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Q0VSP6

- GSA_ALCBS

UniProt

Q0VSP6 - GSA_ALCBS

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, ABO_0354
Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciABOR393595:GHRI-356-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:ABO_0354
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_0000382246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ0VSP6.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi393595.ABO_0354.

Structurei

3D structure databases

ProteinModelPortaliQ0VSP6.
SMRiQ0VSP6. Positions 1-422.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiHGHANAF.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VSP6-1 [UniParc]FASTAAdd to Basket

« Hide

MPRKHSEQLF RQAQKHIPGG VNSPVRAFKS VGGTPVFFHS ARGAHLFDED    50
DNKYIDYVGS WGPMILGHNH PHVVAAVQAA VEQGLSFGAP TATEVAMADK 100
VCELVPSMDM VRMVNSGTEA TMSAIRLARG YTGRNKIIKF EGCYHGHVDS 150
LLVKAGSGAI AIPGSPGVPE AVTADTLVLD YNDAASVTQA FKEHGDDIAA 200
VIVEPVAGNM NCVPATENFL QTLRQQCDDN GAVLIFDEVM SGFRVALGGA 250
QGHYGITPDM TTLGKIVGGG MPVGAFGGKQ AIMEHLAPLG PVYQAGTLSG 300
NPVAMAAGLA TLNLISEPGF HQALAEKTTR LLEGLTAAAH AEGVAFTTAQ 350
AGAMFGLFFT DQNRISSFTE VMACDSERFN RFFHAMLDQG IYLAPSAFEA 400
GFVSAAHSND DIDATITAAR KAFGKI 426
Length:426
Mass (Da):44,870
Last modified:September 5, 2006 - v1
Checksum:i7748B8D4B9908256
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL15802.1.
RefSeqiWP_011587649.1. NC_008260.1.
YP_692074.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL15802; CAL15802; ABO_0354.
GeneIDi4212189.
KEGGiabo:ABO_0354.
PATRICi20838319. VBIAlcBor124741_0375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL15802.1 .
RefSeqi WP_011587649.1. NC_008260.1.
YP_692074.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VSP6.
SMRi Q0VSP6. Positions 1-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393595.ABO_0354.

Proteomic databases

PRIDEi Q0VSP6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL15802 ; CAL15802 ; ABO_0354 .
GeneIDi 4212189.
KEGGi abo:ABO_0354.
PATRICi 20838319. VBIAlcBor124741_0375.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi HGHANAF.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci ABOR393595:GHRI-356-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiGSA_ALCBS
AccessioniPrimary (citable) accession number: Q0VSP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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