR   GenomeReviews; AM286690_GR; ABO_0294.
DR   KEGG; abo:ABO_0294; -.
DR   NMPDR; fig|393595.12.peg.292; -.
DR   HOGENOM; Q0VSV6; -.
DR   OMA; Q0VSV6; MSFHGLP.
DR   BioCyc; ABOR393595:ABO_0294-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00323; -; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   PANTHER; PTHR11108; Ferrochelatase; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   ProDom; PD002792; Ferrochelatase; 1.
DR   TIGRFAMs; TIGR00109; hemH; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Heme biosynthesis; Iron; Lyase;
KW   Metal-binding; Porphyrin biosynthesis.
FT   CHAIN         1    341       Ferrochelatase.
FT                                /FTId=PRO_1000019271.
FT   METAL       210    210       Iron (By similarity).
FT   METAL       291    291       Iron (By similarity).
SQ   SEQUENCE   341 AA;  38529 MW;  2C5B379B9284C704 CRC64;
     MAYKGQENLE HLNPRKVGVL ITNLGTPDAP ETGALRRYLR EFLSDPRVVE IPRFIWFFIL
     NLVILVIRPR KSAEAYKSVW TEEGSPLLVY SLAQGEGIRQ RLQSKYGDDV VVRVAMRYGN
     PSIASQLQAF EDEGIRKLVV LPLYPQYSGS TNGSTFDAVA QDFMGRRLLP DLRFISHYPD
     YPPYIQAMAE HIRAYREKNG SADKLVFSFH GVPKRFLLKG DPYFHECHQT SQLLAKALGL
     SDGQWMTTFQ SRFGAEEWLQ PYTDATMKSL PGEGVKSVQV FCPGFSADCL ETVEEIDQEN
     REYFEEAGGE SFAYISALNA EPAHLDALAQ LVEDNLQGFL P
//