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Q0VSD8 (ISPH_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
EC=1.17.1.2
Gene names
Name:ispH
Ordered Locus Names:ABO_0462
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3113114-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
PRO_1000021082

Sequences

Sequence LengthMass (Da)Tools
Q0VSD8 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: C9CC1D812432626F

FASTA31134,259
        10         20         30         40         50         60 
MQIRLANPRG FCAGVDRAID IVNRALEVFG PPIHVRHEVV HNRYVVEDLR QRGAVFVEEL 

        70         80         90        100        110        120 
HEVPDDAIVI FSAHGVSKAV QEEAKRRQLQ VFDATCPLVT KVHMEVIRYA REGRESILIG 

       130        140        150        160        170        180 
HAGHPEVEGT MGQYDKSYGG DIYLVEDEAD VVALTVRDES KLAFVTQTTL SVDDTARVID 

       190        200        210        220        230        240 
ALRQRFPAII GPKREDICYA TTNRQDAVRQ LALECGLVLV VGSVNSSNSN RLRELAERCG 

       250        260        270        280        290        300 
AEAYLIDEPS QIEASWLKGK AAVGVTAGAS APEDLVQQVI ATLKNLGGED AEEIPGREEN 

       310 
IRFSMPKALR P

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286690 Genomic DNA. Translation: CAL15910.1.
RefSeqYP_692182.1. NC_008260.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VSD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4211493.
GenomeReviewsGene locus ABO_0462 in contig AM286690_GR.
KEGGabo:ABO_0462.
NMPDRfig|393595.12.peg.461.
PATRIC20838557. VBIAlcBor124741_0484.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAVQEMQLL.
PhylomeDBQ0VSD8.

Enzyme and pathway databases

BioCycABOR393595:ABO_0462-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPH_ALCBS
AccessionPrimary (citable) accession number: Q0VSD8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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