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Q0VSR7

- PNP_ALCBS

UniProt

Q0VSR7 - PNP_ALCBS

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciABOR393595:GHRI-335-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:ABO_0333
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Polyribonucleotide nucleotidyltransferasePRO_0000329489Add
BLAST

Interactioni

Subunit structurei

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.UniRule annotation

Protein-protein interaction databases

STRINGi393595.ABO_0333.

Structurei

3D structure databases

ProteinModelPortaliQ0VSR7.
SMRiQ0VSR7. Positions 619-694.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69269S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VSR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNKITKQIQ FGRDTVTLET GQIARQATAA VMVRIGDTQV LVTVVGRKEA
60 70 80 90 100
NPGQNFFPLT VNYQEKTYAT GRIPGGFLKR EGRPSEKETL TCRLIDRPIR
110 120 130 140 150
PLFPKGFMNE VQVVATVMSS DKNRDPDIAA LIGTSAALSI SGIPFSGPIG
160 170 180 190 200
AARVGYKDGM YILNPSYSEL AESALDLVVA GTEPAVLMVE SEAQELSEDQ
210 220 230 240 250
MLGAVLFGHM EMQPLIQGIK EFAAEVGTET WDWKPAEQNE TLKAAIKDKF
260 270 280 290 300
AAALGEAYTI TEKMARYAKV GELRDACVAE FATGEDGAPE ADEVKDLFGK
310 320 330 340 350
IEKSVVREAV VSGKPRIDGR ALDAVRAIDC QVGTLAKTHG SALFTRGETQ
360 370 380 390 400
AIVTATLGGM RDAQFIDALE GSHQDHFMLQ YNFPPYCVGE TGFIGSPKRR
410 420 430 440 450
EIGHGRLARR GVEAVVPSVQ DFPYTIRVVS EITESNGSSS MASVCGTSMA
460 470 480 490 500
LMDAGVPLTA PVAGIAMGLV KEEDGRYAVL SDILGDEDHL GDMDFKVAGT
510 520 530 540 550
ARGVTALQMD IKIEGITEEI MEKALNQANA GRLHILGEMN KAIAESRSEV
560 570 580 590 600
SDNAPTLLTL KINPDKIRDV IGKGGATIRA LTEETGCTID IEDDGSVKIY
610 620 630 640 650
GETREKADEA VRRVEEITAE AEVGAIYEGK VTRVVDFGAF VAIMPGTEGL
660 670 680 690
LHISQIAEER VEKVTDYVNE GEIIKVKVLD VDQRGRIKLS MKEAKED
Length:697
Mass (Da):75,304
Last modified:September 5, 2006 - v1
Checksum:i29A4A86B27D2FD6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL15781.1.
RefSeqiWP_011587628.1. NC_008260.1.
YP_692053.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL15781; CAL15781; ABO_0333.
GeneIDi4212265.
KEGGiabo:ABO_0333.
PATRICi20838275. VBIAlcBor124741_0353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL15781.1 .
RefSeqi WP_011587628.1. NC_008260.1.
YP_692053.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VSR7.
SMRi Q0VSR7. Positions 619-694.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393595.ABO_0333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL15781 ; CAL15781 ; ABO_0333 .
GeneIDi 4212265.
KEGGi abo:ABO_0333.
PATRICi 20838275. VBIAlcBor124741_0353.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ABOR393595:GHRI-335-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiPNP_ALCBS
AccessioniPrimary (citable) accession number: Q0VSR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3