Reviewed, UniProtKB/Swiss-Prot Q0VSV6 (HEMH_ALCBS)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	ABO_0294

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Ferrochelatase HAMAP MF_00323		PRO_1000019271
Sites
	Metal binding	210	1	Iron By similarity
	Metal binding	291	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0VSV6-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 2C5B379B9284C704	FASTA	341	38,529
	10 20 30 40 50 60 MAYKGQENLE HLNPRKVGVL ITNLGTPDAP ETGALRRYLR EFLSDPRVVE IPRFIWFFIL 70 80 90 100 110 120 NLVILVIRPR KSAEAYKSVW TEEGSPLLVY SLAQGEGIRQ RLQSKYGDDV VVRVAMRYGN 130 140 150 160 170 180 PSIASQLQAF EDEGIRKLVV LPLYPQYSGS TNGSTFDAVA QDFMGRRLLP DLRFISHYPD 190 200 210 220 230 240 YPPYIQAMAE HIRAYREKNG SADKLVFSFH GVPKRFLLKG DPYFHECHQT SQLLAKALGL 250 260 270 280 290 300 SDGQWMTTFQ SRFGAEEWLQ PYTDATMKSL PGEGVKSVQV FCPGFSADCL ETVEEIDQEN 310 320 330 340 REYFEEAGGE SFAYISALNA EPAHLDALAQ LVEDNLQGFL P

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286690 Genomic DNA. Translation: CAL15742.1.
RefSeq	YP_692014.1.
3D structure databases
SMR	Q0VSV6. Positions 15-338.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VSV6.
Genome annotation databases
GeneID	4212187.
GenomeReviews	Gene locus ABO_0294 in contig AM286690_GR.
KEGG	abo:ABO_0294.
NMPDR	fig|393595.12.peg.292.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0276.
HOGENOM	HBG697135.
OMA	IRPAKSA.
PhylomeDB	Q0VSV6.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_0294-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_ALCBS

Accession

Primary (citable) accession number: Q0VSV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)